Abstract：
:Nonalcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of pathological hepatic conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which may predispose to liver cirrhosis and hepatocellular carcinoma (HCC). Due to the epidemic obesity, NAFLD is representing a global health issue and the leading cause of liver damage worldwide. The pathogenesis of NAFLD is closely related to insulin resistance (IR), adiposity and physical inactivity as well as genetic and epigenetic factors corroborate to the development and progression of hepatic steatosis and liver injury. Emerging evidence has outlined the implication of gut microbiota and gut-derived endotoxins as actively contributors to NAFLD pathophysiology probably due to the tight anatomo-functional crosstalk between the gut and the liver. Obesity, nutrition and environmental factors might alter intestinal permeability producing a favorable micro-environment for bacterial overgrowth, mucosal inflammation and translocation of both invasive pathogens and harmful byproducts, which, in turn, influence hepatic fat composition and exacerbated pro-inflammatory and fibrotic processes. To date, no therapeutic interventions are available for NAFLD prevention and management, except for modifications in lifestyle, diet and physical exercise even though they show discouraging results due to the poor compliance of patients. The premise of this review is to discuss the role of gut-liver axis in NAFLD and emphasize the beneficial effects of probiotics on gut microbiota composition as a novel attractive therapeutic strategy to introduce in clinical practice.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Meroni M,Longo M,Dongiovanni Pdoi
10.3390/nu11112642subject
Has Abstractpub_date
2019-11-04 00:00:00issue
11issn
2072-6643pii
nu11112642journal_volume
11pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract：INTRODUCTION:Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent a dietary approach that is likely to improve health markers. The aim of this stud...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123770
更新日期：2020-12-08 00:00:00
abstract：:Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092862
更新日期：2020-09-18 00:00:00
abstract：:Dietary n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with reduction of inflammation, although the mechanisms are poorly understood, especially how the spleen, as a secondary lymphoid organ, is involved. To investigate the effects of EPA and DHA on spleen gene expression, ma...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010050
更新日期：2017-01-10 00:00:00
abstract：:Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. OBJECTIVE:To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). DESIGN:Gut microbiot...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020278
更新日期：2020-01-21 00:00:00
abstract：:Vitamin C (ascorbate, ASC) is a critical antioxidant in the body with specific roles in the brain. Despite a recent interest in vitamin C therapies for critical care medicine, little is known about vitamin C regulation during acute inflammation and critical illnesses such as sepsis. Using a cecal slurry (CS) model of ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040911
更新日期：2020-03-26 00:00:00
abstract：:Cow's milk proteins cause allergic symptoms in 2% to 3% of all infants. In these individuals, the physiological mechanism of tolerance is broken with subsequent possible sensitization to antigens, which can lead eventually to allergic responses. The present review aims to provide an overview of different aspects of im...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11061399
更新日期：2019-06-21 00:00:00
abstract：:Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid co...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10081079
更新日期：2018-08-13 00:00:00
abstract：:Recent advances have indicated that osteocalcin, and in particular its undercarboxylated form (ucOC), is not only a nutritional biomarker reflective of vitamin K status and an indicator of bone health but also an active hormone that mediates glucose metabolism in experimental studies. This work has been supported by t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10070847
更新日期：2018-06-29 00:00:00
abstract：:Isomaltulose, a naturally-occurring isomer of sucrose, is commonly used as an alternative sweetener in foods and beverages. The goal of this study was to determine the effect of isomaltulose together with green tea on postprandial plasma glucose and insulin concentration, as well as antioxidant capacity in healthy sub...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9050464
更新日期：2017-05-06 00:00:00
abstract：:Dietary habits in adolescence persist into adulthood; thus, it is important to identify the factors that influence adolescent diet and establish a healthy diet. This study aimed to examine the association between mothers' nutrition knowledge and their children's nutrient intake inadequacy among Japanese junior high sc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092801
更新日期：2020-09-13 00:00:00
abstract：:Policies to require warnings on the front of food and drinks high in nutrients of concern (e.g., added sugar, sodium, or saturated fat) are becoming increasingly common as an obesity prevention strategy. Colombia, a country with growing prevalence of obesity, is considering implementing a similar policy. The objective...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103124
更新日期：2020-10-13 00:00:00
abstract：:Gene-environment (G × E) interactions involving job stress and mental health on risk factors of cardiovascular disease (CVD) are minimally explored. This study examined the association and G × E interaction effects of vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377, rs2071559) on ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051140
更新日期：2019-05-22 00:00:00
abstract：BACKGROUND:Oropharyngeal dysphagia (OD) and malnutrition are highly prevalent in older patients that are discharged from general hospitals (47% and 30%, respectively). AIMS:To develop a nutritional plan for these patients involving a triple adaptation of their traditional diet: (a) rheological adaptation (texture and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020425
更新日期：2019-02-18 00:00:00
abstract：:Globally, zinc deficiency is widespread, despite decades of research highlighting its negative effects on health, and in particular upon child health in low-income countries. Apart from inadequate dietary intake of bioavailable zinc, other significant contributors to zinc deficiency include the excessive intestinal lo...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7010572
更新日期：2015-01-14 00:00:00
abstract：:Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in a lipopolysaccharide (LPS)-challenge in 1-month male rats by in vivo circulating cytokine profile...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092699
更新日期：2020-09-04 00:00:00
abstract：:The phase angle (PhA) seems to be a reliable screening tool for the identification of malnutrition risk in hospitalized children with inflammatory bowel disease (IBD). The aim of the present study was to assess the body composition and nutritional status of hospitalized children and adolescents with IBD by using bioel...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040499
更新日期：2018-04-17 00:00:00
abstract：:Keratoconjunctivitis sicca (KCS) or dry eye is a disease characterized by ocular surface symptoms. This study aimed to investigate the effectiveness of oral choline alfoscerate (CA) administration as a treatment for KCS. The medical records of dry eye patients who were refractory to topical eyedrops and then took oral...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051526
更新日期：2020-05-23 00:00:00
abstract：:Patients with Parkinson's disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061551
更新日期：2020-05-26 00:00:00
abstract：:Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111607
更新日期：2018-11-01 00:00:00
abstract：:The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly t...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061275
更新日期：2019-06-05 00:00:00
abstract：:Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of the survival motor neuron protein (SMN) re...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123842
更新日期：2020-12-16 00:00:00
abstract：:Our aim is evaluating the changes in weight and dietary habits in a sample of outpatients with obesity after 1 month of enforced lockdown during the COVID-19 pandemic in Northern Italy. In this observational retrospective study, the patients of our Obesity Unit were invited to answer to a 12-question multiple-choice q...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072016
更新日期：2020-07-07 00:00:00
abstract：:Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on ex...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11123067
更新日期：2019-12-16 00:00:00
abstract：:Small bowel enteral nutrition (SBEN) may improve nutrient delivery to critically ill patients intolerant of gastric enteral nutrition. However, the optimal time and target for evaluating SBEN efficacy are unknown. This retrospective cohort study investigates these parameters in 55 critically ill patients at high nutri...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030645
更新日期：2019-03-16 00:00:00
abstract：:Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods-including fruits, vegetables, tea, wine, as well as other dietary supplements-and is responsible for various health benefits. Numerous pharmacological effects of que...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8090529
更新日期：2016-08-29 00:00:00
abstract：:The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051000
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Oral supplementation of anserine/carnosine helps preserve cognitive functions in healthy older adults. Mild cognitive impairment (MCI) is a transition between cognitive-normal and dementia. Therefore, it needs to investigate whether anserine/carnosine supplementation (ACS) has effects on subjects with MCI. ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11071626
更新日期：2019-07-17 00:00:00
abstract：DESIGN:Functional foods may be useful for people with diabetes. The soluble fibers beta glucans can modify starch digestion and improve postprandial glucose response. We analyzed the metabolic effects of a specifically designed 'functional' bread, low in starch, rich in fibers (7 g/100 g), with a beta glucan/starch rat...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9030297
更新日期：2017-03-17 00:00:00
abstract：:Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus Lactobacillus. This work presents the compiled and analysed results from the most up-to-date information from clinical trial...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030757
更新日期：2020-03-13 00:00:00
abstract：BACKGROUND:Observationally, sugar-sweetened beverage (SSB) consumption is associated with adiposity in Western children but could be confounded. We examined the association of SSB frequency with adiposity in the non-Western setting of Hong Kong. METHODS:We examined the associations of SSB consumption frequency at 11 a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041015
更新日期：2020-04-07 00:00:00
