Abstract:
:Dietary n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with reduction of inflammation, although the mechanisms are poorly understood, especially how the spleen, as a secondary lymphoid organ, is involved. To investigate the effects of EPA and DHA on spleen gene expression, male C57BL/6J mice were fed high fat diets (HFD) differing in fatty acid composition, either based on corn oil (HFD-CO), or CO enriched with 2 g/100 g EPA and DHA (HFD-ED), for eight weeks. Spleen tissue was analyzed using transcriptomics and for fatty acids profiling. Biological processes (BPs) related to the immune response, including T-cell receptor signaling pathway, T-cell differentiation and co-stimulation, myeloid dendritic cell differentiation, antigen presentation and processing, and the toll like receptor pathway were downregulated by HFD-ED compared with control and HFD-CO. These findings were supported by the down-regulation of NF-κB in HFD-ED compared with HFD-CO fed mice. Lower phospholipid arachidonic acid levels in HFD-ED compared with HFD-CO, and control mice suggest attenuation of pathways via prostaglandins and leukotrienes. The HFD-ED also upregulated BPs related to erythropoiesis and hematopoiesis compared with control and HFD-CO fed mice. Our findings suggest that EPA and DHA down-regulate the splenic immune response induced by HFD-CO, supporting earlier work that the spleen is a target organ for the anti-inflammatory effects of these n-3 fatty acids.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Soni NK,Ross AB,Scheers N,Savolainen OI,Nookaew I,Gabrielsson BG,Sandberg ASdoi
10.3390/nu9010050subject
Has Abstractpub_date
2017-01-10 00:00:00issue
1issn
2072-6643pii
nu9010050journal_volume
9pub_type
杂志文章相关文献
Nutrients文献大全abstract::In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients receive...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123873
更新日期:2020-12-18 00:00:00
abstract::A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 38...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11030561
更新日期:2019-03-06 00:00:00
abstract::Iodine excess may impair thyroid function and trigger adverse health consequences for children. This study aims to describe iodine status among breastfed infants with high iodine exposure in the Saharawi refugee camps Algeria, and further assess thyroid function and iodine status among the children three years later. ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8070398
更新日期:2016-06-28 00:00:00
abstract::Vitamin C supplementation has been shown to decrease triple-negative breast cancer (TNBC) metastasis. However, the molecular mechanism whereby vitamin C inhibits metastasis remains elusive. It has been postulated that vitamin C reduces the levels of HIF-1α, the master regulator of metastasis, by promoting its hydroxyl...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122997
更新日期:2019-12-06 00:00:00
abstract::Obesity is associated with food and eating addiction (FA), but the biobehavioral markers of this condition are poorly understood. To characterize FA, we recruited 18 healthy controls and overweight/obese adults with (n = 31) and without (n = 17) FA (H-C, FAOB, NFAOB, respectively) to assess alpha brain asymmetry at re...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113563
更新日期:2020-11-20 00:00:00
abstract::One-anastomosis gastric bypass is a promising type of bariatric surgery, but it may lead to a deficiency in important nutrients, such as fatty acids. The short-term effects of one-anastomosis gastric bypass on serum fatty acids have not been studied thus far. Therefore, the aim of this study was to determine the effec...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010187
更新日期:2020-01-09 00:00:00
abstract::The sense of food insecurity in a group of elderly people may be determined by the perception of distance to food outlets. The aim of the study was to assess the relationship between the perception of food insecurity by the elderly and their perception of the distance between the places of residence and food purchase....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12103191
更新日期:2020-10-19 00:00:00
abstract::Altered amino acid levels have been found in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). However, it is not clear whether this alteration is due to altered hepatic metabolism or insulin resistance. The aim of this study was to clarify the association among amino acid levels, fatty...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051450
更新日期:2020-05-17 00:00:00
abstract::Childhood obesity is an ongoing public health program. As such, a major public health research objective is to identify potential targets for intervention; one such area is school lunches (SL). The National School Lunch Program (NSLP) serves over 31 million children each day; the National Health and Nutrition Examinat...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9090924
更新日期:2017-08-24 00:00:00
abstract::Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementa...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7125498
更新日期:2015-11-26 00:00:00
abstract::Nephrolithiasis is a common medical condition influenced by multiple environmental factors, including diet. Since nutritional habits play a relevant role in the genesis and recurrence of kidney stones disease, dietary manipulation has become a fundamental tool for the medical management of nephrolithiasis. Dietary adv...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030779
更新日期:2020-03-15 00:00:00
abstract::Human milk is the ideal nutrition source for healthy infants during the first six months of life and a detailed characterisation of the composition of milk from mothers that deliver prematurely (<37 weeks gestation), and of how human milk changes during lactation, would benefit our understanding of the nutritional req...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8050304
更新日期:2016-05-19 00:00:00
abstract::This study sought to describe and compare adherence to the Mediterranean diet and consumption of local foods from the Huelva region among Spanish university women in relation to menstrual pain and other menstrual characteristics. This cross-sectional study included 311 health science students. The study variables were...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061759
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is hig...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12061743
更新日期:2020-06-10 00:00:00
abstract::Postprandial plasma glucose and triglyceride concentrations are predictive of relative cardiovascular disease (CVD) risk, and the pathogenesis of both insulin resistance and atherosclerosis has been attributed to acute states of hyperglycemia and hypertriglyceridemia. Postprandial lipemia and hyperglycemia suppress va...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123806
更新日期:2020-12-11 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relation...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051219
更新日期:2020-04-26 00:00:00
abstract::Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal b...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111746
更新日期:2018-11-13 00:00:00
abstract::The recruitment and infiltration of classical monocytes into damaged muscle is critical for optimal tissue remodeling. This study examined the effects of an amino acid supplement on classical monocyte recruitment following an acute bout of lower body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 years; 9...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu8070409
更新日期:2016-07-02 00:00:00
abstract::The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. Several studies have addressed lactic fermentation plus addition of e...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7042134
更新日期:2015-03-25 00:00:00
abstract::Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8080497
更新日期:2016-08-13 00:00:00
abstract:UNLABELLED:Hormonal contraceptives may produce side effects that deter women from their use as a method of family planning. In nutritionally vulnerable populations these effects may be more pronounced due to micronutrient deficiencies and health status. Previous studies have been unable to resolve whether micronutrient...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6093353
更新日期:2014-08-26 00:00:00
abstract::The present study aimed to assess energy intake, nutrient profile and food sources in Spanish children participating in the EsNuPI ("Estudio Nutricional en Población Infantil Española") study. Plausibility of energy intake and adequacy of nutrient intakes to international recommendations were analyzed in a final sampl...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040893
更新日期:2020-03-25 00:00:00
abstract:BACKGROUND:Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS:A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010095
更新日期:2018-01-15 00:00:00
abstract::The Editorial Office of Nutrients would like to report an error in the published paper [1] [...]. ...
journal_title:Nutrients
pub_type: 杂志文章,已发布勘误
doi:10.3390/nu10040467
更新日期:2018-04-10 00:00:00
abstract::A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2 µmol/L (9...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9080831
更新日期:2017-08-03 00:00:00
abstract::Advances in web and mobile technologies have created efficiencies relating to collection, analysis and interpretation of dietary intake data. This study compared the impact of two levels of nutrition support: (1) low personalization, comprising a web-based personalized nutrition feedback report generated using the Aus...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113334
更新日期:2020-10-29 00:00:00
abstract::Sofrito is a Mediterranean tomato-based sauce that typically also contains olive oil, onion, and garlic. The preparation of sofrito modifies the bioactive compounds (carotenoids and polyphenols) in the ingredients to more bioavailable forms, promoting cis-lycopene formation and polyphenol bioaccessibility. To evaluate...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu11040851
更新日期:2019-04-15 00:00:00
abstract::Although vitamin B6 is contained in various foods, its deficiency is one of the most common micronutrient deficiencies worldwide. Furthermore, patients with obesity and cardiovascular disease are more likely to have suboptimal vitamin B6 status than healthy people. Therefore, we investigated the effects of dietary vit...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123821
更新日期:2020-12-14 00:00:00
abstract::Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms un...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010200
更新日期:2021-01-11 00:00:00
abstract::Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates cholesterol, triglyceride and phospholipid metabolism in the blood and the brain. APOE gene regulates the expression of this protein and has three different alleles: ε2, ε3 and ε4. Carrying an APOE4 allele is recognised...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6104452
更新日期:2014-10-20 00:00:00