Abstract：
:Altered amino acid levels have been found in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). However, it is not clear whether this alteration is due to altered hepatic metabolism or insulin resistance. The aim of this study was to clarify the association among amino acid levels, fatty liver, and liver fibrosis while eliminating the influence of insulin resistance. NAFLD and liver fibrosis were diagnosed using transient elastography and subjects were divided into three groups: normal, NAFLD, and liver fibrosis. To exclude the influence of insulin resistance, the subjects were matched using the homeostasis model assessment of insulin resistance (HOMA-IR). The amino acid serum levels were compared among the groups. Of 731 enrolled subjects, 251 and 33 were diagnosed with NAFLD and liver fibrosis. Although significant differences were observed among the groups in the serum levels of most amino acids, all but those of glutamate and glycine disappeared after matching for HOMA-IR. The multivariate logistic regression revealed that glutamate, glycine, and HOMA-IR were independent risk factors for liver fibrosis. The altered serum levels of most amino acids were associated with insulin resistance, while the increase in glutamate and the decrease in glycine levels were strongly associated not only with insulin resistance, but also with altered liver metabolism in patients with liver fibrosis.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Hasegawa T,Iino C,Endo T,Mikami K,Kimura M,Sawada N,Nakaji S,Fukuda Sdoi
10.3390/nu12051450subject
Has Abstractpub_date
2020-05-17 00:00:00issue
5issn
2072-6643pii
nu12051450journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：BACKGROUND:Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS:We enrolled 174 patients aged 65 years ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020224
更新日期：2019-01-22 00:00:00
abstract：:Histidine is an essential amino acid (EAA) in mammals, fish, and poultry. We aim to give an overview of the metabolism and physiological effects of histidine in humans and different animal species through a systematic review following the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12051414
更新日期：2020-05-14 00:00:00
abstract：:The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine (Hcy) with and without simultaneous supplementation of B-group vitamins or folic acid. A literature search was conducted in PubMed, EmBase, and Cochrane Central Register of Controlled Trials (CENTRAL) ...
journal_title：Nutrients
pub_type： 杂志文章,meta分析,评审
doi：10.3390/nu8120798
更新日期：2016-12-09 00:00:00
abstract：:Fructose consumption by rodents modulates both hepatic and intestinal lipid metabolism and gluconeogenesis. We have previously demonstrated that in utero exposure to dexamethasone (DEX) interacts with fructose consumption during adult life to exacerbate hepatic steatosis in rats. The aim of this study was to clarify i...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103062
更新日期：2020-10-07 00:00:00
abstract：:Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061197
更新日期：2019-05-28 00:00:00
abstract：:Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to ou...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8100645
更新日期：2016-10-20 00:00:00
abstract：:The association between elevated body mass index (BMI) and risk of death has been reported in many studies. However, the association between BMI and all-cause mortality for hypertensive Chinese adults remains unclear. We conducted a post-hoc analysis using data from the China Stroke Primary Prevention Trial (CSPPT). C...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu8060384
更新日期：2016-06-22 00:00:00
abstract：:The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061795
更新日期：2020-06-17 00:00:00
abstract：:Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010059
更新日期：2020-12-27 00:00:00
abstract：:Taste is influenced by several factors. However, whether habitual exercise level is associated with differences in taste perception has received little investigation. The aim of this study was to determine if habitual exercise is associated with differences in taste perception in men. Active (n = 16) and inactive (n =...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010155
更新日期：2019-01-12 00:00:00
abstract：:Chicken extract, which is rich in anserine and carnosine, has been widely taken in Asian countries as a traditional remedy with various aims, including attenuation of psychological fatigue. The effects of consuming BRAND'S Essence of Chicken (EOC) or a placebo on 46 young adults' responses to a standard psychological ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7020887
更新日期：2015-01-29 00:00:00
abstract：:There is no question that elevated postprandial glycemia is a significant driver of common chronic diseases globally [...]. ...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu12020536
更新日期：2020-02-19 00:00:00
abstract：:The motivation to seek and consume water is an essential component of human fluid-electrolyte homeostasis, optimal function, and health. This review describes the evolution of concepts regarding thirst and drinking behavior, made possible by magnetic resonance imaging, animal models, and novel laboratory techniques. T...
journal_title：Nutrients
pub_type： 历史文章,杂志文章,评审
doi：10.3390/nu11122864
更新日期：2019-11-22 00:00:00
abstract：:Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu5041186
更新日期：2013-04-09 00:00:00
abstract：:Premature and high-risk infants require accurate delivery of nutrients to promote appropriate growth. Continuous enteral feeding methods may result in significant fat and micronutrient loss. This study evaluated fat loss in enteral nutrition using current strategies for providing high-risk infants fortified human milk...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7021174
更新日期：2015-02-11 00:00:00
abstract：:Chronic low-grade inflammation is a primary characteristic of obesity and can lead to other metabolic complications including insulin resistance and type 2 diabetes (T2D). Several anti-inflammatory dietary bioactives decrease inflammation that accompanies metabolic diseases. We are specifically interested in delta-toc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113356
更新日期：2020-10-30 00:00:00
abstract：:Historically, Mangifera indica L. cultivations have been widely planted in tropical areas of India, Africa, Asia, and Central America. However, at least 20 years ago its spreading allowed the development of some cultivars in Sicily, an island to the south of Italy, where the favourable subtropical climate and adapted ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9050525
更新日期：2017-05-20 00:00:00
abstract：:Hypoxia induced by low O2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced me...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123627
更新日期：2020-11-25 00:00:00
abstract：:Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α4ß7 integrin, we te...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102927
更新日期：2020-09-24 00:00:00
abstract：BACKGROUND:prediabetes prevention and management are the main methods used to combat the prevalence of diabetes. Exploratory factor analysis is an upcoming method that is successful in identifying dietary patterns that correlate with healthy or unhealthy outcomes. AIM:this study aims to identify dietary patterns in Ta...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113322
更新日期：2020-10-29 00:00:00
abstract：:Lifestyle interventions have been shown to reverse hyperglycemia to normoglycemia. However, these effects are not long-lasting and are accompanied with high dropout rates. As formula diets have been shown to be simple in usage and effective in improving glycemic control, we hypothesised that adding a low-carbohydrate ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072022
更新日期：2020-07-07 00:00:00
abstract：:Anthropometry (from the Greek anthropos: human, and metron: measure) refers to the systematic collection and correlation of measurements of human individuals, including the systematic measurement of the physical characteristics of the human body, primarily body weight, body size, and shape [...]. ...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu11081891
更新日期：2019-08-14 00:00:00
abstract：:Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081790
更新日期：2019-08-02 00:00:00
abstract：:Endotoxin-induced acute liver injury is mediated by an excessive inflammatory response, hepatocellular oxidative stress, and apoptosis. Traditional medicinal plants have been used to treat various disorders. Platycodon grandifloras (PG) has been shown to be beneficial in relieving cough and asthma and to have anti-tum...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092802
更新日期：2020-09-13 00:00:00
abstract：:Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In recent decades, there has been an exceptional number of ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010139
更新日期：2020-12-31 00:00:00
abstract：:A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 ...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu11102489
更新日期：2019-10-16 00:00:00
abstract：:Many infant formulas are fortified with iron at 8-14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron conten...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010003
更新日期：2020-12-22 00:00:00
abstract：:Fruit and vegetables (F&V) are imperative for good health, yet less than one per cent of Australian children consume these food groups in sufficient quantities. As guided by Social Cognitive Theory (SCT), this paper aimed to: (i) understand key informant perspectives of the amount, types and quality of F&V consumed by...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111603
更新日期：2018-11-01 00:00:00
abstract：:The COVID-19 pandemic is having major economic and personal consequences for collegiate and professional sports. Sporting events have been canceled or postponed, and even when baseball and basketball seasons resumed in the United States recently, no fans were in attendance. As play resumed, several players developed C...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123741
更新日期：2020-12-04 00:00:00
abstract：:Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D, are commonly investigated using animal models induced by a dietary intervention. In spite of significant research contributions, an...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123650
更新日期：2020-11-27 00:00:00
