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Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA²LEN Study.

Abstract：

BACKGROUND:Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS:A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV₁) and FVC (FEV₁/FVC), FVC below lower limit of normal (FVC < LLN), and FEV₁/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA²LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes' procedure was used to test for multiple comparisons. RESULTS:A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV₁/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes' procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. CONCLUSIONS:This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.

journal_name

Nutrients

journal_title

Nutrients

authors

Garcia-Larsen V,Thawer N,Charles D,Cassidy A,van Zele T,Thilsing T,Ahlström M,Haahtela T,Keil T,Matricardi PM,Brożek G,Kowalski ML,Makowska J,Niżankowska-Mogilnicka E,Rymarczyk B,Loureiro C,Todo Bom A,Bachert C,Forsbe

doi

10.3390/nu10010095

subject

Has Abstract

pub_date

2018-01-15 00:00:00

issue

issn

2072-6643

pii

nu10010095

journal_volume

pub_type

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Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA²LEN Study.