Abstract:
BACKGROUND:Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM:To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications. DESIGN:Standard systematic review and narrative synthesis. DATA SOURCES:MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study's inclusion were: conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS/TQ compared to a placebo or other substance. All strains and genders were included. RESULTS:The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review. CONCLUSIONS:Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Cascella M,Palma G,Barbieri A,Bimonte S,Amruthraj NJ,Muzio MR,Del Vecchio V,Rea D,Falco M,Luciano A,Arra C,Cuomo Adoi
10.3390/nu9060625subject
Has Abstractpub_date
2017-06-17 00:00:00issue
6issn
2072-6643pii
nu9060625journal_volume
9pub_type
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