Fiber and Prebiotic Interventions in Pediatric Inflammatory Bowel Disease: What Role Does the Gut Microbiome Play?

Abstract:

:The etiology of inflammatory bowel disease (IBD) is complex but is thought to be linked to an intricate interaction between the host's immune system, resident gut microbiome and environment, i.e., diet. One dietary component that has a major impact on IBD risk and disease management is fiber. Fiber intakes in pediatric IBD patients are suboptimal and often lower than in children without IBD. Fiber also has a significant impact on beneficially shaping gut microbiota composition and functional capacity. The impact is likely to be particularly important in IBD patients, where various studies have demonstrated that an imbalance in the gut microbiome, referred to as dysbiosis, occurs. Microbiome-targeted therapeutics, such as fiber and prebiotics, have the potential to restore the balance in the gut microbiome and enhance host gut health and clinical outcomes. Indeed, studies in adult IBD patients demonstrate that fiber and prebiotics positively alter the microbiome and improve disease course. To date, no studies have been conducted to evaluate the therapeutic potential of fiber and prebiotics in pediatric IBD patients. Consequently, pediatric IBD specific studies that focus on the benefits of fiber and prebiotics on gut microbiome composition and functional capacity and disease outcomes are required.

journal_name

Nutrients

journal_title

Nutrients

authors

Healey GR,Celiberto LS,Lee SM,Jacobson K

doi

10.3390/nu12103204

subject

Has Abstract

pub_date

2020-10-20 00:00:00

issue

10

issn

2072-6643

pii

nu12103204

journal_volume

12

pub_type

杂志文章,评审
  • Activity-Guided Fractionation of Red Fruit Extracts for the Identification of Compounds Influencing Glucose Metabolism.

    abstract::An activity-guided search for compounds influencing glucose metabolism in extracts from aronia (Aronia melanocarpa, A.), pomegranate (Punica granatum L., P.), and red grape (Vitis vinifera, RG) was carried out. The three extracts were fractionated by means of membrane chromatography to separate the anthocyanins from o...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051166

    authors: Ostberg-Potthoff JJ,Berger K,Richling E,Winterhalter P

    更新日期:2019-05-24 00:00:00

  • Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study.

    abstract::Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051032

    authors: Papandreou C,Hernández-Alonso P,Bulló M,Ruiz-Canela M,Yu E,Guasch-Ferré M,Toledo E,Dennis C,Deik A,Clish C,Razquin C,Corella D,Estruch R,Ros E,Fitó M,Arós F,Fiol M,Lapetra J,Ruano C,Liang L,Martínez-González MA,

    更新日期:2019-05-08 00:00:00

  • Diet Quality and Nutrient Intake of Urban Overweight and Obese Primarily African American Older Adults with Osteoarthritis.

    abstract::Diet quality may be a unique target for preventing and managing obesity-related osteoarthritis (OA). Using the Healthy Eating Index-2010 (HEI-2010), this study examined the nutrient intake and diet quality of 400 urban overweight and obese primarily African American older adults with self-reported lower extremity OA. ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10040485

    authors: Vergis S,Schiffer L,White T,McLeod A,Khudeira N,Demott A,Fitzgibbon M,Hughes S,Tussing-Humphreys L

    更新日期:2018-04-13 00:00:00

  • Optimal Vitamin D Supplementation Doses that Minimize the Risk for Both Low and High Serum 25-Hydroxyvitamin D Concentrations in the General Population.

    abstract::The Recommended Dietary Allowance (RDA) is the nutrient intake considered to be sufficient to meet the requirements of 97.5% of the population. Recent reports revealed a statistical error in the calculation of the RDA for vitamin D opening the question of what the recommendation should be. We took a dual approach to a...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7125527

    authors: Veugelers PJ,Pham TM,Ekwaru JP

    更新日期:2015-12-04 00:00:00

  • Influence of Maternal Fish Intake on the Anthropometric Indices of Children in the Western Amazon.

    abstract::We studied trends in fish intake among pregnant women living in the Madeira River Basin in Rondônia State, Brazil, to investigate the influence of maternal fish intake on anthropometric indices of children followed up to 5 years. Maternal fish intake was assessed using hair mercury concentrations of mothers and childr...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10091146

    authors: Cunha MPL,Marques RC,Dórea JG

    更新日期:2018-08-23 00:00:00

  • Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans.

    abstract::Probiotics have been rapidly developed for health promotion, but clinical validation of the effects on exercise physiology has been limited. In a previous study, Lactobacillus plantarum TWK10 (TWK10), isolated from Taiwanese pickled cabbage as a probiotic, was demonstrated to improve exercise performance in an animal ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu11112836

    authors: Huang WC,Lee MC,Lee CC,Ng KS,Hsu YJ,Tsai TY,Young SL,Lin JS,Huang CC

    更新日期:2019-11-19 00:00:00

  • Zinc Nutritional Status in Patients with Cystic Fibrosis.

    abstract:BACKGROUND:Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. OBJECTIVE:The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010150

    authors: Escobedo Monge MF,Barrado E,Alonso Vicente C,Redondo Del Río MP,Marugán de Miguelsanz JM

    更新日期:2019-01-11 00:00:00

  • Supplementation with Saccharomyces boulardii Increases the Maximal Oxygen Consumption and Maximal Aerobic Speed Attained by Rats Subjected to an Incremental-Speed Exercise.

    abstract::Benefits to the host metabolism resulting from Saccharomyces boulardii (Sb) supplementation have been described; however, no study has investigated the effects of this supplementation on aerobic metabolism and performance during physical exercise. Thus, in the present study, we addressed the effects of Sb supplementat...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11102352

    authors: Soares ADN,Wanner SP,Morais ESS,Hudson ASR,Martins FS,Cardoso VN

    更新日期:2019-10-02 00:00:00

  • Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats.

    abstract::Osteoarthritis (OA) has become one of the most common disabilities among elders, especially in females. Obesity and mechanical injuries caused by OA are attributed to joint loading, cartilage disintegration, and bone loss, as well as inflammation. Pharmacological and non-pharmacological treatments can be used for OA. ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10060686

    authors: Sudirman S,Ong AD,Chang HW,Kong ZL

    更新日期:2018-05-28 00:00:00

  • Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis.

    abstract::Epidemiological studies have provided ambiguous evidence on the association between vitamin E and esophageal cancer risk. To resolve this controversy, we performed this meta-analysis. The literature was searched by using Excerpta Medica Database (EMBASE), PubMed, the Web of Science, and the Cochrane Library from the i...

    journal_title:Nutrients

    pub_type: 杂志文章,meta分析

    doi:10.3390/nu10070801

    authors: Cui L,Li L,Tian Y,Xu F,Qiao T

    更新日期:2018-06-21 00:00:00

  • Food intake of Kansans over 80 years of age attending congregate meal sites.

    abstract::As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans,...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu2121297

    authors: Weeden AM,Remig VM

    更新日期:2010-12-01 00:00:00

  • Restrained Eating and Vegan, Vegetarian and Omnivore Dietary Intakes.

    abstract::There are a significant number of studies on cognitive restraint among individuals with varying dietary patterns. Although most research has found that vegetarians report higher levels of cognitive restraint compared to non-vegetarians, many studies have contributed inconsistent results. The aim of the current study, ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12072133

    authors: Brytek-Matera A

    更新日期:2020-07-17 00:00:00

  • Less Animal-Based Food, Better Weight Status: Associations of the Restriction of Animal-Based Product Intake with Body-Mass-Index, Depressive Symptoms and Personality in the General Population.

    abstract::Restricting animal-based products from diet may exert beneficial effects on weight status; however, less is known about such a diet and emotional health. Moreover, personality traits, for example high neuroticism, may contribute to restrictive eating habits and potentially confound diet-health associations. We aim to ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051492

    authors: Medawar E,Enzenbach C,Roehr S,Villringer A,Riedel-Heller SG,Witte AV

    更新日期:2020-05-20 00:00:00

  • Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

    abstract::Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu7115458

    authors: Grandone A,Marzuillo P,Perrone L,Del Giudice EM

    更新日期:2015-11-06 00:00:00

  • Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1.

    abstract::Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In th...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010060

    authors: Zhao P,Alam MB,Lee SH

    更新日期:2018-12-28 00:00:00

  • Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life.

    abstract::Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though t...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12041045

    authors: Kleist SA,Knoop KA

    更新日期:2020-04-10 00:00:00

  • Association of Low Serum l-Carnitine Levels with Peripheral Arterial Stiffness in Patients Who Undergo Kidney Transplantation.

    abstract::l-carnitine is an important co-factor in fatty-acid metabolism, and its deficiency is associated with insulin resistance, which is independently associated with arterial stiffness. This study evaluated the relationship between serum l-carnitine level and peripheral arterial stiffness (PAS) in kidney transplantation (K...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11092000

    authors: Lai YH,Lee MC,Ho GJ,Liu CH,Hsu BG

    更新日期:2019-08-24 00:00:00

  • Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas.

    abstract::The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of bot...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12030862

    authors: Trzeciak M,Olszewska B,Sakowicz-Burkiewicz M,Sokołowska-Wojdyło M,Jankau J,Nowicki RJ,Pawełczyk T

    更新日期:2020-03-24 00:00:00

  • A Web-Based 24-H Dietary Recall Could Be a Valid Tool for the Indicative Assessment of Dietary Intake in Older Adults Living in Slovenia.

    abstract::The methodology used in dietary surveys could, to a large extent, follow the instructions of the European Food Safety Authority (EFSA), where 24-h dietary recall (24HDR) is recommended for (sub) population studies. However, it is necessary to examine the suitability of 24HDR for indicative dietary intake in older adul...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11092234

    authors: Gregorič M,Zdešar Kotnik K,Pigac I,Gabrijelčič Blenkuš M

    更新日期:2019-09-16 00:00:00

  • Effects of (-)-Epigallocatechin Gallate (EGCG) on Energy Expenditure and Microglia-Mediated Hypothalamic Inflammation in Mice Fed a High-Fat Diet.

    abstract::Obesity is an escalating global epidemic caused by an imbalance between energy intake and expenditure. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been reported to be conducive to preventing obesity and alleviating obesity-related chronic diseases. However, the role of EGCG in energy ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10111681

    authors: Zhou J,Mao L,Xu P,Wang Y

    更新日期:2018-11-05 00:00:00

  • Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats.

    abstract::Tocotrienols have been reported to improve lipid profiles, reduce atherosclerotic lesions, decrease blood glucose and glycated haemoglobin concentrations, normalise blood pressure in vivo and inhibit adipogenesis in vitro, yet their role in the metabolic syndrome has not been investigated. In this study, we investigat...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu4101527

    authors: Wong WY,Poudyal H,Ward LC,Brown L

    更新日期:2012-10-22 00:00:00

  • A Mixture of Humulus japonicus Increases Longitudinal Bone Growth Rate in Sprague Dawley Rats.

    abstract::The aim of this study was to investigate the effects of administration of a mixture of Humulus japonicus (MH) on longitudinal bone growth in normal Sprague Dawley (SD) rats. We measured the femur and tibia length, growth plate area, proliferation of chondrocytes, and expression of insulin-like growth factor-1 (IGF-I) ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092625

    authors: Kim OK,Yun JM,Lee M,Park SJ,Kim D,Oh DH,Kim HS,Kim GY

    更新日期:2020-08-28 00:00:00

  • 1H NMR fingerprinting of soybean extracts, with emphasis on identification and quantification of isoflavones.

    abstract::1H NMR spectra were recorded of methanolic extracts of seven soybean varieties (Glycine max.), cultivated using traditional and organic farming techniques. It was possible to identify signals belonging to the groups of amino acids, carbohydrates, organic acids and aromatic substances in the spectra. In the aromatic zo...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu2030280

    authors: Caligiani A,Palla G,Maietti A,Cirlini M,Brandolini V

    更新日期:2010-03-01 00:00:00

  • Accuracy of the Resting Energy Expenditure Estimation Equations for Healthy Women.

    abstract:BACKGROUND:There exist several prediction equations for the estimation of resting energy expenditure (REE). However, none of these equations have been validated in the Chilean female population yet. The aims of this study are (1) to determine the accuracy of existing equations for prediction of REE and (2) to develop n...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13020345

    authors: Molina-Luque R,Carrasco-Marín F,Márquez-Urrizola C,Ulloa N,Romero-Saldaña M,Molina-Recio G

    更新日期:2021-01-24 00:00:00

  • Dietary Diversity among Chinese Residents during the COVID-19 Outbreak and Its Associated Factors.

    abstract::COVID-19, a Public Health Emergency of International Concern, has imposed enormous challenges on the health system, economy, and food supply and has substantially modified people's lifestyles. This study aimed to (1) explore the dietary diversity during the lockdown time in China and (2) examine factors associated wit...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061699

    authors: Zhao A,Li Z,Ke Y,Huo S,Ma Y,Zhang Y,Zhang J,Ren Z

    更新日期:2020-06-06 00:00:00

  • Effect of Micronutrient Powder (MNP) with a Low-Dose of Iron on Hemoglobin and Iron Biomarkers, and Its Effect on Morbidities in Rural Bangladeshi Children Drinking Groundwater with a High-Level of Iron: A Randomized Controlled Trial.

    abstract::Micronutrient Powder (MNP) is beneficial to control anemia, but some iron-related side-effects are common. A high level of iron in the groundwater used for drinking may exacerbate the side-effects among MNP users. We conducted a randomized controlled trial examining the effect of a low-dose iron MNP compared with the ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu11112756

    authors: Rahman S,Lee P,Raqib R,Roy AK,Khan MR,Ahmed F

    更新日期:2019-11-13 00:00:00

  • Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene.

    abstract::In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11051093

    authors: Meléndez-Martínez AJ,Stinco CM,Mapelli-Brahm P

    更新日期:2019-05-16 00:00:00

  • Heterozygotes Are a Potential New Entity among Homozygotes and Compound Heterozygotes in Congenital Sucrase-Isomaltase Deficiency.

    abstract::Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder of carbohydrate maldigestion and malabsorption caused by mutations in the sucrase-isomaltase (SI) gene. SI, together with maltase-glucoamylase (MGAM), belongs to the enzyme family of disaccharidases required for breakdown of -glycosidi...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11102290

    authors: Husein DM,Wanes D,Marten LM,Zimmer KP,Naim HY

    更新日期:2019-09-25 00:00:00

  • Excessive Weight Gain Followed by Catch-Down in Exclusively Breastfed Infants: An Exploratory Study.

    abstract::Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group)....

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10091290

    authors: Larsson MW,Lind MV,Larnkjær A,Due AP,Blom IC,Wells J,Lai CT,Mølgaard C,Geddes DT,Michaelsen KF

    更新日期:2018-09-12 00:00:00

  • Associations between Dietary Patterns and Bile Acids-Results from a Cross-Sectional Study in Vegans and Omnivores.

    abstract::Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. This study investigated concentrations of fecal and serum bile acids in 36 vegans and 36 omnivores. The reduced rank regression was used to iden...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12010047

    authors: Trefflich I,Marschall HU,Giuseppe RD,Ståhlman M,Michalsen A,Lampen A,Abraham K,Weikert C

    更新日期:2019-12-23 00:00:00