Abstract：
:Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder of carbohydrate maldigestion and malabsorption caused by mutations in the sucrase-isomaltase (SI) gene. SI, together with maltase-glucoamylase (MGAM), belongs to the enzyme family of disaccharidases required for breakdown of -glycosidic linkages in the small intestine. The effects of homozygote and compound heterozygote inheritance trait of SI mutations in CSID patients have been well described in former studies. Here we propose the inclusion of heterozygote mutation carriers as a new entity in CSID, possibly presenting with milder symptoms. The hypothesis is supported by recent observations of heterozygote mutation carriers among patients suffering from CSID or patients diagnosed with functional gastrointestinal disorders. Recent studies implicate significant phenotypic heterogeneity depending on the character of the mutation and call for more research regarding the correlation of genetics, function at the cellular and molecular level and clinical presentation. The increased importance of SI gene variants in irritable bowel syndrome (IBS) or other functional gastrointestinal disorders FGIDs and their available symptom relief diets like fermentable oligo-, di-, mono-saccharides and polyols FODMAPs suggest that the heterozygote mutants may affect the disease development and treatment.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Husein DM,Wanes D,Marten LM,Zimmer KP,Naim HYdoi
10.3390/nu11102290subject
Has Abstractpub_date
2019-09-25 00:00:00issue
10issn
2072-6643pii
nu11102290journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Vitamin D and calcium supplementation have been posited to improve body composition and different formulations of calcium may impact bioavailability. However, data are lacking regarding the combinatorial effects of exercise, diet, and calcium and/or vitamin D supplementation on body composition changes in post-menopau...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030713
更新日期：2020-03-07 00:00:00
abstract：:Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus (CRV) possess a high phenolic compound content with excellent antioxidant activity. Dietary antioxidants can reduce exercise-induced oxidative stress. Consumption of large amounts of phenolic compounds is positively correlated with reduction in exercise-indu...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081715
更新日期：2019-07-25 00:00:00
abstract：:Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111570
更新日期：2018-10-23 00:00:00
abstract：:The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of bot...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030862
更新日期：2020-03-24 00:00:00
abstract：:The aims of this study were to assess the diagnostic value of the weight-to-height ratio (WHtR) for the detection of obesity and metabolic syndrome (MS) in Korean children and adolescents, and to determine the advantages of WHtR as a population-based screening tool in comparison with other obesity indicators, such as ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9030256
更新日期：2017-03-10 00:00:00
abstract：:Recent studies continue to demonstrate the potential of edible insects as a protein base to obtain bioactive peptides applicable for functional food development. This study aimed at identifying antihypertensive, anti-glycemic, and anti-inflammatory peptides derived from the in vitro gastrointestinal digests of cricket...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113588
更新日期：2020-11-23 00:00:00
abstract：:It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been asso...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2040408
更新日期：2010-04-01 00:00:00
abstract：:Harman and norharman, two neuroactive β-carbolines, are present in several plants and in thermally processed foods. They exhibited a wide spectrum of biological and pharmacological effects, including antioxidant, neuroprotective, and anti-inflammatory effects. In this article, we review the progress of recent research...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11040814
更新日期：2019-04-11 00:00:00
abstract：:Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasmino...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7125512
更新日期：2015-12-02 00:00:00
abstract：:High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered les...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7115480
更新日期：2015-11-16 00:00:00
abstract：:Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive po...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3390/nu7085303
更新日期：2015-08-10 00:00:00
abstract：:Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and non...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12041105
更新日期：2020-04-16 00:00:00
abstract：:The COVID-19 pandemic has disrupted many aspects of daily life. The purpose of this study was to identify how health behaviors, level of stress, financial and food security have been impacted by the pandemic among Canadian families with young children. Parents (mothers, n = 235 and fathers, n = 126) from 254 families ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082352
更新日期：2020-08-07 00:00:00
abstract：:A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8090577
更新日期：2016-09-20 00:00:00
abstract：:Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease the environmental impact of animal agriculture, but also exert biological activities with significant health-beneficial effects. Wheat is the most important food grain source in the world. However, n...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061673
更新日期：2020-06-04 00:00:00
abstract：:Long-chain (LC) omega-3 PUFA derived from marine sources may play an important role in cognitive performance throughout all life stages. Docosahexaenoic acid (DHA), the dominant omega-3 in the brain, is a major component of neuronal cell membranes and affects various neurological pathways and processess. Despite its c...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6072730
更新日期：2014-07-22 00:00:00
abstract：:Patients with metabolic syndrome are at an increased risk of developing type 2 diabetes and cardiovascular diseases. The principal risk factor for development of metabolic syndrome is obesity, defined as a state of pathological hyperplasia or/and hypertrophy of adipose tissue. The number of mature adipocytes is determ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102307
更新日期：2019-09-28 00:00:00
abstract：:While studies revealed that the omega-3 polyunsaturated fatty acids (n-3 PUFA) and their mediators would be able to regulate several biological processes involved into the development of postpartum depression (PPD), evidence from observational studies remains mixed. The aim of the present study was to investigate the ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040876
更新日期：2019-04-18 00:00:00
abstract：:This study investigated the effects of a single dose of arginine (Arg) administration at the beginning of sepsis on CD4+ T-cell regulation and liver inflammation in C57BL/6J mice. Mice were divided into normal control (NC), sham (SH), sepsis saline (SS), and sepsis Arg (SA) groups. An inducible nitric oxide (NO) synth...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041047
更新日期：2020-04-10 00:00:00
abstract：:The aim of this 12-month retrospective study was to evaluate differences in the outcomes of denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients having osteoporosis (OP) with rheumatoid arthritis (RA). Patients were divided into the denosumab monotherapy group (denosumab group, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9050428
更新日期：2017-04-26 00:00:00
abstract：:Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 54...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020441
更新日期：2019-02-20 00:00:00
abstract：:Responsive feeding is crucial to the formation of life-long healthy eating behavior. Few studies have examined maternal responsive feeding in early infancy among a Chinese population. This prospective study describes maternal responsive feeding and factors associated with maternal responsive feeding, with emphasis on ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061766
更新日期：2020-06-12 00:00:00
abstract：:Dietary record tools such as food frequency questionnaire (FFQ) and food diaries (FD) are the most commonly used choices for assessing dietary intakes in most large-scale epidemiological studies. The authors developed a self-administered 360-item food frequency questionnaire (FFQ) to assess dietary intakes amongst a p...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020383
更新日期：2020-01-31 00:00:00
abstract：:A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hy...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041056
更新日期：2020-04-10 00:00:00
abstract：:Accuracy in measuring intake of dietary constituents is an important issue in studies reporting the associations between diet and chronic diseases. We modified a Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire (FFQ) to include foods of interest in the field of Alzheime...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123605
更新日期：2020-11-24 00:00:00
abstract：:Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without causing e...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6114856
更新日期：2014-11-04 00:00:00
abstract：:Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, acts as an antagonist for both the α7 nicotinic acetylcholine receptor and glycine coagonist sites of the N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Elevation of brain kynurenic acid levels reduces the release o...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12051403
更新日期：2020-05-13 00:00:00
abstract：:The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061795
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071555
更新日期：2019-07-10 00:00:00
abstract：BACKGROUND:The main goal of this study was to assess the acute effects of the intake of 9 and 11 mg/kg/ body mass (b.m.) of caffeine (CAF) on maximal strength and muscle endurance in athletes habituated to caffeine. METHODS:The study included 16 healthy strength-trained male athletes (age = 24.2 ± 4.2 years, body mass...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11081912
更新日期：2019-08-15 00:00:00
