Abstract：
:Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, acts as an antagonist for both the α7 nicotinic acetylcholine receptor and glycine coagonist sites of the N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Elevation of brain kynurenic acid levels reduces the release of neurotransmitters such as dopamine and glutamate, and kynurenic acid is considered to be involved in psychiatric disorders such as schizophrenia and depression. Thus, the control of kynurenine pathway, especially kynurenic acid production, in the brain is an important target for the improvement of brain function or the effective treatment of brain disorders. Astrocytes uptake kynurenine, the immediate precursor of kynurenic acid, via large neutral amino acid transporters, and metabolize kynurenine to kynurenic acid by kynurenine aminotransferases. The former transport both branched-chain and aromatic amino acids, and the latter have substrate specificity for amino acids and their metabolites. Recent studies have suggested the possibility that amino acids may suppress kynurenic acid production via the blockade of kynurenine transport or via kynurenic acid synthesis reactions. This approach may be useful in the treatment and prevention of neurological and psychiatric diseases associated with elevated kynurenic acid levels.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Fukuwatari Tdoi
10.3390/nu12051403subject
Has Abstractpub_date
2020-05-13 00:00:00issue
5issn
2072-6643pii
nu12051403journal_volume
12pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract：:While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-a...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11061436
更新日期：2019-06-25 00:00:00
abstract：:Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12041045
更新日期：2020-04-10 00:00:00
abstract：OBJECTIVE:Type 2 diabetes mellitus (T2DM) is thought to arise from the complex interplay between genetic and environmental factors. It is important to identify modifiable risk factors that may help to reduce the risk of diabetes. Data on salt intake and the risk of type 2 diabetes are limited. The aim of this study was...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010067
更新日期：2017-01-13 00:00:00
abstract：:Kiwifruit are a rich source of vitamin C and also contain numerous phytochemicals, such as flavonoids, which may influence the bioavailability of kiwifruit-derived vitamin C. The aim of this study was to compare the relative bioavailability of synthetic versus kiwifruit-derived vitamin C using a randomised cross-over ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu5114451
更新日期：2013-11-11 00:00:00
abstract：:Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal defic...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6093818
更新日期：2014-09-19 00:00:00
abstract：:Although fruit and vegetable consumption is highly recommended for a healthy and balanced daily diet, several European countries do not meet these recommendations. In Italy, only 45% of young people are consuming at least one portion of vegetables per day. Therefore, this paper aims to understand the main determinants...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7095357
更新日期：2015-09-10 00:00:00
abstract：:Few studies have been reported on alterations of trace elements (TE) in peritoneal dialysis patients. Our objective was to investigate and assess the characteristics of daily TE excretions in continuous ambulatory peritoneal dialysis (CAPD) patients. This cross-sectional study included 61 CAPD patients (nonanuric/anur...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8120826
更新日期：2016-12-20 00:00:00
abstract：:Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus Lactobacillus. This work presents the compiled and analysed results from the most up-to-date information from clinical trial...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030757
更新日期：2020-03-13 00:00:00
abstract：:Susceptibility to develop hypertension may be established during early stages of life that include the intrauterine period, infancy and childhood. We recently showed that blood pressure increased when rats reached adulthood when sucrose was ingested for a short-term critical window from postnatal day 12 to 28 in the r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020309
更新日期：2019-02-01 00:00:00
abstract：:Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasmino...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7125512
更新日期：2015-12-02 00:00:00
abstract：:Our purpose was to study the relationship of adherence to the Mediterranean diet (MedDiet) with urinary factors that favor the formation of renal calcium and uric acid stones in overweight and obese participants who had metabolic syndrome. This cross-sectional study examined 267 participants. A well-known MedDiet scor...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu11081708
更新日期：2019-07-24 00:00:00
abstract：:Emerging research demonstrates polyphenol-rich diets like the Mediterranean diet may play a role in improving the outcomes of adult cancer therapy. To date, there are no trials assessing the intake or efficacy of polyphenol-rich diets in childhood cancer patients. In this study we collected dietary data on 59 childhoo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112835
更新日期：2019-11-19 00:00:00
abstract：:Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whos...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061706
更新日期：2020-06-07 00:00:00
abstract：BACKGROUND:Olive oil-based lipid emulsion (LE) and medium chain triglyceride/long chain triglyceride (MCT/LCT) emulsion are both LEs with low ω-6 polyunsaturated fat acids (PUFAs) content. However, which one of these LEs is associated with a lower infection risk in patients receiving parenteral nutrition (PN) remains u...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu6010111
更新日期：2013-12-27 00:00:00
abstract：BACKGROUND:The prevalence of anorexia nervosa among males is increasing but few data are available in the literature. This cross sectional study aims to evaluate resting energy expenditure (REE) and phase angle as a marker of qualitative changes of fat free mass (FFM) in three leanness groups as compared with control s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030502
更新日期：2019-02-27 00:00:00
abstract：:Dietary carotenoids, plant pigments with anti-oxidant properties, accumulate in neural tissue and are often found in lower concentrations among individuals with obesity. Given previous evidence of negative associations between excess adiposity and memory, it is possible that greater carotenoid status may confer neurop...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040768
更新日期：2019-04-02 00:00:00
abstract：:Tocotrienols have been reported to improve lipid profiles, reduce atherosclerotic lesions, decrease blood glucose and glycated haemoglobin concentrations, normalise blood pressure in vivo and inhibit adipogenesis in vitro, yet their role in the metabolic syndrome has not been investigated. In this study, we investigat...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4101527
更新日期：2012-10-22 00:00:00
abstract：:The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081836
更新日期：2019-08-08 00:00:00
abstract：:Selenium, an essential trace element known mainly for its antioxidant properties, is critical for proper brain function and regulation of energy metabolism. Whole-body knockout of the selenium recycling enzyme, selenocysteine lyase (Scly), increases susceptibility to metabolic syndrome and diet-induced obesity in mice...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071693
更新日期：2019-07-23 00:00:00
abstract：:The effects of allulose and two probiotic species on diet-induced obese (DIO) mice were investigated. Lactobacillus sakei LS03 (10⁸ cfu/day) and Leuconostoc kimchii GJ2 (10⁸ cfu/day) were used as probiotics, and allulose (AL) as a prebiotic. The synergistic effect of prebiotics and probiotics in improving obesity was ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111797
更新日期：2018-11-19 00:00:00
abstract：:The sense of food insecurity in a group of elderly people may be determined by the perception of distance to food outlets. The aim of the study was to assess the relationship between the perception of food insecurity by the elderly and their perception of the distance between the places of residence and food purchase....
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103191
更新日期：2020-10-19 00:00:00
abstract：:In this study, we aimed to examine the effect of vitamin D deficiency on all-cause mortality in ankylosing spondylitis (AS) patients and in the general population. This is a retrospective-cohort study based on the electronic database of the largest health-maintenance organization in Israel. AS patients who were first ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051400
更新日期：2020-05-13 00:00:00
abstract：:The mechanism by which high fat-diet induced obesity affects cardiac protein expression is unclear, and the extent to which this is modulated by prebiotic treatment is not known. These outcomes were assessed in rats initially fed a high-fat diet, then the top 40% weight gain group were randomly allocated to control (C...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113404
更新日期：2020-11-05 00:00:00
abstract：:Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antiox...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030682
更新日期：2020-03-03 00:00:00
abstract：:Gut appetite hormone responses may be influenced by meal macronutrients and obesity. The primary aim of this study was to examine in adolescents with obesity and of healthy weight the effect of a high-protein and a high-carbohydrate meal on postprandial gut appetite hormones. A postprandial cross-over study with adole...
journal_title：Nutrients
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3390/nu11020340
更新日期：2019-02-05 00:00:00
abstract：:Gluten-related neurological disorders (GRND) represent a spectrum of neurological manifestations that are triggered by gluten. In coeliac disease, a T-cell mediated enteropathy is triggered by gluten in genetically predisposed individuals. The underlying pathological mechanism of the neurological dysfunction is not ye...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu12030822
更新日期：2020-03-20 00:00:00
abstract：:Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fal...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12102929
更新日期：2020-09-24 00:00:00
abstract：:Sialic acid (SA) is an integral component of gangliosides and signaling molecules in the brain and its dietary intake may support cognitive development. We previously reported that feeding sialyllactose, a milk oligosaccharide that contains SA, alters SA content and diffusivity in the pig brain. The present research s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040395
更新日期：2018-03-23 00:00:00
abstract：:Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc intake, as well as serum/plasma and whole blood zinc concentration, and risk of T2DM. Observational studies, conducted on ...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11051027
更新日期：2019-05-08 00:00:00
abstract：BACKGROUND:Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway i...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu11071678
更新日期：2019-07-22 00:00:00
