Abstract：
:Tocotrienols have been reported to improve lipid profiles, reduce atherosclerotic lesions, decrease blood glucose and glycated haemoglobin concentrations, normalise blood pressure in vivo and inhibit adipogenesis in vitro, yet their role in the metabolic syndrome has not been investigated. In this study, we investigated the effects of palm tocotrienol-rich fraction (TRF) on high carbohydrate, high fat diet-induced metabolic, cardiovascular and liver dysfunction in rats. Rats fed a high carbohydrate, high fat diet for 16 weeks developed abdominal obesity, hypertension, impaired glucose and insulin tolerance with increased ventricular stiffness, lower systolic function and reduced liver function. TRF treatment improved ventricular function, attenuated cardiac stiffness and hypertension, and improved glucose and insulin tolerance, with reduced left ventricular collagen deposition and inflammatory cell infiltration. TRF improved liver structure and function with reduced plasma liver enzymes, inflammatory cell infiltration, fat vacuoles and balloon hepatocytes. TRF reduced plasma free fatty acid and triglyceride concentrations but only omental fat deposition was decreased in the abdomen. These results suggest that tocotrienols protect the heart and liver, and improve plasma glucose and lipid profiles with minimal changes in abdominal obesity in this model of human metabolic syndrome.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Wong WY,Poudyal H,Ward LC,Brown Ldoi
10.3390/nu4101527subject
Has Abstractpub_date
2012-10-22 00:00:00pages
1527-41issue
10issn
2072-6643pii
nu4101527journal_volume
4pub_type
杂志文章相关文献
Nutrients文献大全abstract：BACKGROUND:Oral uptake of lycopene has been shown to be beneficial for preventing myocardial ischemia-reperfusion (I/R) injury. However, the strong first-pass metabolism of lycopene influences its bioavailability and impedes its clinic application. In this study, we determined an intravenous (IV) administration dose of...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8030138
更新日期：2016-03-03 00:00:00
abstract：:The rating of perceived exertion (RPE) indicates the feeling of fatigue. However, hypoxia worsens the condition and can worsen RPE. We evaluated whether carbohydrate and glutamine supplementation alters RPE and physiological markers in running at 70% peak oxygen uptake until exhaustion in a simulated altitude of 4500 ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123797
更新日期：2020-12-11 00:00:00
abstract：:Food intake biomarkers (FIBs) can reflect the intake of specific foods or dietary patterns (DP). DP for successful aging (SA) has been widely studied. However, the relationship between SA and DP characterized by FIBs still needs further exploration as the candidate markers are scarce. Thus, 1H-nuclear magnetic resonan...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102900
更新日期：2020-09-23 00:00:00
abstract：:This study investigated the effect of the sodium to potassium ratio on hypertension prevalence and blood pressure. The study population was constructed by pooling the Korean National Health and Nutrition Examination Surveys between 2010 and 2014. The study population was divided into quartiles based on the sodium to p...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8080482
更新日期：2016-08-06 00:00:00
abstract：:Malnutrition among heart-transplant patients may affect survival. The aim was to investigate the survival and nutrition status among male and female heart transplant patients who underwent transplantation, before and 1 year after surgery based on the nutritional risk index (NRI). The medical records of ninety heart-tr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123868
更新日期：2020-12-17 00:00:00
abstract：:A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to ...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11040708
更新日期：2019-03-27 00:00:00
abstract：:Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on di...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113297
更新日期：2020-10-28 00:00:00
abstract：BACKGROUND:Fruits and vegetables are key to a healthy diet, particularly in children; however, parents may be concerned about contaminants found in fruits and vegetables. Making informed food choices for children requires understanding and balancing the risks of contaminant exposure with the importance of providing a h...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111572
更新日期：2018-10-24 00:00:00
abstract：:Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the associ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11050966
更新日期：2019-04-27 00:00:00
abstract：:In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2070725
更新日期：2010-07-01 00:00:00
abstract：:Dear Editors and Authors, I had the pleasure to read the published article entitled [1] "Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis" [...]. ...
journal_title：Nutrients
pub_type： 评论,信件
doi：10.3390/nu10030312
更新日期：2018-03-06 00:00:00
abstract：:Prolonged effects of dietary acid intake on acid-base status and kidney function have not yet been studied in an intervention study in healthy subjects. Dietary acid load can be estimated by calculating the potential renal acid load (PRAL) of foods. Effects of low-PRAL and moderate-PRAL diets on acid-base status and k...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10030323
更新日期：2018-03-08 00:00:00
abstract：:Fructose consumption by rodents modulates both hepatic and intestinal lipid metabolism and gluconeogenesis. We have previously demonstrated that in utero exposure to dexamethasone (DEX) interacts with fructose consumption during adult life to exacerbate hepatic steatosis in rats. The aim of this study was to clarify i...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103062
更新日期：2020-10-07 00:00:00
abstract：:The recruitment and infiltration of classical monocytes into damaged muscle is critical for optimal tissue remodeling. This study examined the effects of an amino acid supplement on classical monocyte recruitment following an acute bout of lower body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 years; 9...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu8070409
更新日期：2016-07-02 00:00:00
abstract：:Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot stu...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11061386
更新日期：2019-06-20 00:00:00
abstract：BACKGROUND:The prevalence of anorexia nervosa among males is increasing but few data are available in the literature. This cross sectional study aims to evaluate resting energy expenditure (REE) and phase angle as a marker of qualitative changes of fat free mass (FFM) in three leanness groups as compared with control s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030502
更新日期：2019-02-27 00:00:00
abstract：:Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid⁻base balance. Major det...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10040512
更新日期：2018-04-20 00:00:00
abstract：:Even though irritable bowel syndrome (IBS) has been known for more than 150 years, it still remains one of the research challenges of the 21st century. According to the current diagnostic Rome IV criteria, IBS is characterized by abdominal pain associated with defecation and/or a change in bowel habit, in the absence ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092162
更新日期：2019-09-09 00:00:00
abstract：:This article describes the important cultural specifics that impact on treatment of overweight and obesity for the Roma people of South Bohemia. METHODS:Data on health and nutrition were collected using a semi-structured interview of 302 Roma adults (quantitative phase). A further 25 participants received in-depth in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10070838
更新日期：2018-06-28 00:00:00
abstract：BACKGROUND:this study examined the effects of caffeine supplementation on anaerobic performance, neuromuscular efficiency and upper and lower extremities fatigue in Olympic-level boxers. METHODS:Eight male athletes, members of the Spanish National Olympic Team, were enrolled in the study. In a randomized double-blind,...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11092120
更新日期：2019-09-05 00:00:00
abstract：:The authors have requested that the following changes be made to their paper [...]. ...
journal_title：Nutrients
pub_type： 已发布勘误
doi：10.3390/nu11123021
更新日期：2019-12-10 00:00:00
abstract：:Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five ob...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030580
更新日期：2019-03-08 00:00:00
abstract：:Copper, which can potentially be a highly toxic agent, is an essential nutrient due to its role as a cofactor for cuproenzymes and its participation in signaling pathways. In mammals, the liver is a central organ that controls copper turnover throughout the body, including copper absorption, distribution, and excretio...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10111591
更新日期：2018-10-30 00:00:00
abstract：:The mechanism by which high fat-diet induced obesity affects cardiac protein expression is unclear, and the extent to which this is modulated by prebiotic treatment is not known. These outcomes were assessed in rats initially fed a high-fat diet, then the top 40% weight gain group were randomly allocated to control (C...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113404
更新日期：2020-11-05 00:00:00
abstract：:Cyanidin is a natural anthocyanidin present in fruits and vegetables with anti-diabetic properties including stimulation of insulin secretion. However, its mechanism of action remains unknown. In this study, we elucidated the mechanisms of cyanidin for stimulatory insulin secretion from pancreatic β-cells. Rat pancrea...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9080814
更新日期：2017-07-28 00:00:00
abstract：:The mango leaf extract rich in mangiferin Zynamite® improves exercise performance when combined with luteolin or quercetin ingested at least 48 h prior to exercise. To determine whether a single dose of Zynamite® administered 1 h before exercise increases repeated-sprint performance, 20 men and 20 women who were physi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112592
更新日期：2019-10-28 00:00:00
abstract：:Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the relationships between IHD and anemia. In a cluster survey of chil...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9070693
更新日期：2017-07-03 00:00:00
abstract：:Few studies have examined docosahexaenoic acid (DHA) in pregnant and lactating women in developing countries like China, where DHA-enriched supplements are increasingly popular. We aimed to assess the DHA status among Chinese pregnant and lactating women residing areas differing in the availability of aquatic products...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7105428
更新日期：2015-10-21 00:00:00
abstract：:Obesity is not the same in all individuals and two different phenotypes have been described: metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). The aim of this study was to identify factors that explain metabolic health status in a rigorously matched Spanish population. Subcutaneous and vis...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010119
更新日期：2020-12-31 00:00:00
abstract：:Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8050291
更新日期：2016-05-13 00:00:00
