Abstract:
:In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Nakamura YK,Omaye STdoi
10.3390/nu2070725subject
Has Abstractpub_date
2010-07-01 00:00:00pages
725-36issue
7issn
2072-6643pii
nu2070725journal_volume
2pub_type
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