Lipophilic compound-mediated gene expression and implication for intervention in reactive oxygen species (ROS)-related diseases: mini-review.

Abstract:

:In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.

journal_name

Nutrients

journal_title

Nutrients

authors

Nakamura YK,Omaye ST

doi

10.3390/nu2070725

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

725-36

issue

7

issn

2072-6643

pii

nu2070725

journal_volume

2

pub_type

杂志文章,评审