Abstract:
:Modulation of the gut microbiota through the use of probiotics has been widely used to treat or prevent several intestinal diseases. However, inconsistent results have compromised the efficacy of this approach, especially in severe conditions such as inflammatory bowel disease (IBD). The purpose of our study was to develop a personalized probiotic strategy and assess its efficacy in a murine model of intestinal inflammation. Commensal bacterial strains were isolated from the feces of healthy mice and then administered back to the host as a personalized treatment in dextran sodium sulfate (DSS)-induced colitis. Colonic tissues were collected for histological analysis and to investigate inflammatory markers such as Il-1β, Il-6, TGF-β, and Il-10, and the enzyme myeloperoxidase as a neutrophil marker. The group that received the personalized probiotic showed reduced susceptibility to DSS-colitis as compared to a commercial probiotic. This protection was characterized by a lower disease activity index and reduced histopathological damage in the colon. Moreover, the personalized probiotic was more effective in modulating the host immune response, leading to decreased Il-1β and Il-6 and increased TGF-β and Il-10 expression. In conclusion, our study suggests that personalized probiotics may possess an advantage over commercial probiotics in treating dysbiotic-related conditions, possibly because they are derived directly from the host's own microbiota.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Celiberto LS,Pinto RA,Rossi EA,Vallance BA,Cavallini DCUdoi
10.3390/nu10111684subject
Has Abstractpub_date
2018-11-05 00:00:00issue
11issn
2072-6643pii
nu10111684journal_volume
10pub_type
杂志文章相关文献
Nutrients文献大全abstract::This paper continues the systematic review on proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontal disease and covers the immunomodulatory effects, and animal- and clinical studies, while the other part discussed the direct antibacterial properties. Inflammation as a major response of the ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu13010239
更新日期:2021-01-15 00:00:00
abstract::It is widely recognized that the intestinal microbiota plays a role in the initiation and perpetuation of intestinal inflammation in numerous chronic conditions. Most studies report intestinal dysbiosis in celiac disease (CD) patients, untreated and treated with a gluten-free diet (GFD), compared to healthy controls. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7085314
更新日期:2015-08-17 00:00:00
abstract::Lower vitamin D status at birth and during infancy has been associated with increased incidence of eczema and food allergies. The aim of this study was to investigate the effect of early infancy vitamin D supplementation on allergic disease outcomes in infants at "hereditary risk" of allergic disease, but who had suff...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061747
更新日期:2020-06-11 00:00:00
abstract::A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8090577
更新日期:2016-09-20 00:00:00
abstract::Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5125114
更新日期:2013-12-16 00:00:00
abstract::The effectiveness of biofeedback and neurofeedback has been investigated in a range of psychiatric disorders. However, to date, there are few studies on the clinical usefulness of feedback-based techniques for eating disorders (EDs) and EDs-related symptoms (e.g., food craving). A systematic search of PubMed, Scopus a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111806
更新日期:2018-11-20 00:00:00
abstract::Hypertension and arterial stiffening are independent predictors of cardiovascular mortality. Flavonoids may exert some vascular protection. We investigated the effects of black tea on blood pressure (BP) and wave reflections before and after fat load in hypertensives. According to a randomized, double-blind, controlle...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7021037
更新日期:2015-02-04 00:00:00
abstract::Fruit and vegetables (F&V) are imperative for good health, yet less than one per cent of Australian children consume these food groups in sufficient quantities. As guided by Social Cognitive Theory (SCT), this paper aimed to: (i) understand key informant perspectives of the amount, types and quality of F&V consumed by...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111603
更新日期:2018-11-01 00:00:00
abstract::Poor food literacy behaviours may contribute to food insecurity in developed countries. The aim of this research was to describe the apparent prevalence of food insecurity in adults at enrolment in a food literacy program and to examine the relationship between food insecurity and a range of independent variables. Ind...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020445
更新日期:2019-02-20 00:00:00
abstract::Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on di...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113297
更新日期:2020-10-28 00:00:00
abstract::Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural compone...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040769
更新日期:2019-04-02 00:00:00
abstract::Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates cholesterol, triglyceride and phospholipid metabolism in the blood and the brain. APOE gene regulates the expression of this protein and has three different alleles: ε2, ε3 and ε4. Carrying an APOE4 allele is recognised...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6104452
更新日期:2014-10-20 00:00:00
abstract::In this report, we present a detailed comparison of the lipid composition of human milk (HM) and formula milk (FM) targeting different lactation stages and infant age range. We studied HM samples collected from 26 Polish mothers from colostrum to 19 months of lactation, along with FM from seven brands available on the...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072165
更新日期:2020-07-21 00:00:00
abstract::Arterial hypertension is strongly related to overweight and obesity. In obese subjects, several mechanisms may lead to hypertension such as insulin and leptin resistance, perivascular adipose tissue dysfunction, renal impairment, renin-angiotensin-aldosterone-system activation and sympathetic nervous system activity. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11071667
更新日期:2019-07-21 00:00:00
abstract::The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-r...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051000
更新日期:2019-05-01 00:00:00
abstract::Botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. The extract of the Apocynum venetum leaves (AVLE), also known as Luobuma, exerts its antihypertensive effect via dilating the blood vessels in an endothelium- and concentration-depe...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075220
更新日期:2015-06-30 00:00:00
abstract::Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu2050532
更新日期:2010-05-01 00:00:00
abstract::Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumptio...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9050521
更新日期:2017-05-19 00:00:00
abstract::Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8050291
更新日期:2016-05-13 00:00:00
abstract::Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strate...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092525
更新日期:2020-08-20 00:00:00
abstract::The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112676
更新日期:2019-11-05 00:00:00
abstract::Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7125497
更新日期:2015-11-27 00:00:00
abstract::Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7115458
更新日期:2015-11-06 00:00:00
abstract::Background: Zanthoxylumarmatum DC. (ZA) is a traditional Asian culinary spice and medicinal compound, which is rich in monoterpenes and hydroxy α-sanshool. Mechanistic interactions with the monoamine, cholinergic and cannabinoid neurotransmission systems, as well as transient receptor potential (TRP) and potassium ion...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11123022
更新日期:2019-12-10 00:00:00
abstract::The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. Several studies have addressed lactic fermentation plus addition of e...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7042134
更新日期:2015-03-25 00:00:00
abstract::The development of certain chronic metabolic diseases has been attributed to elevated levels of dietary cholesterol. However, decades of research in animal models and humans have demonstrated a high complexity with respect to the impact of dietary cholesterol on the progression of these diseases. Thus, recent investig...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10070939
更新日期:2018-07-21 00:00:00
abstract:BACKGROUND:Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. METHODS:Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6-7 years in 2005, who were taking part in the International Study on Asthma and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075098
更新日期:2015-06-25 00:00:00
abstract::Dietary restraint is a commonly reported practice observed among young females. The practice remains controversial and can be interpreted as a beneficial self-regulating behavior or the opposite, an eating disorder that may have a detrimental effect on health. The aim of this short report was to investigate if dietary...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8120796
更新日期:2016-12-19 00:00:00
abstract::Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10010043
更新日期:2018-01-05 00:00:00
abstract::This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) rat model caused by chronic consumption of 30% sucrose in drinking water. A total of 70 male Wistar rats were divided into two groups: C and MS. Each of the...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071529
更新日期:2019-07-05 00:00:00