Abstract：
:Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Zile MHdoi
10.3390/nu2050532subject
Has Abstractpub_date
2010-05-01 00:00:00pages
532-50issue
5issn
2072-6643pii
nu2050532journal_volume
2pub_type
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