Abstract：
:Advanced glycation end products (AGEs) play a causative role in the development of diabetic nephropathy via induction of matrix protein deposition in kidneys. This study investigated inhibitory effects of chrysin, present in bee propolis and herbs, on glomerulosclerosis in db/db mice and AGEs-exposed renal mesangial cells. The in vivo study explored the demoting effects of 10 mg/kg chrysin on glomerular fibrosis in a type 2 diabetic model. Oral supplementation of chrysin inhibited the collagen fiber accumulation and α-smooth muscle actin (α-SMA) induction in periodic acid schiff-positive renal tissues of db/db mice. Moreover, treating db/db mice with chrysin diminished the level of AGEs increased in diabetic glomeruli. The in vitro study employed human mesangial cells exposed to 100 μg/mL AGE-BSA for 72 h in the presence of 1⁻20 μM chrysin. Glucose increased mesangial AGE production via induction of receptor for AGEs. Chrysin suppressed the induction of collagens, α-SMA, fibroblast-specific protein-1 and matrix metalloproteinases enhanced by AGE-bovine serum albumin. Furthermore, chrysin blunted transforming growth factor-β1 induction and Smad 2/3 activation in AGEs-exposed mesangial cells. These results demonstrate that chrysin attenuated accumulation of myofibroblast-like cells and matrix proteins in AGEs-laden diabetic glomeruli. Therefore, chrysin may be a potential renoprotective agent targeting glucose-mediated AGEs-associated glomerulosclerosis and fibrosis.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Lee EJ,Kang MK,Kim DY,Kim YH,Oh H,Kang YHdoi
10.3390/nu10070882subject
Has Abstractpub_date
2018-07-09 00:00:00issue
7issn
2072-6643pii
nu10070882journal_volume
10pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Malnutrition is highly prevalent in people with head and neck cancer (HCN) and is associated with poorer outcomes. However, variation in malnutrition diagnostic criteria has made translation of the most effective interventions into practice challenging. This study aimed to determine the prevalence of malnutrition in a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113493
更新日期：2020-11-13 00:00:00
abstract：:Beta-cryptoxanthin (β-cry) is a typical carotenoid found abundantly in fruit and vegetables such as the Japanese mandarin orange, persimmon, papaya, paprika, and carrot, and exerts various biological activities (e.g., antioxidant effects). We previously reported that β-cry suppressed lipopolysaccharide (LPS)-induced o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020368
更新日期：2019-02-10 00:00:00
abstract：:Most clinicians and health professionals have heard or read about metabolic syndrome [...]. ...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu12113501
更新日期：2020-11-14 00:00:00
abstract：:Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts as an antioxidant, and has neuroprotective properties. Consumption o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040936
更新日期：2019-04-25 00:00:00
abstract：:Human milk is the ideal nutrition source for healthy infants during the first six months of life and a detailed characterisation of the composition of milk from mothers that deliver prematurely (<37 weeks gestation), and of how human milk changes during lactation, would benefit our understanding of the nutritional req...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8050304
更新日期：2016-05-19 00:00:00
abstract：:Micronutrient Powder (MNP) is beneficial to control anemia, but some iron-related side-effects are common. A high level of iron in the groundwater used for drinking may exacerbate the side-effects among MNP users. We conducted a randomized controlled trial examining the effect of a low-dose iron MNP compared with the ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11112756
更新日期：2019-11-13 00:00:00
abstract：:Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. The aim of this study was to explore how these proteins enter saliva and their r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123838
更新日期：2020-12-16 00:00:00
abstract：:Hypertension and arterial stiffening are independent predictors of cardiovascular mortality. Flavonoids may exert some vascular protection. We investigated the effects of black tea on blood pressure (BP) and wave reflections before and after fat load in hypertensives. According to a randomized, double-blind, controlle...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7021037
更新日期：2015-02-04 00:00:00
abstract：:As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans,...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu2121297
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:A meta-analysis was conducted to summarize the evidence from prospective cohort and case-control studies regarding the association between coffee intake and biliary tract cancer (BTC) and liver cancer risk. METHODS:Eligible studies were identified by searches of PubMed and EMBASE databases from the earliest...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9090950
更新日期：2017-08-28 00:00:00
abstract：:Recent advances have indicated that osteocalcin, and in particular its undercarboxylated form (ucOC), is not only a nutritional biomarker reflective of vitamin K status and an indicator of bone health but also an active hormone that mediates glucose metabolism in experimental studies. This work has been supported by t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10070847
更新日期：2018-06-29 00:00:00
abstract：:Previous studies demonstrated effects of green tea on weight loss; however, green tea-induced modulation of adipocyte function is not fully understood. Here, we investigated effects of the major green tea phytochemical, epigallocatechin-3-gallate (EGCG) on triglyceride contents, lipolysis, mitochondrial function, and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9070680
更新日期：2017-06-30 00:00:00
abstract：:Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid co...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10081079
更新日期：2018-08-13 00:00:00
abstract：:Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal b...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10111746
更新日期：2018-11-13 00:00:00
abstract：:A dynamic human gastrointestinal (GI) model was used to digest cooked tubers from purple-fleshed Amachi and Leona potato cultivars to study anthocyanin biotransformation in the stomach, small intestine and colonic vessels. Colonic Caco-2 cancer cells and non-tumorigenic colonic CCD-112CoN cells were tested for cytotox...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu9090953
更新日期：2017-08-29 00:00:00
abstract：:Accumulated evidence suggests that the cruciferous vegetables-derived compound indole-3-carbinol (I3C) may protect against prostate cancer, but the precise mechanisms underlying its action remain unclear. This study aimed to verify the hypothesis that the beneficial effect of dietary I3C may be due to its modulatory e...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020467
更新日期：2019-02-22 00:00:00
abstract：:Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. OBJECTIVE:To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). DESIGN:Gut microbiot...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020278
更新日期：2020-01-21 00:00:00
abstract：:Chronic low-grade inflammation is a primary characteristic of obesity and can lead to other metabolic complications including insulin resistance and type 2 diabetes (T2D). Several anti-inflammatory dietary bioactives decrease inflammation that accompanies metabolic diseases. We are specifically interested in delta-toc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113356
更新日期：2020-10-30 00:00:00
abstract：:Adequate calorie restriction (CR) as a healthy lifestyle is recommended not only for people with metabolic disorders but also for healthy adults. Previous studies have mainly focused on the beneficial metabolic effects of CR on obese subjects, while its effects on non-obese subjects are still scarce. Here, we conducte...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu12030631
更新日期：2020-02-27 00:00:00
abstract：:Low temperature long time (LTLT) sous-vide cooking may modify meat proteins in a way that could promote satiety. We investigated the effects of (1) cooking method (LTLT 58 °C vs. oven 160 °C), (2) LTLT holding time (17 h vs. 72 min), and (3) pork structure, LTLT 58 °C for 17 h (minced vs. roast) on appetite regulation...
journal_title：Nutrients
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3390/nu9090941
更新日期：2017-08-26 00:00:00
abstract：:Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of the survival motor neuron protein (SMN) re...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123842
更新日期：2020-12-16 00:00:00
abstract：OBJECTIVE:(i) To analyze the eating behaviors and body satisfaction of boys and girls and to examine their mothers' perceptions of these two domains; and (ii) to evaluate eating problem predictors using child body mass index (BMI), self-esteem, and body satisfaction as well as maternal BMI, eating problems, and satisfa...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4040273
更新日期：2012-04-01 00:00:00
abstract：:Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Coch...
journal_title：Nutrients
pub_type： 杂志文章,meta分析,评审
doi：10.3390/nu8120789
更新日期：2016-12-03 00:00:00
abstract：:Diet and nutrition may be important modifiable risk factors for the development, progression and management of obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). This review examines the relationship between dietary patterns, nutrient intake and weight status in obstructive lung...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7031618
更新日期：2015-03-05 00:00:00
abstract：:Gluten cross-contamination in gluten-free food may jeopardize treatment of celiac patients. Considering the deficit of appropriate instruments to enable the implementation of safe production practices for gluten-free food, this study aimed to evaluate the application of a check-list elaborated for gluten cross-contami...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091274
更新日期：2018-09-10 00:00:00
abstract：:It has been reported that maternal nutrition determines the offspring's susceptibility to chronic diseases including cancer. Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring. Dams were fed a casein (CAS) diet...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020571
更新日期：2020-02-22 00:00:00
abstract：BACKGROUND:Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS:We enrolled 174 patients aged 65 years ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020224
更新日期：2019-01-22 00:00:00
abstract：:The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as well as environmental factors, particularly diet, t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092216
更新日期：2019-09-13 00:00:00
abstract：:Plant-based diets are associated with reduced risks of various chronic diseases in the general population. However, it is unclear how these benefits translate to Blacks living in the United States, who are disproportionately burdened with heart disease, cancer, diabetes, obesity, and chronic kidney disease. The object...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11122915
更新日期：2019-12-02 00:00:00
abstract：:This study aimed to investigate the effect of a high-protein diet on growth, body composition, and protein nutritional status of young rats. Newly-weaned Wistar rats, weighing 45-50 g, were distributed in two experimental groups, according to their diets, which contained 12% (G12) or 26% protein (G26), over a period o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4091328
更新日期：2012-09-01 00:00:00
