Abstract:
:Accumulated evidence suggests that the cruciferous vegetables-derived compound indole-3-carbinol (I3C) may protect against prostate cancer, but the precise mechanisms underlying its action remain unclear. This study aimed to verify the hypothesis that the beneficial effect of dietary I3C may be due to its modulatory effect on the gut microbiome of mice. Athymic nude mice (5⁻7 weeks old, male, Balb c/c nu/nu) with established tumor xenografts were fed a basal diet (AIN-93) with or without 1 µmoles I3C/g for 9 weeks. The effects of dietary I3C on gut microbial composition and microbial species interactions were then examined by 16s rRNA gene-based sequencing and co-occurrence network analysis. I3C supplementation significantly inhibited tumor growth (p < 0.0001) and altered the structure of gut microbiome. The abundance of the phylum Deferribacteres, more specifically, Mucispirillum schaedleri, was significantly increased by dietary I3C. Additionally, I3C consumption also changed gut microbial co-occurrence patterns. One of the network modules in the control group, consisting of seven bacteria in family S-27, was positively correlated with tumor size (p < 0.009). Moreover, dietary I3C disrupted microbial interactions and altered this association between specific microbial network and tumor development. Our results unraveled complex relationships among I3C ingestion, gut microbiota, and prostate tumor development and may provide a novel insight into the mechanism for the chemopreventive effect of dietary I3C on prostate cancer.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Wu Y,Li RW,Huang H,Fletcher A,Yu L,Pham Q,Yu L,He Q,Wang TTYdoi
10.3390/nu11020467subject
Has Abstractpub_date
2019-02-22 00:00:00issue
2issn
2072-6643pii
nu11020467journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract::Historically, Mangifera indica L. cultivations have been widely planted in tropical areas of India, Africa, Asia, and Central America. However, at least 20 years ago its spreading allowed the development of some cultivars in Sicily, an island to the south of Italy, where the favourable subtropical climate and adapted ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9050525
更新日期:2017-05-20 00:00:00
abstract::Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5125114
更新日期:2013-12-16 00:00:00
abstract::The etiology of inflammatory bowel disease (IBD) is complex but is thought to be linked to an intricate interaction between the host's immune system, resident gut microbiome and environment, i.e., diet. One dietary component that has a major impact on IBD risk and disease management is fiber. Fiber intakes in pediatri...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12103204
更新日期:2020-10-20 00:00:00
abstract::microRNAs (miRNAs), a class of small RNAs, are important regulators of various developmental processes in both plants and animals. Several years ago, a report showed the detection of diet-derived plant miRNAs in mammalian tissues and their regulation of mammalian genes, challenging the traditional functions of plant m...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7053184
更新日期:2015-04-30 00:00:00
abstract::G protein-coupled receptor 43/free fatty acid receptor 2 (GPR43/FFAR2) is essential for polymorphonuclear (PMN) recruitment. We investigated the expression of GPR43/FFAR2 in the colon from Crohn's disease patients and whether dietary fiber in enteral nutrition increases GPR43+ polymorphonuclear infiltration in mucosa....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075223
更新日期:2015-07-01 00:00:00
abstract::This secondary analysis study addressed a gap of knowledge: whether perceived stress reduction created by a lifestyle intervention might serve as a mediator for reducing fat and fast food intakes in low-income overweight or obese mothers of young children. This analysis included 338 low-income overweight or obese moth...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123606
更新日期:2020-11-24 00:00:00
abstract::Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variab...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020298
更新日期:2019-01-30 00:00:00
abstract::The association between breakfast quality and total diet quality of children and adolescents ((1-17.9 years (n = 1570)) from the National Dietary Survey on the Child and Adolescent Population in Spain (ENALIA) was analyzed. Dietary information was collected using two non-consecutive one-day food diaries (1-10 years ol...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123772
更新日期:2020-12-08 00:00:00
abstract::Children born from mothers with gestational diabetes mellitus (GDM) are at high-risk of obesity and type 2 diabetes. To date, there is a lack of effective strategies to prevent these complications. The aim of this study was to evaluate the association between diet quality and anthropometric and glycemic profiles of ch...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030570
更新日期:2019-03-07 00:00:00
abstract::Vitamin D and calcium supplementation have been posited to improve body composition and different formulations of calcium may impact bioavailability. However, data are lacking regarding the combinatorial effects of exercise, diet, and calcium and/or vitamin D supplementation on body composition changes in post-menopau...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030713
更新日期:2020-03-07 00:00:00
abstract:BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071555
更新日期:2019-07-10 00:00:00
abstract::Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in h...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5082924
更新日期:2013-07-29 00:00:00
abstract::Malnutrition is very prevalent in geriatric patients with hip fracture. Nevertheless, its importance is not fully recognized. The objective of this paper is to review the impact of malnutrition and of nutritional treatment upon outcomes and mortality in older people with hip fracture. We searched the PubMed database f...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10050555
更新日期:2018-04-30 00:00:00
abstract::This study investigated effects of patchouli essential oil (PEO) inhalation on metabolic parameters. First, to characterize aromatic compounds in PEO, solid-phase microextraction-gas chromatography/mass spectrometric detection was employed in which 19 aromatic compounds were identified. In GC-olfactometry analysis, li...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072077
更新日期:2020-07-13 00:00:00
abstract::Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10081063
更新日期:2018-08-10 00:00:00
abstract::Human milk (HM) influences infant feeding patterns and body composition (BC). This small proof-of concept longitudinal study investigated relationships between infant/maternal BC and HM casein, whey and total protein during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured at 2 (n = 15)...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091332
更新日期:2018-09-19 00:00:00
abstract::Nutritional supplements which include natural antitumoral compounds could represent safe and efficient additives for cancer patients. One such nutritional supplement, Ocoxin Oral solution (OOS), is a composite formulation that contains several antioxidants and exhibits antitumoral properties in several in vitro and in...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051068
更新日期:2019-05-14 00:00:00
abstract::Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunct...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10081120
更新日期:2018-08-18 00:00:00
abstract::Understanding the regulation of gene activities depending on DNA methylation has been the subject of much recent study. However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain. The aim of...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6062387
更新日期:2014-06-23 00:00:00
abstract::Emerging laboratory and animal studies indicate that green tea inhibits development and progression of pancreatic cancer, but evidence from epidemiologic studies appears inconsistent and inconclusive. A meta-analysis summarizing published case-control and cohort studies was performed to evaluate the association of gre...
journal_title:Nutrients
pub_type: 杂志文章,meta分析
doi:10.3390/nu6114640
更新日期:2014-10-28 00:00:00
abstract::In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13020292
更新日期:2021-01-20 00:00:00
abstract::The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concent...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8110696
更新日期:2016-11-04 00:00:00
abstract::Little is known about iodine nutritional status in island countries in the Pacific Ocean. The primary objective of this study was to report for the first time the iodine nutritional status of people in Nauru. In addition, sources of iodine nutrition (i.e., water and salt) were investigated. A school-based cross-sectio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8090520
更新日期:2016-08-23 00:00:00
abstract::Prenatal iron and folic acid (IFA) supplements are offered free to all pregnant women in Malawi to reduce maternal anemia and improve birth outcomes. We investigated the association between self-reported compliance to IFA intake and risk of low birth weight (LBW). Pregnant women who attended Bwaila Maternity Wing of L...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091275
更新日期:2018-09-10 00:00:00
abstract::The Editorial Office of Nutrients would like to report an error in the published paper [1] [...]. ...
journal_title:Nutrients
pub_type: 杂志文章,已发布勘误
doi:10.3390/nu10040467
更新日期:2018-04-10 00:00:00
abstract::Immigrants in the U.S. may encounter challenges of acculturation, including dietary habits, as they adapt to new surroundings. We examined Vietnamese and Hispanic immigrant children's American food consumption patterns in a convenience sample of 63 Vietnamese and Hispanic children in grades four to six who were attend...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9050460
更新日期:2017-05-05 00:00:00
abstract::Differences in postprandial insulin, glucose, and/or free fatty acid concentrations, following the consumption of breakfast, have been demonstrated to be dependent on habitual breakfast patterns. This study examined the effects of habitual breakfast patterns on postprandial appetite, satiety, and hormonal responses al...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11061223
更新日期:2019-05-29 00:00:00
abstract::Dietary and plasma total cysteine (tCys) have been associated with adiposity, possibly through interaction with stearoyl⁻CoA desaturase (SCD), which is an enzyme that is involved in fatty acid and energy metabolism. We evaluated the effect of a dietary intervention with low cysteine and methionine and high polyunsatur...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10121822
更新日期:2018-11-23 00:00:00
abstract::The assessment of diets in multi-ethnic cosmopolitan settings is challenging. A semi-quantitative 163-item food frequency questionnaire (FFQ) was developed for the adult Singapore population, and this study aimed to assess its reproducibility and relative validity against 24-h dietary recalls (24 h DR) and biomarkers....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101059
更新日期:2017-09-25 00:00:00
abstract::The objective was to determine effects of feed restriction and refeeding on reproductive development and energy balance in pre-pubertal male rats. Sprague Dawley rats (n = 32, 24 days old, ~65 g), were randomly allocated into four treatments (n = 8/treatment): (1) Control (CON, ad libitum feed; (2) Mild Restriction (M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091993
更新日期:2019-08-23 00:00:00