Abstract：
:microRNAs (miRNAs), a class of small RNAs, are important regulators of various developmental processes in both plants and animals. Several years ago, a report showed the detection of diet-derived plant miRNAs in mammalian tissues and their regulation of mammalian genes, challenging the traditional functions of plant miRNAs. Subsequently, multiple efforts have attempted to replicate these findings, with the results arguing against the uptake of plant dietary miRNAs in healthy consumers. Moreover, several reports suggest the potential for "false positive" detection of plant miRNAs in human tissues. Meanwhile, some research continues to suggest both the presence and function of dietary miRNAs in mammalian tissues. Here we review the recent literature and discuss the strengths and weaknesses of emerging work that suggests the feasibility of dietary delivery of miRNAs. We also discuss future experimental approaches to address this controversial topic.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Yang J,Hirschi KD,Farmer LMdoi
10.3390/nu7053184subject
Has Abstractpub_date
2015-04-30 00:00:00pages
3184-99issue
5issn
2072-6643pii
nu7053184journal_volume
7pub_type
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