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Vitamin K and Osteoporosis.

Abstract：

:Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts relevant effects on bone and the vascular system. In this review, we point out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated (active form) vitamin K dependent proteins (such as Osteocalcin and matrix Gla protein) to prevent bone health. Another bone-related action of Vitamin K is being a ligand of the nuclear steroid and xenobiotic receptor (SXR). We also discuss the recommended intake, deficiency, and assessment of vitamin K. Furthermore, we review the few available studies that have as pre-specified outcome bone fractures, indicating that we need more clinical studies to confirm that vitamin K is a potential therapeutic agent for bone fractures.

journal_name

Nutrients

journal_title

Nutrients

authors

Fusaro M,Cianciolo G,Brandi ML,Ferrari S,Nickolas TL,Tripepi G,Plebani M,Zaninotto M,Iervasi G,La Manna G,Gallieni M,Vettor R,Aghi A,Gasperoni L,Giannini S,Sella S,M Cheung A

doi

10.3390/nu12123625

subject

Has Abstract

pub_date

2020-11-25 00:00:00

issue

12

issn

2072-6643

pii

nu12123625

journal_volume

12

pub_type

杂志文章,评审

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