Abstract:
:Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through carbohydrate (mainly starch) degradation. The role of these CNVs in obesity has been scarcely explored in the Latino population, and thus the aim of our study was to evaluate the association of 1p31.1, 10q11.22, 11q11, 16p12.3 and 1p21.1 CNVs with obesity in 921 Mexican children, to replicate significant associations in 920 Mexican adults, and to analyze the association of AMY1 copy number with gut microbiota in 75 children and 45 adults. Of the five CNVs analyzed, 1q11 CNV was significantly associated with obesity in children, but not in adults. Only AMY1 CNV was significantly associated with obesity in both age groups. Moreover, gut microbiota analyses revealed a positive correlation between AMY1 copy number and Prevotella abundance. This genus has enzymes and gene clusters essential for complex polysaccharide degradation and utilization. To our knowledge, this is the first study to analyze the association of these five CNVs in the Mexican population and to report a correlation between AMY1 CN and gut microbiota in humans.
journal_name
Nutrientsjournal_title
Nutrientsauthors
León-Mimila P,Villamil-Ramírez H,López-Contreras BE,Morán-Ramos S,Macias-Kauffer LR,Acuña-Alonzo V,Del Río-Navarro BE,Salmerón J,Velazquez-Cruz R,Villarreal-Molina T,Aguilar-Salinas CA,Canizales-Quinteros Sdoi
10.3390/nu10111607subject
Has Abstractpub_date
2018-11-01 00:00:00issue
11issn
2072-6643pii
nu10111607journal_volume
10pub_type
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