Effect of the novel polysaccharide PolyGlycopleX® on short-chain fatty acid production in a computer-controlled in vitro model of the human large intestine.


:Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in vitro system simulating the conditions in the proximal large intestine (TIM-2) was used. Sodium hydroxide (NaOH) consumption in the system was used as an indicator of fermentability and SCFA and branched chain fatty acids (BCFA) production was determined. NaOH consumption was significantly higher for Fructooligosaccharide (FOS) than PGX, which was higher than cellulose (p = 0.002). At 32, 48 and 72 h, acetate and butyrate production were higher for FOS and PGX versus cellulose. Propionate production was higher for PGX than cellulose at 32, 48, 56 and 72 h and higher than FOS at 72 h (p = 0.014). Total BCFA production was lower for FOS compared to cellulose, whereas production with PGX was lower than for cellulose at 72 h. In conclusion, PGX is fermented by the colonic microbiota which appeared to adapt to the substrate over time. The greater propionate production for PGX may explain part of the cholesterol-lowering properties of PGX seen in rodents and humans.






Reimer RA,Maathuis AJ,Venema K,Lyon MR,Gahler RJ,Wood S




Has Abstract


2014-03-14 00:00:00












  • Is There Such a Thing as "Anti-Nutrients"? A Narrative Review of Perceived Problematic Plant Compounds.

    abstract::Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fal...


    pub_type: 杂志文章,评审


    authors: Petroski W,Minich DM

    更新日期:2020-09-24 00:00:00

  • Agricultural Food Production Diversity and Dietary Diversity among Female Small Holder Farmers in a Region of the Ecuadorian Andes Experiencing Nutrition Transition.

    abstract::Some rural areas of Ecuador, including the Imbabura Province of the Andes Highlands, are experiencing a double burden of malnutrition where micronutrient deficiencies persist at the same time obesity is increasing as many traditional home-grown foods are being replaced with more commercially prepared convenience foods...


    pub_type: 杂志文章


    authors: Melby CL,Orozco F,Averett J,Muñoz F,Romero MJ,Barahona A

    更新日期:2020-08-15 00:00:00

  • The Relationship between Social Capital within Its Different Contexts and Adherence to a Mediterranean Diet Among Lithuanian Adolescents.

    abstract::The eating habits of adolescents are a serious current public health problem. Scientists call attention to the availability of social resources for enhancing healthy eating behavior. Social capital defines those resources as trust, reciprocity, social participation, integrity, and coherence, and they are supposed to h...


    pub_type: 杂志文章


    authors: Mieziene B,Emeljanovas A,Novak D,Kawachi I

    更新日期:2019-06-14 00:00:00

  • Priority Actions to Advance Population Sodium Reduction.

    abstract::High sodium intake is estimated to cause approximately 3 million deaths per year worldwide. The estimated average sodium intake of 3.95 g/day far exceeds the recommended intake. Population sodium reduction should be a global priority, while simultaneously ensuring universal salt iodization. This article identifies hig...


    pub_type: 杂志文章,评审


    authors: Ide N,Ajenikoko A,Steele L,Cohn J,J Curtis C,Frieden TR,Cobb LK

    更新日期:2020-08-22 00:00:00

  • Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions.

    abstract::Accumulated evidence suggests that the cruciferous vegetables-derived compound indole-3-carbinol (I3C) may protect against prostate cancer, but the precise mechanisms underlying its action remain unclear. This study aimed to verify the hypothesis that the beneficial effect of dietary I3C may be due to its modulatory e...


    pub_type: 杂志文章


    authors: Wu Y,Li RW,Huang H,Fletcher A,Yu L,Pham Q,Yu L,He Q,Wang TTY

    更新日期:2019-02-22 00:00:00

  • Almonds and Cardiovascular Health: A Review.

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    pub_type: 杂志文章,评审


    authors: Kalita S,Khandelwal S,Madan J,Pandya H,Sesikeran B,Krishnaswamy K

    更新日期:2018-04-11 00:00:00

  • Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats.

    abstract::Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesi...


    pub_type: 杂志文章


    authors: Melo BF,Sacramento JF,Ribeiro MJ,Prego CS,Correia MC,Coelho JC,Cunha-Guimaraes JP,Rodrigues T,Martins IB,Guarino MP,Seiça RM,Matafome P,Conde SV

    更新日期:2019-05-28 00:00:00

  • Iron Absorption from Three Commercially Available Supplements in Gastrointestinal Cell Lines.

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    pub_type: 杂志文章


    authors: Uberti F,Morsanuto V,Ghirlanda S,Molinari C

    更新日期:2017-09-13 00:00:00

  • MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population.

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    pub_type: 杂志文章


    authors: Wu DF,Yin RX,Cao XL,Huang F,Wu JZ,Chen WX

    更新日期:2016-04-08 00:00:00

  • Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?

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    pub_type: 杂志文章,评审


    authors: Ratajczak AE,Szymczak-Tomczak A,Zawada A,Rychter AM,Dobrowolska A,Krela-Kaźmierczak I

    更新日期:2021-01-13 00:00:00

  • Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance.

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    pub_type: 杂志文章


    authors: Torres DJ,Pitts MW,Hashimoto AC,Berry MJ

    更新日期:2019-07-23 00:00:00

  • Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial.

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    pub_type: 杂志文章,随机对照试验


    authors: Freitas-Simoes TM,Cofán M,Blasco MA,Soberón N,Foronda M,Serra-Mir M,Roth I,Valls-Pedret C,Doménech M,Ponferrada-Ariza E,Calvo C,Rajaram S,Sabaté J,Ros E,Sala-Vila A

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  • Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress.

    abstract::The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the present study, we discovered that leucine-h...


    pub_type: 杂志文章


    authors: Ano Y,Kita M,Kitaoka S,Furuyashiki T

    更新日期:2019-09-09 00:00:00

  • Cultural Differences in Stress-Related Psychological, Nutrition, Physical Activity and Oral Health Factors of Professors.

    abstract::With the aim to explore cultural differences in stress-related psychological, nutrition, physical activity, and oral health factors between Spanish and Latin American professors, we analysed stress-related factors in 598 professors (39.9% male, 60.1% female, 41.3 ± 9.8 years) by a collection of questionnaires, which i...


    pub_type: 杂志文章


    authors: Redondo-Flórez L,Fernández-Lucas J,Clemente-Suárez VJ

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  • Beliefs about Binge Eating: Psychometric Properties of the Eating Beliefs Questionnaire (EBQ-18) in Eating Disorder, Obese, and Community Samples.

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    pub_type: 杂志文章


    authors: Burton AL,Mitchison D,Hay P,Donnelly B,Thornton C,Russell J,Swinbourne J,Basten C,Goldstein M,Touyz S,Abbott MJ

    更新日期:2018-09-14 00:00:00

  • The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions.

    abstract::This study aimed to investigate the beneficial effects of A. melanocarpa on testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) in Wistar rats. Moreover, the bioactive constituents in the extract were determined using LC/MS and HPLC analyses. The dried fruits of A. melanocarpa were extracted using ...


    pub_type: 杂志文章


    authors: Kim NH,Jegal J,Kim YN,Heo JD,Rho JR,Yang MH,Jeong EJ

    更新日期:2020-05-28 00:00:00

  • Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

    abstract::Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent ma...


    pub_type: 杂志文章,随机对照试验


    authors: Vossen LM,Schurgers LJ,van Varik BJ,Kietselaer BL,Vermeer C,Meeder JG,Rahel BM,van Cauteren YJ,Hoffland GA,Rennenberg RJ,Reesink KD,de Leeuw PW,Kroon AA

    更新日期:2015-10-28 00:00:00

  • Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners.

    abstract:BACKGROUND:Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway i...


    pub_type: 临床试验,杂志文章


    authors: Vaisberg M,Paixão V,Almeida EB,Santos JMB,Foster R,Rossi M,Pithon-Curi TC,Gorjão R,Momesso CM,Andrade MS,Araujo JR,Garcia MC,Cohen M,Perez EC,Santos-Dias A,Vieira RP,Bachi ALL

    更新日期:2019-07-22 00:00:00

  • Cutaneous and Mucosal Manifestations Associated with Celiac Disease.

    abstract::Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, ...


    pub_type: 杂志文章,评审


    authors: Rodrigo L,Beteta-Gorriti V,Alvarez N,Gómez de Castro C,de Dios A,Palacios L,Santos-Juanes J

    更新日期:2018-06-21 00:00:00

  • Proteomics Analysis Reveals the Implications of Cytoskeleton and Mitochondria in the Response of the Rat Brain to Starvation.

    abstract::Long-term starvation provokes a metabolic response in the brain to adapt to the lack of nutrient intake and to maintain the physiology of this organ. Here, we study the changes in the global proteomic profile of the rat brain after a seven-day period of food deprivation, to further our understanding of the biochemical...


    pub_type: 杂志文章


    authors: Cuevas-Fernández B,Fuentes-Almagro C,Peragón J

    更新日期:2019-01-22 00:00:00

  • Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.

    abstract::Coffee is a blend of compounds related to gastrointestinal physiology. Given its popularity and the epidemiology of colorectal cancer, the impact of this beverage on public health could be considerable. Our aim was to provide an updated synthesis of the relationship between coffee consumption and the risk of colorecta...


    pub_type: 杂志文章,meta分析


    authors: Sartini M,Bragazzi NL,Spagnolo AM,Schinca E,Ottria G,Dupont C,Cristina ML

    更新日期:2019-03-24 00:00:00

  • Effect of Defatted Dabai Pulp Extract in Urine Metabolomics of Hypercholesterolemic Rats.

    abstract::A source of functional food can be utilized from a source that might otherwise be considered waste. This study investigates the hypocholesterolemic effect of defatted dabai pulp (DDP) from supercritical carbon dioxide extraction and the metabolic alterations associated with the therapeutic effects of DDP using 1H NMR ...


    pub_type: 杂志文章


    authors: Kadir NAAA,Azlan A,Abas F,Ismail IS

    更新日期:2020-11-14 00:00:00

  • Phenethyl Isothiocyanate Protects against High Fat/Cholesterol Diet-Induced Obesity and Atherosclerosis in C57BL/6 Mice.

    abstract::This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mic...


    pub_type: 杂志文章


    authors: Gwon MH,Im YS,Seo AR,Kim KY,Moon HR,Yun JM

    更新日期:2020-11-27 00:00:00

  • Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes.

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    pub_type: 杂志文章,评审


    authors: Inoue T,Maeda K,Nagano A,Shimizu A,Ueshima J,Murotani K,Sato K,Tsubaki A

    更新日期:2020-12-04 00:00:00

  • Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus.

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    pub_type: 杂志文章,评审


    authors: de la Visitación N,Robles-Vera I,Toral M,Duarte J

    更新日期:2019-11-05 00:00:00

  • Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial.

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    pub_type: 杂志文章


    authors: Carroccio A,Mansueto P,Soresi M,Fayer F,Di Liberto D,Monguzzi E,Lo Pizzo M,La Blasca F,Geraci G,Pecoraro A,Dieli F,Schuppan D

    更新日期:2020-04-17 00:00:00

  • An Extract of Olive Mill Wastewater Downregulates Growth, Adhesion and Invasion Pathways in Lung Cancer Cells: Involvement of CXCR4.

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    pub_type: 杂志文章


    authors: Gallazzi M,Festa M,Corradino P,Sansone C,Albini A,Noonan DM

    更新日期:2020-03-26 00:00:00

  • Migration Rate Inhibition of Breast Cancer Cells Treated by Caffeic Acid and Caffeic Acid Phenethyl Ester: An In Vitro Comparison Study.

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    pub_type: 杂志文章


    authors: Kabała-Dzik A,Rzepecka-Stojko A,Kubina R,Jastrzębska-Stojko Ż,Stojko R,Wojtyczka RD,Stojko J

    更新日期:2017-10-19 00:00:00

  • Total Dietary Antioxidant Intake Including Polyphenol Content: Is it Capable to Fight against Increased Oxidants within the Body of Ultra-Endurance Athletes?

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    pub_type: 杂志文章


    authors: Devrim-Lanpir A,Bilgic P,Kocahan T,Deliceoğlu G,Rosemann T,Knechtle B

    更新日期:2020-06-23 00:00:00

  • Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs).

    abstract::Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations have shown that...


    pub_type: 杂志文章,评审


    authors: Jaafaru MS,Abd Karim NA,Enas ME,Rollin P,Mazzon E,Abdull Razis AF

    更新日期:2018-05-08 00:00:00