Abstract:
:Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Ratto D,Corana F,Mannucci B,Priori EC,Cobelli F,Roda E,Ferrari B,Occhinegro A,Di Iorio C,De Luca F,Cesaroni V,Girometta C,Bottone MG,Savino E,Kawagishi H,Rossi Pdoi
10.3390/nu11040715subject
Has Abstractpub_date
2019-03-27 00:00:00issue
4issn
2072-6643pii
nu11040715journal_volume
11pub_type
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