Abstract：
:Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Ratto D,Corana F,Mannucci B,Priori EC,Cobelli F,Roda E,Ferrari B,Occhinegro A,Di Iorio C,De Luca F,Cesaroni V,Girometta C,Bottone MG,Savino E,Kawagishi H,Rossi Pdoi
10.3390/nu11040715subject
Has Abstractpub_date
2019-03-27 00:00:00issue
4issn
2072-6643pii
nu11040715journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Neuroinflammation is pathological evidence of Alzheimer's disease (AD) that likely starts as a host defense response to the damaging effects of the β-amyloid (Aβ) deposits in the brain. The activation of microglia may promote the neurodegenerative process through the release of proinflammatory cytokines, such as inter...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010024
更新日期：2017-01-03 00:00:00
abstract：:The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051539
更新日期：2020-05-25 00:00:00
abstract：:Anemia and micronutrient deficiencies are widespread in sub-Saharan Africa, but the impact of food fortification is still debated. The objective of this study was to estimate the iron and vitamin A status of preschool children (PSC) and women of reproductive age (WRA) in households consuming fortified oil and wheat fl...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8030148
更新日期：2016-03-07 00:00:00
abstract：:In physiological conditions, the gut is heavily infiltrated with various subsets of inflammatory cells, whose activity is tightly controlled by counter-regulatory mechanisms. Defects in such mechanisms can favour the development of chronic intestinal disorders, such as Crohn's disease (CD) and ulcerative colitis (UC),...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102334
更新日期：2019-10-01 00:00:00
abstract：:Due to the functional properties and physiological effects often associated with chemically modified starches, significant interest lies in their development for incorporation in processed foods. This study investigated the effect of transglycosylated cornstarch (TGS) on blood glucose, insulin, and serum metabolome in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9030291
更新日期：2017-03-16 00:00:00
abstract：:A better understanding of vitamin K's role in health and disease requires the assessment of vitamin K nutritional status in population and clinical studies. This is primarily accomplished using dietary questionnaires and/or biomarkers. Because food composition databases in the US are most complete for phylloquinone (v...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8010008
更新日期：2016-01-02 00:00:00
abstract：:We evaluated the concordance between visceral fat area (VFA) estimated by bioelectrical impedance analysis (BIA) or computed tomography (CT) in Korean subjects with a wide range in age and body mass index (BMI). In 1006 individuals (mean age 55.2 ± 11.8 (19-87) years, mean BMI 26.0 ± 3.5 (17-46) kg/m², 48.9% men), VFA...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7125548
更新日期：2015-12-16 00:00:00
abstract：:The current performance indicator for universal salt iodisation (USI) is the percentage of households using adequately iodised salt. However, the proportion of dietary salt from household salt is decreasing with the increase in consumption of processed foods and condiments globally. This paper reports on case studies ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9080797
更新日期：2017-07-26 00:00:00
abstract：:Gluten cross-contamination in gluten-free food may jeopardize treatment of celiac patients. Considering the deficit of appropriate instruments to enable the implementation of safe production practices for gluten-free food, this study aimed to evaluate the application of a check-list elaborated for gluten cross-contami...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091274
更新日期：2018-09-10 00:00:00
abstract：:The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5030725
更新日期：2013-03-07 00:00:00
abstract：:Parents' stress is independently associated with increased child adiposity, but parents' stress may also interfere with childhood obesity prevention programs. The disruptions to the family dynamic caused by participating in a behaviour change intervention may exacerbate parent stress and undermine overall intervention...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061835
更新日期：2020-06-19 00:00:00
abstract：:Insufficient dietary intake, micronutrient deficiencies, and infection may result in malnutrition. In Zambia, an estimated 14% of women are vitamin A-deficient, ~50% are anemic, 10% are underweight, and 23% are overweight/obese. A cross-sectional survey determined food and nutrient intakes of randomly selected Zambian...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020288
更新日期：2019-01-29 00:00:00
abstract：:(1) Background: Psoriatic Arthritis (PsA) is a painful disease of the joints and spine. Recent reports observed distinct enteric dysbiosis in PsA; intake of probiotic strains is considered to ameliorate enteric dysbiosis. If probiotics are effective in PsA is elusive. (2) Methods: In this pilot open-label study we enr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082337
更新日期：2020-08-05 00:00:00
abstract：:Standardized sex-specific cut-offs for sarcopenia in cirrhosis are needed to identify the risk of clinical complications and to discriminate the severity of sarcopenia. We aimed to compare clinical characteristics between patients with cirrhosis categorized according to the severity of sarcopenia. Computed tomography ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113463
更新日期：2020-11-11 00:00:00
abstract：:We commend Adams et al [...]. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051126
更新日期：2019-05-21 00:00:00
abstract：:Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is as...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113528
更新日期：2020-11-17 00:00:00
abstract：:In children, functional gastrointestinal disorders (FGIDs) are common at all ages. Consumption of certain foods, particularly gluten, is frequently associated with the development and persistence of FGIDs and functional abdominal pain disorders (FAPDs) in adults and children. However, this association is not well defi...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10101491
更新日期：2018-10-12 00:00:00
abstract：:Poor diet quality and obesity, especially abdominal obesity, have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available and inexpensive inflammation biomarker. The aim of the present study was to determine the association of dietary patterns and obesity with an inflammato...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030855
更新日期：2020-03-23 00:00:00
abstract：:Folic acid (FA) intake has been associated with increased breast cancer risk in some studies. Although underlying mechanisms are unknown, epigenetic modifications that persistently alter transcription have been suggested. We tested the hypothesis that high FA (HFA) intake alters the adult mammary transcriptome in a ma...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092821
更新日期：2020-09-15 00:00:00
abstract：:The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise can attenuate the loss of muscle mass during severe energy deficit (5500 kcal/day). Overweight men...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11112824
更新日期：2019-11-19 00:00:00
abstract：:The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081836
更新日期：2019-08-08 00:00:00
abstract：:The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an adequ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12061718
更新日期：2020-06-08 00:00:00
abstract：BACKGROUND:In South Africa, the increased consumption of sugary drinks has been associated with increased obesity rates. Mass media campaigns can play a crucial role in improving knowledge, shifting attitudes, and building support for government action on reducing sugary drink consumption. No study to date has evaluate...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061878
更新日期：2020-06-23 00:00:00
abstract：:The lack of effective treatment for chronic discomfort without negative side effects highlights the need for alternative treatments. Pain Bloc-R is a natural health product composed of vitamins B6, B12, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061831
更新日期：2020-06-19 00:00:00
abstract：:This review discusses the personalised dietary approach with respect to inflammatory bowel disease (IBD). It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. It also discusses food intoler...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11071532
更新日期：2019-07-05 00:00:00
abstract：:The purpose of this study was to conduct a literature review to examine micronutrient deficiencies in laparoscopic sleeve gastrectomy. We conducted a literature review using PubMed and Cochrane databases to examine micronutrient deficiencies in SG patients in order to identify trends and find consistency in recommenda...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092896
更新日期：2020-09-22 00:00:00
abstract：:Children's eating behavior does not necessarily align with dietary recommendations, and there is a need for better understanding the factors underlying their food choices. The aim of this study was to investigate children's self-reported reasons for accepting and rejecting foods. A questionnaire was developed with rea...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102455
更新日期：2019-10-14 00:00:00
abstract：BACKGROUND:High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect of high protein diet (HPD) on the gut microbiome of obesity, but there are few studies in humans. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12103221
更新日期：2020-10-21 00:00:00
abstract：BACKGROUND:Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxici...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9060625
更新日期：2017-06-17 00:00:00
abstract：:A growing body of evidence supports a role for tissue-to-diet 15N and 13C discrimination factors (Δ15N and Δ13C), as biomarkers of metabolic adaptations to nutritional stress, but the underlying mechanisms remain poorly understood. In obese rats fed ad libitum or subjected to gradual caloric restriction (CR), under a ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051087
更新日期：2019-05-16 00:00:00
