Abstract:
:Hot water was used to obtain Chlorella sorokiniana hot water extract (HWE). Subsequently, this byproduct was freeze-dried, hydrolysed at 50 °C using Protease N to obtain C. sorokiniana protein hydrolysates (PN-1), and then digested with a gastrointestinal enzyme (PN-1G). The inhibitory effects of the HWE and hydrolysates against angiotensin I-converting enzyme (ACE) were investigated. The soluble protein and peptide contents were 379.9 and 179.7 mg/g, respectively, for HWE and 574.8 and 332.8 mg/g, respectively, for PN-1. The IC50 values of the HWE, PN-1, and PN-1G on ACE were 1.070, 0.035, and 0.044 mg/mL, respectively. PN-1G was separated into seven fractions through size exclusion chromatography. The sixth fraction of the hydrolysate had a molecular weight between 270 and 340 Da, and the lowest IC50 value on ACE was 0.015 mg/mL. The amino acid sequences of the ACE-inhibitory peptides were Trp-Val, Val-Trp, Ile-Trp, and Leu-Trp, of which the IC50 values were 307.61, 0.58, 0.50, and 1.11 µΜ, respectively. Systolic blood pressure and diastolic blood pressure were reduced 20 and 21 mm Hg, respectively, in spontaneously hypertensive rats after 6 h of oral administration with a dose of 171.4 mg PN-1 powder/kg body weight.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Lin YH,Chen GW,Yeh CH,Song H,Tsai JSdoi
10.3390/nu10101397subject
Has Abstractpub_date
2018-10-01 00:00:00issue
10issn
2072-6643pii
nu10101397journal_volume
10pub_type
杂志文章相关文献
Nutrients文献大全abstract::Systemic and localized ischemia and reperfusion injury remain clinically relevant issues after organ transplantation and contribute to organ dysfunctions, among which acute kidney injury is one of the most common. An in vitro test-circuit for normothermic perfusion of porcine kidneys after warm ischemia was used to in...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081774
更新日期:2019-08-01 00:00:00
abstract::Caffeine is the world's most commonly used stimulant of the central nervous system. Caffeine is present in coffee and other beverages such as tea, soft drinks, and cocoa-based foods. The caffeine expectancy questionnaire was developed to investigate the effects of caffeine expectations and thus contribute to knowledge...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082248
更新日期:2020-07-28 00:00:00
abstract::Our group built a genetic risk score (GRS) of the plasma triglyceride (TG) response to an omega-3 (n-3) fatty acid (FA) supplementation in Caucasian Canadians that explained 21.53% of the TG variance. The objective was to refine the GRS by fine mapping and to test its association with the TG response in young Mexican ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040737
更新日期:2019-03-29 00:00:00
abstract::To the best of our knowledge, no specific questionnaires on sports nutrition knowledge (NK) have been validated so far in Italian early adolescents. The aim of the present study was to validate a short (26-item) general and sports NK questionnaire in a group of Italian early adolescents. To this aim, the questionnaire...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12103121
更新日期:2020-10-13 00:00:00
abstract::Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12020284
更新日期:2020-01-21 00:00:00
abstract::Antimicrobial peptides (AMPs) are components of the innate immune system and form the first defense against pathogens for various organisms. In the present study, we assessed whether CSP32, a novel AMP oligomer of bacitracin isolated from a strain of Bacillus spp., regulates the polarization of murine macrophage-like ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061603
更新日期:2020-05-29 00:00:00
abstract::Over recent years, studies have demonstrated links between risk of cardiovascular disease in adulthood and adverse events that occurred very early in life during fetal development. The concept that there are embryonic and fetal adaptive responses to a sub-optimal intrauterine environment often brought about by poor ma...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7010119
更新日期:2014-12-29 00:00:00
abstract::Ingredients delivering functional and nutritional benefits are of interest to food manufacturers. Isomaltooligosaccharides (IMOs) which serve as alternate sweeteners fit into this category. IMOs are a mixture of α-(1 → 6) and α-(1 → 4)-linked glucose oligomers, synthesized by an enzymatic reaction from starch (corn, t...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10030301
更新日期:2018-03-03 00:00:00
abstract::The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 438...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122885
更新日期:2019-11-27 00:00:00
abstract::Enzyme treatment of the foods and herbs has been used to improve the absorption rate the efficiency of plant extracts by converting the glycosides of the plant into aglycones. In this study, we examined the obesity-inhibitory effect of Chrysanthemumindicum Linné (CI) treated with enzymes such as viscozyme and tannase,...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020269
更新日期:2019-01-25 00:00:00
abstract::This study evaluated the effect of linseed incorporation in laying hens' feed (alone or along with a tomato-red pepper mix) on laying hens' egg yolk fatty acids profile, as well as on their atherogenic (IA) and thrombogenic (IT) health lipid indexes, and the ratio between the hypocholesterolemic and hypercholesterolem...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040813
更新日期:2019-04-10 00:00:00
abstract::This study aimed to observe the relationship between iodine nutrition status (dietary iodine intake and estimated iodine intake based on urinary iodine concentration (UIC)) and thyroid disease-related hormones. This study involved 6090 subjects >19 years old with valid UIC, assessed between 2013 and 2015 by the Korean...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112757
更新日期:2019-11-13 00:00:00
abstract::We have identified a clinical association between self-reported non-celiac wheat sensitivity (NCWS) and Familial Mediterranean Fever (FMF). Objectives: A) To determine whether a 2-week double-blind placebo-controlled (DBPC) cross-over wheat vs. rice challenge exacerbates the clinical manifestations of FMF; B) to evalu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041127
更新日期:2020-04-17 00:00:00
abstract::We evaluated the concordance between visceral fat area (VFA) estimated by bioelectrical impedance analysis (BIA) or computed tomography (CT) in Korean subjects with a wide range in age and body mass index (BMI). In 1006 individuals (mean age 55.2 ± 11.8 (19-87) years, mean BMI 26.0 ± 3.5 (17-46) kg/m², 48.9% men), VFA...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7125548
更新日期:2015-12-16 00:00:00
abstract::Early identification of women at risk of developing pregnancy-induced hypertension (PIH) is very important. The involvement of copper (Cu) and zinc (Zn) in the oxidative balance suggests the possibility of their association with this disease, in which oxidative stress plays a key role. However, it has not been establi...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11102479
更新日期:2019-10-16 00:00:00
abstract:BACKGROUND:Oropharyngeal dysphagia (OD) and malnutrition are highly prevalent in older patients that are discharged from general hospitals (47% and 30%, respectively). AIMS:To develop a nutritional plan for these patients involving a triple adaptation of their traditional diet: (a) rheological adaptation (texture and ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020425
更新日期:2019-02-18 00:00:00
abstract::The association of socioeconomic status (SES) with nutrient intake attracts public attention worldwide. In the current study, we examined the associations of SES with dietary intake of folate and health outcomes in general Japanese workers. This Japanese occupational cohort consisted off 2266 workers. SES was assessed...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5020565
更新日期:2013-02-18 00:00:00
abstract::Dietary and plasma total cysteine (tCys) have been associated with adiposity, possibly through interaction with stearoyl⁻CoA desaturase (SCD), which is an enzyme that is involved in fatty acid and energy metabolism. We evaluated the effect of a dietary intervention with low cysteine and methionine and high polyunsatur...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10121822
更新日期:2018-11-23 00:00:00
abstract::Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five ob...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030580
更新日期:2019-03-08 00:00:00
abstract::Isoflavones are phenolic compounds with a chemical structure similar to that of estradiol. They are present in several vegetables, mainly in legumes such as soy, white and red clover, alfalfa and beans. The most significant food source of isoflavones in humans is soy-derived products. Isoflavones could be used as an a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123853
更新日期:2020-12-17 00:00:00
abstract::Obesity often has its onset in childhood and can be accompanied by various comorbidities such as functional gastrointestinal disorders and altered gastric myoelectrical activity (GMA). This study investigates whether obesity in childhood and adolescence is already associated with altered GMA, and whether an inpatient ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10060699
更新日期:2018-05-31 00:00:00
abstract::Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. T...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10020248
更新日期:2018-02-22 00:00:00
abstract::The Editorial Office of Nutrients would like to report an error in the published paper [1] [...]. ...
journal_title:Nutrients
pub_type: 杂志文章,已发布勘误
doi:10.3390/nu10040467
更新日期:2018-04-10 00:00:00
abstract::Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option fo...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11061307
更新日期:2019-06-10 00:00:00
abstract::Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040872
更新日期:2019-04-18 00:00:00
abstract::Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate an...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101555
更新日期:2018-10-20 00:00:00
abstract::Metabolic syndrome (MetS) is defined as a cluster of metabolic alterations such as abdominal obesity, dyslipidemias, elevated fasting glucose, and hypertension. Studies on the association between egg consumption and MetS are limited and inconsistent. A cross-sectional analysis was conducted to examine the association ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9070687
更新日期:2017-07-02 00:00:00
abstract::As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pat...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9020096
更新日期:2017-01-31 00:00:00
abstract::Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081790
更新日期:2019-08-02 00:00:00
abstract::As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans,...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu2121297
更新日期:2010-12-01 00:00:00