Abstract：
:Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five obese adults (Age: 52.4 ± 3.2 year, BMI: 32.5 ± 1.2 kg/m²) were screened for normal glucose tolerance (NGT, n = 8) and prediabetes (PD, n = 17) using American Diabetes Association criteria (75 g OGTT and/or HbA1c). Body composition (bioelectrical impedance) and fitness (VO₂peak) were measured. Arterial stiffness (augmentation index; AIx) was measured at 0, 60- and 120-min while insulin, glucose, and free fatty acids were evaluated every 30 min during the OGTT to assess CVD risk. Annexin V positive (AV+) and Annexin V negative (AV-) total EVs, platelet EVs (CD31⁺/CD41⁺; CD41⁺), leukocyte EVs (CD45⁺; CD45⁺/CD41-), platelet endothelial cell adhesion molecule (PECAM) (CD31⁺) and endothelial EVs (CD 31⁺/CD41-; CD105⁺) were collected at 0 and 120 min. There were no differences in age, BMI, or body fat between NGT and PD (all P > 0.63). Total EVs, AV+ CD31+ (PECAM), and AV+ CD31⁺/CD41- (endothelial) EVs decreased after the OGTT (P ≤ 0.04). Circulating insulin at 2-h correlated with elevated post-prandial AV- CD45⁺ (r = 0.48, P = 0.04) while arterial stiffness related to reduced total EVs (r = -0.49, P = 0.03) and AV+CD41⁺ (platelet) (r = -0.52, P = 0.02). An oral glucose load lowers post-prandial total, platelet, and endothelial EVs in obese adults with NGT and prediabetes in relation to CVD risk.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Eichner NZM,Gilbertson NM,Musante L,La Salvia S,Weltman A,Erdbrügger U,Malin SKdoi
10.3390/nu11030580subject
Has Abstractpub_date
2019-03-08 00:00:00issue
3issn
2072-6643pii
nu11030580journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:The impact of pre-pregnancy obesity and maternal diet quality on the use of healthcare resources during the perinatal period is underexplored. We assessed the effects of body mass index (BMI) and diet quality on the use of healthcare resources, to identify whether maternal diet quality may be effectively targeted to r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113532
更新日期：2020-11-17 00:00:00
abstract：:Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and b...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11081736
更新日期：2019-07-26 00:00:00
abstract：AIM:To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN). PATIENTS-METHODS:In this prospective, double-blind, placebo-controlled study, 85 patients with Diabetes Mellitus Type 2 (DMT2) were randomly assigned, either ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113254
更新日期：2020-10-23 00:00:00
abstract：:Postprandial hyperglycemia interferes with vascular reactivity and is a strong predictor of cardiovascular disease. Macronutrient preloads reduce postprandial hyperglycemia in subjects with impaired glucose tolerance (IGT) or type 2 diabetes (T2D), but the effect on endothelial function is unknown. Therefore, we exami...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072053
更新日期：2020-07-10 00:00:00
abstract：:Several theories have emerged to study types of eating behavior leading to obesity, but most of the applied models are mainly related to food choice decisions and food consumer behavior. The purpose of this paper was to examine the eating attitudes of Hungarian consumers by applying the Three-Factor Eating Questionnai...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113514
更新日期：2020-11-15 00:00:00
abstract：:Aim: The objective of this study was to characterize the early effects of high fructose diets (with and without high fat) on both the composition of the gut microbiota and lipid metabolism in Syrian hamsters, a reproducible preclinical model of diet-induced dyslipidemia. Methods: Eight-week-old male hamsters were fed ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113557
更新日期：2020-11-20 00:00:00
abstract：:Gluten-free diets are increasingly chosen in the Western world, even in the absence of a diagnosis of celiac disease. Around 10% of people worldwide self-report gluten-related complaints, including intestinal and extra-intestinal symptoms. In most cases, these subjects would be labeled as patients suffering from irrit...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123735
更新日期：2020-12-04 00:00:00
abstract：:Drug resistance is a major problem in the treatment of non-small-cell lung cancer (NSCLC). In this study, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to identify the differentially expressed genes in Adriamycin (ADR)-resistant NSCLC A549/ADR cells compared with parental A549 cells. Am...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10121829
更新日期：2018-11-26 00:00:00
abstract：:The composition and functioning of the gut microbiota, the complex population of microorganisms residing in the intestine, is strongly affected by endogenous and exogenous factors, among which diet is key. Important perturbations of the microbiota have been observed to contribute to disease risk, as in the case of neu...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12113319
更新日期：2020-10-29 00:00:00
abstract：:Previous studies demonstrated that hyperglycemic glucose concentrations are observed in children that are overweight or have obesity. The aim of this study was to evaluate the effect of a 12 month lifestyle intervention on free-living glycemic profiles in children that were overweight or had obesity, and the associati...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051228
更新日期：2020-04-26 00:00:00
abstract：:The dietary fiber gap that is present in many countries co-exists with a low intake of grain legumes (pulses) that have 2-3 times more dietary fiber than cereal grains that are commonly recommended to increase fiber intake. Given the relationships among dietary fiber, gut health and chronic disease risk, a study was u...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030593
更新日期：2020-02-25 00:00:00
abstract：:Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a ro...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11061273
更新日期：2019-06-05 00:00:00
abstract：:Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8080497
更新日期：2016-08-13 00:00:00
abstract：:The response to resistance training and protein supplementation in the latissimus dorsi muscle (LDM) has never been investigated. We investigated the effects of resistance training (RT) and protein supplementation on muscle mass, strength, and fiber characteristics of the LDM. Eighteen healthy young subjects were rand...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8060331
更新日期：2016-06-01 00:00:00
abstract：:In this study, we investigated the beneficial effects of milk biofortified with antioxidants on the health of children. Two experiments were conducted: experiment one evaluated the milk of 24 Jersey dairy cows (450 ± 25 kg of body weight (BW); 60 ± 30 days in milk dry matter intake (DIM)) given different diet treatmen...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11061218
更新日期：2019-05-29 00:00:00
abstract：:Underlying mechanisms associated with the development of abnormal metabolic phenotypes among obese individuals are not yet clear. Our aim is to investigate differences in plasma metabolomics profiles between normal weight (NW) and overweight/obese (Ov/Ob) individuals, with or without metabolic syndrome (MetS). Mass sp...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8060324
更新日期：2016-05-27 00:00:00
abstract：:Whole grains may assist in reducing risk of non-communicable disease, but consumption is limited in many countries. In Australia, the reasons for poor consumption are not well understood. The aim of this study was to investigate consumers' knowledge, attitudes and identification of whole grains, incorporating an explo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082170
更新日期：2020-07-22 00:00:00
abstract：:This cross-sectional study investigates whether calcium intakes from dairy and non-dairy sources, and absolute intakes of various dairy products, are associated with periodontitis. The calcium intake (mg/day) of 135 older Danish adults was estimated by a diet history interview and divided into dairy and non-dairy calc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4091219
更新日期：2012-09-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD), along with obesity, is increasing world-wide and is one of the major causes of chronic hepatic disease. The present study evaluated the ameliorative effect of extract of Psoralea corylifolia L. seed (PCS) on high fat diet-induced NAFLD in C57BL/6 mice after daily administratio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8020083
更新日期：2016-02-06 00:00:00
abstract：:Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strate...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11040894
更新日期：2019-04-20 00:00:00
abstract：:The aim of this study was to assess the association between parent and child sodium (Na) and potassium (K) intake as assessed by 24-h urinary excretion (24hUE). Primary school children and their parent(s) provided one 24-h urine sample and information on cooking and children's discretionary salt use. Valid urine sampl...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8040191
更新日期：2016-04-01 00:00:00
abstract：:A dietary prebiotic is defined as 'a substrate that is selectively utilized by host microorganisms conferring a health benefit'. Although this definition evolved concomitantly with the knowledge and technological developments that accrued in the last twenty years, what qualifies as prebiotic continues to be a matter o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9121376
更新日期：2017-12-20 00:00:00
abstract：:Cardiovascular disease is one of the leading causes of death and disability in the world. Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the vessel wall, is the main feature of cardiovascular disease. Although the amounts of fruits and vegetables present in the diets vary by country, ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10111724
更新日期：2018-11-10 00:00:00
abstract：:Awareness and knowledge of nutrient-dense foods are important for older adults to help them make dietary choices that support a food-first approach to healthy aging. This is especially important since age is a major risk factor for chronic disease and the proportion of older adults in North America is increasing. Bean...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112680
更新日期：2019-11-05 00:00:00
abstract：:Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8060338
更新日期：2016-06-02 00:00:00
abstract：:We determined the effects of altering meal timing and diet composition on temporal glucose homeostasis and physical activity measures. Eight sedentary, overweight/obese men (mean ± SD, age: 36 ± 4 years; BMI: 29.8 ± 1.8 kg/m²) completed two × 12-day (12-d) measurement periods, including a 7-...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10050557
更新日期：2018-04-30 00:00:00
abstract：:There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD). However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear. This study examined whether the effects of isomaltodextrin on gut mi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072088
更新日期：2020-07-15 00:00:00
abstract：:Tyrosinemia type 1 (TT1) treatment with 2-(2-nitro-4-trifluormethyl-benzyl)-1,3-cyclohexanedione (NTBC) and a phenylalanine-tyrosine restricted diet is associated with low phenylalanine concentrations. Phenylalanine supplementation is prescribed without comprehensive consideration about its effect on metabolic control...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu11112816
更新日期：2019-11-18 00:00:00
abstract：:Accuracy in measuring intake of dietary constituents is an important issue in studies reporting the associations between diet and chronic diseases. We modified a Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire (FFQ) to include foods of interest in the field of Alzheime...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123605
更新日期：2020-11-24 00:00:00
abstract：:The objective of this cross-sectional study was to evaluate the relationship between micronutrient status and obesity, lipids, insulin resistance and chronic inflammation in children. Weight, height, waist circumference and body composition (dual-energy X-ray absorptiometry (DEXA)) were determined in 197 school-aged c...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5125012
更新日期：2013-12-10 00:00:00
