Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy.

Abstract:

AIM:To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN). PATIENTS-METHODS:In this prospective, double-blind, placebo-controlled study, 85 patients with Diabetes Mellitus Type 2 (DMT2) were randomly assigned, either to receive the combination of four elements (active group, n = 43), or placebo (n = 42) for 12 months. We used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measured the vibration perception threshold (BIO), and Cardiovascular Autonomic Reflex Tests (CARTs). Nerve function was assessed by DPN Check [sural nerve conduction velocity (SNCV) and amplitude (SNAP)]. Pain (PS) and quality of life (QL) questionnaires were administered. RESULTS:At follow-up, BIO, MNSIQ, QL, PAIN, and SNCV, SNAP, and B12 levels had significantly improved inactive group (p <0.001, p <0.001, p <0.001, p <0.001, p = 0.027, p = 0.031, and p <0.001 respectively), whereas the inplacebo group MCR (mean circular resultant) and PAIN deteriorated (p <0.001, p <0.001). The changes in MNSIQ, QL, SNCV, BIO, and PAIN differed significantly between groups (p <0.001, p <0.001, p = 0.031, p <0.001, and p <0.001 respectively). CONCLUSIONS:The combination of the four elements in one tablet for 12 months in patients with DMT2 improved all indices of peripheral neuropathy, including SNAP and SNCV, pain, and Quality of Life perception, except CARTs and MNSIE.

journal_name

Nutrients

journal_title

Nutrients

authors

Didangelos T,Karlafti E,Kotzakioulafi E,Kontoninas Z,Margaritidis C,Giannoulaki P,Kantartzis K

doi

10.3390/nu12113254

subject

Has Abstract

pub_date

2020-10-23 00:00:00

issue

11

issn

2072-6643

pii

nu12113254

journal_volume

12

pub_type

杂志文章
  • Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease.

    abstract::Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobu...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10050602

    authors: Reunala T,Salmi TT,Hervonen K,Kaukinen K,Collin P

    更新日期:2018-05-12 00:00:00

  • The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder.

    abstract::Obesity and weight gain in bipolar disorder (BD) have multifactorial underlying causes such as medication side effects, atypical depressive symptomatology, genetic variants, and disturbances in the neuro-endocrinal system. Therefore, we aim to explore the associations between food craving (FC), clinical parameters, ps...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13010076

    authors: Platzer M,Fellendorf FT,Bengesser SA,Birner A,Dalkner N,Hamm C,Lenger M,Maget A,Pilz R,Queissner R,Reininghaus B,Reiter A,Mangge H,Zelzer S,Kapfhammer HP,Reininghaus EZ

    更新日期:2020-12-29 00:00:00

  • Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project.

    abstract::As malnutrition is common in patients with Alzheimer's disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051161

    authors: Doorduijn AS,Visser M,van de Rest O,Kester MI,de Leeuw FA,Boesveldt S,Fieldhouse JLP,van den Heuvel EGHM,Teunissen CE,Scheltens P,van der Flier WM,de van der Schueren MAE

    更新日期:2019-05-23 00:00:00

  • Milk Polar Lipids: Underappreciated Lipids with Emerging Health Benefits.

    abstract::Milk fat is encased in a polar lipid-containing tri-layer milk fat globule membrane (MFGM), composed of phospholipids (PLs) and sphingolipids (SLs). Milk PLs and SLs comprise about 1% of total milk lipids. The surfactant properties of PLs are important for dairy products; however, dairy products vary considerably in t...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12041001

    authors: Anto L,Warykas SW,Torres-Gonzalez M,Blesso CN

    更新日期:2020-04-04 00:00:00

  • Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults.

    abstract::Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer's disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7105391

    authors: Yuan L,Liu J,Dong L,Cai C,Wang S,Wang B,Xiao R

    更新日期:2015-09-24 00:00:00

  • Carbohydrate and Glutamine Supplementation Attenuates the Increase in Rating of Perceived Exertion during Intense Exercise in Hypoxia Similar to 4200 m.

    abstract::The rating of perceived exertion (RPE) indicates the feeling of fatigue. However, hypoxia worsens the condition and can worsen RPE. We evaluated whether carbohydrate and glutamine supplementation alters RPE and physiological markers in running at 70% peak oxygen uptake until exhaustion in a simulated altitude of 4500 ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123797

    authors: Caris AV,Thomatieli-Santos RV

    更新日期:2020-12-11 00:00:00

  • Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress.

    abstract::The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the present study, we discovered that leucine-h...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11092161

    authors: Ano Y,Kita M,Kitaoka S,Furuyashiki T

    更新日期:2019-09-09 00:00:00

  • Maternal Diet Quality, Body Mass Index and Resource Use in the Perinatal Period: An Observational Study.

    abstract::The impact of pre-pregnancy obesity and maternal diet quality on the use of healthcare resources during the perinatal period is underexplored. We assessed the effects of body mass index (BMI) and diet quality on the use of healthcare resources, to identify whether maternal diet quality may be effectively targeted to r...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12113532

    authors: Szewczyk Z,Weaver N,Rollo M,Deeming S,Holliday E,Reeves P,Collins C

    更新日期:2020-11-17 00:00:00

  • Development of a Choline Database to Estimate Australian Population Intakes.

    abstract::The AUSNUT 2011-13 food composition database was expanded to include Australian choline values. The development began with a systematic literature review of published studies. Analytical data from the food studies were extracted and aligned with their equivalent AUSNUT food identification code. Global food composition...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11040913

    authors: Probst Y,Guan V,Neale E

    更新日期:2019-04-23 00:00:00

  • Different and Unequal: A Qualitative Evaluation of Salient Factors Influencing Energy Intake in Adults with Overweight and Obesity.

    abstract::Environmental factors such as food availability and variety can function as cues for overeating in individuals susceptible to overweight or obesity, but relatively little is known about other types of environmental factors that may also be important. This qualitative study compared and contrasted categories of interna...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11061365

    authors: Dao MC,Messer E,Conigliaro T,Sakaida K,Ouellette AF,Himaras V,Thiron S,Roberts SB

    更新日期:2019-06-18 00:00:00

  • Recent Development of Prebiotic Research-Statement from an Expert Workshop.

    abstract::A dietary prebiotic is defined as 'a substrate that is selectively utilized by host microorganisms conferring a health benefit'. Although this definition evolved concomitantly with the knowledge and technological developments that accrued in the last twenty years, what qualifies as prebiotic continues to be a matter o...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9121376

    authors: La Fata G,Rastall RA,Lacroix C,Harmsen HJM,Mohajeri MH,Weber P,Steinert RE

    更新日期:2017-12-20 00:00:00

  • Global Correlates of Cardiovascular Risk: A Comparison of 158 Countries.

    abstract::The aim of this study was a large-scale ecological analysis of nutritional and other environmental factors potentially associated with the incidence of cardiovascular diseases (CVDs) in the global context. Indicators of CVDs from 158 countries were compared with the statistics of mean intake (supply) of 60 food items ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10040411

    authors: Grasgruber P,Cacek J,Hrazdíra E,Hřebíčková S,Sebera M

    更新日期:2018-03-26 00:00:00

  • Safety and Efficacy of Probiotic Supplementation in Reducing the Incidence of Infections and Modulating Inflammation in the Elderly with Feeding Tubes: A Pilot, Double-Blind, Placebo-Controlled Study, "IntegPRO".

    abstract::A double-blind, placebo-controlled study was performed in a sample of geriatric patients treated with home enteral nutrition (HEN) to analyze the efficacy of a probiotic supplement Proxian®, which contains Lactiplantibacillus plantarum LP01 (LMG P-21021), Lentilactobacillus buchneri Lb26 (DSM 16341), Bifidobacterium a...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13020391

    authors: Orlandoni P,Jukic Peladic N,Amoruso A,Pane M,Di Rosa M,Vedruccio J,Santini F

    更新日期:2021-01-27 00:00:00

  • Prevalence and Predictors of Dietary and Nutritional Supplement Use in the Australian Army: A Cross-Sectional Survey.

    abstract::Dietary supplements (DSs) and nutritional supplements (NSs) can enhance performance, recovery or training adaptations, however, some substances, dosages, and usage protocols are unsafe. Knowledge of the type and extent of use within populations enables strategies to be formulated to promote safe and effective use (whe...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11071462

    authors: Baker B,Probert B,Pomeroy D,Carins J,Tooley K

    更新日期:2019-06-27 00:00:00

  • Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease.

    abstract::Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid⁻base balance. Major det...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10040512

    authors: Siener R

    更新日期:2018-04-20 00:00:00

  • Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling.

    abstract::Prolonged effects of dietary acid intake on acid-base status and kidney function have not yet been studied in an intervention study in healthy subjects. Dietary acid load can be estimated by calculating the potential renal acid load (PRAL) of foods. Effects of low-PRAL and moderate-PRAL diets on acid-base status and k...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10030323

    authors: Hietavala EM,Ihalainen JK,Frassetto LA,Schumann M,Eklund D,Pitkänen H,Häkkinen K,Mero AA

    更新日期:2018-03-08 00:00:00

  • Effects of a Voluntary Front-of-Pack Nutrition Labelling System on Packaged Food Reformulation: The Health Star Rating System in New Zealand.

    abstract::Interpretive, front-of-pack (FOP) nutrition labels may encourage reformulation of packaged foods. We aimed to evaluate the effects of the Health Star Rating (HSR), a new voluntary interpretive FOP labelling system, on food reformulation in New Zealand. Annual surveys of packaged food and beverage labelling and composi...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9080918

    authors: Mhurchu CN,Eyles H,Choi YH

    更新日期:2017-08-22 00:00:00

  • Studying the Relationship of Intermittent Fasting and β-Amyloid in Animal Model of Alzheimer's Disease: A Scoping Review.

    abstract::We examined the evidence for intermittent fasting (IF) as a preventative tool to influence β-amyloid in animal models of Alzheimer's disease (AD). A Scopus, Ovid, PubMed, and Web of Science (WoS), search yielded 29 results using the keywords "amyloid beta", "intermittent fasting", "intermittent caloric restriction", "...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12103215

    authors: Nasaruddin ML,Syed Abd Halim SA,Kamaruzzaman MA

    更新日期:2020-10-21 00:00:00

  • Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study.

    abstract::Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot stu...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu11061386

    authors: Panizza CE,Lim U,Yonemori KM,Cassel KD,Wilkens LR,Harvie MN,Maskarinec G,Delp EJ,Lampe JW,Shepherd JA,Le Marchand L,Boushey CJ

    更新日期:2019-06-20 00:00:00

  • Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.

    abstract::The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10111785

    authors: Lankinen M,Uusitupa M,Schwab U

    更新日期:2018-11-16 00:00:00

  • Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa.

    abstract::In South Africa, haemoglobin (Hb) is measured to screen for iron deficiency (ID). However, low levels of Hb are only a late stage indicator of ID. Furthermore, Hb values are generally not adjusted for altitude even though recommended by WHO. We determined the Hb threshold with the highest combined sensitivity and spec...

    journal_title:Nutrients

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3390/nu12030633

    authors: Silubonde TM,Baumgartner J,Ware LJ,Malan L,Smuts CM,Norris S

    更新日期:2020-02-27 00:00:00

  • The Effect of Walnut Consumption on n-3 Fatty Acid Profile of Healthy People Living in a Non-Mediterranean West Balkan Country, a Small Scale Randomized Study.

    abstract::People living in non-Mediterranean West Balkan countries have diets with a low n-3 polyunsaturated fatty acid (PUFA) content. Walnuts, a traditional Serbian food, could be an excellent source of n-3 PUFA. The first sub-study evaluated the fatty acid and mineral content of Serbian walnuts, demonstrating that walnuts ha...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu12010192

    authors: Petrović-Oggiano G,Debeljak-Martačić J,Ranković S,Pokimica B,Mirić A,Glibetić M,Popović T

    更新日期:2020-01-10 00:00:00

  • Proteomics Analysis Reveals the Implications of Cytoskeleton and Mitochondria in the Response of the Rat Brain to Starvation.

    abstract::Long-term starvation provokes a metabolic response in the brain to adapt to the lack of nutrient intake and to maintain the physiology of this organ. Here, we study the changes in the global proteomic profile of the rat brain after a seven-day period of food deprivation, to further our understanding of the biochemical...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11020219

    authors: Cuevas-Fernández B,Fuentes-Almagro C,Peragón J

    更新日期:2019-01-22 00:00:00

  • Stabilization of Vitamin D in Pea Protein Isolate Nanoemulsions Increases Its Bioefficacy in Rats.

    abstract::Micronutrient delivery formulations based on nanoemulsions can enhance the absorption of nutrients and bioactives, and thus, are of great potential for food fortification and supplementation strategies. The aim was to evaluate the bioefficacy of vitamin D (VitD) encapsulated in nanoemulsions developed by sonication an...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010075

    authors: Almajwal AM,Abulmeaty MMA,Feng H,Alruwaili NW,Dominguez-Uscanga A,Andrade JE,Razak S,ElSadek MF

    更新日期:2019-01-02 00:00:00

  • Persistent Intraepithelial Lymphocytosis in Celiac Patients Adhering to Gluten-Free Diet Is Not Abolished Despite a Gluten Contamination Elimination Diet.

    abstract::The gluten-free diet (GFD) is the only validated treatment for celiac disease (CD), but despite strict adherence, complete mucosal recovery is rarely obtained. The aim of our study was to assess whether complete restitutio ad integrum could be achieved by adopting a restrictive diet (Gluten Contamination Elimination D...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8090525

    authors: Zanini B,Marullo M,Villanacci V,Salemme M,Lanzarotto F,Ricci C,Lanzini A

    更新日期:2016-08-26 00:00:00

  • COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation.

    abstract::The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the vulnerable and immunocomprom...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12051466

    authors: Zabetakis I,Lordan R,Norton C,Tsoupras A

    更新日期:2020-05-19 00:00:00

  • Trends in Food Consumption Patterns of US Infants and Toddlers from Feeding Infants and Toddlers Studies (FITS) in 2002, 2008, 2016.

    abstract::The Feeding Infants and Toddlers Study (FITS) is the largest survey of dietary intake among infants and young children in the United States. Dietary patterns in early childhood are a key component of prevention of diet-related chronic diseases, yet little is known about how food consumption patterns of infants and you...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11112807

    authors: Duffy EW,Kay MC,Jacquier E,Catellier D,Hampton J,Anater AS,Story M

    更新日期:2019-11-17 00:00:00

  • Combination Antioxidant/NSAID Therapies and Oral/Topical Ocular Delivery Modes for Prevention of Oxygen-Induced Retinopathy in a Rat Model.

    abstract::Given the complexity of oxygen-induced retinopathy (OIR), we tested the hypothesis that combination therapies and modes of administration would synergistically optimize efficacy for prevention of OIR. Newborn rats were exposed to neonatal intermittent hypoxia (IH) from the first day of life (P0) until P14 during which...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12071980

    authors: Beharry KD,Cai CL,Siddiqui F,D'Agrosa C,Zangaladze A,Mustafa G,Qadri A,Duggan TJ,Aranda JV

    更新日期:2020-07-03 00:00:00

  • Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets.

    abstract::Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu10081063

    authors: Rådjursöga M,Lindqvist HM,Pedersen A,Karlsson BG,Malmodin D,Ellegård L,Winkvist A

    更新日期:2018-08-10 00:00:00

  • Vitamin a deficiency and alterations in the extracellular matrix.

    abstract::Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic de...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu6114984

    authors: Barber T,Esteban-Pretel G,Marín MP,Timoneda J

    更新日期:2014-11-10 00:00:00