Abstract:
:The gluten-free diet (GFD) is the only validated treatment for celiac disease (CD), but despite strict adherence, complete mucosal recovery is rarely obtained. The aim of our study was to assess whether complete restitutio ad integrum could be achieved by adopting a restrictive diet (Gluten Contamination Elimination Diet, GCED) or may depend on time of exposure to GFD. Two cohorts of CD patients, with persisting Marsh II/Grade A lesion at duodenal biopsy after 12-18 months of GFD (early control) were identified. Patients in Cohort A were re-biopsied after a three-month GCED (GCED control) and patients in Cohort B were re-biopsied after a minimum of two years on a standard GFD subsequent to early control (late control). Ten patients in Cohort A and 19 in Cohort B completed the study protocol. There was no change in the classification of duodenal biopsies in both cohorts. The number of intraepithelial lymphocytes, TCRγδ+ (T-Cell Receptor gamma delta) T cell and eosinophils significantly decreased at GCED control (Cohort A) and at late control (Cohort B), compared to early control. Duodenal intraepithelial lymphocytosis persisting in CD patients during GFD is not eliminated by a GCED and is independent of the length of GFD. [NCT 02711696].
journal_name
Nutrientsjournal_title
Nutrientsauthors
Zanini B,Marullo M,Villanacci V,Salemme M,Lanzarotto F,Ricci C,Lanzini Adoi
10.3390/nu8090525subject
Has Abstractpub_date
2016-08-26 00:00:00issue
9issn
2072-6643pii
nu8090525journal_volume
8pub_type
杂志文章相关文献
Nutrients文献大全abstract::Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061872
更新日期:2020-06-23 00:00:00
abstract::Despite their low cost and high nutrient density, the contribution of eggs to nutrient intake and dietary quality among Mexican-American postpartum women has not been evaluated. Nutrient intake and dietary quality, as assessed by the Healthy Eating Index 2010 (HEI-2010), were measured in habitually sedentary overweigh...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7105402
更新日期:2015-10-02 00:00:00
abstract::Allium genus plants, such as leek (Allium porrum), are rich sources of anti-inflammatory and anti-oxidant secondary metabolites; this is of interest because it demonstrates their suitability as pharmacological alternatives for inflammatory processes, including allergy treatment. The composition of methanolic leek extr...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061303
更新日期:2019-06-08 00:00:00
abstract::Shifting of energy intake towards a later time in the day is associated with an increased risk of obesity in adults. However, there is a lack of data for adolescents. The aim of this study was to investigate adolescents eveningness in energy intake (EV) and its association with anthropometric indicators of nutritional...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061710
更新日期:2020-06-07 00:00:00
abstract::Previous research indicated that preschoolers of lower socioeconomic status (SES) consume less healthy beverages than high SES preschoolers. The purpose of this study is to investigate the mediating role of parenting practices in the relationship between SES and plain water, soft drink and prepacked fruit juice (FJ) c...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100591
更新日期:2016-09-23 00:00:00
abstract::The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. Several studies have addressed lactic fermentation plus addition of e...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7042134
更新日期:2015-03-25 00:00:00
abstract::Special Operations Forces (SOF) regularly engage in physically demanding combat operations and field training exercises, resulting in high daily energy expenditure, and thus increased energy requirements. However, the majority of studies assessing energy requirements of SOF have been conducted on soldiers going throug...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6051945
更新日期:2014-05-12 00:00:00
abstract::Vitamin D (VD) plays an essential role in mineral homeostasis and bone remodeling. A number of different VD-related genes (VDRG) are required for the metabolic activation of VD and the subsequent induction of its target genes. They include a set of genes that encode for VD-binding protein, metabolic enzymes, and the V...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12040962
更新日期:2020-03-30 00:00:00
abstract::As incomes steadily increase globally, traditional diets have been displaced by diets that are usually animal-based with a high content of "empty calories" or refined sugars, refined fats, and alcohol. Dietary transition coupled with the expansion of urbanization and lower physical activity have been linked to the glo...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10020173
更新日期:2018-02-03 00:00:00
abstract::Infant dietary patterns tend to be insufficient sources of fruits, vegetables, and fiber, as well as excessive in salt, added sugars, and overall energy. Despite the serious long-term health risks associated with suboptimal fruit and vegetable intake, a large percentage of infants and toddlers in the U.S. do not consu...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8050316
更新日期:2016-05-21 00:00:00
abstract::Obesity in the postmenopausal period is associated with an increased risk of cardiovascular diseases in women. One of the key drivers of cardiovascular risk is endothelial dysfunction; thus, this is also a crucial point for studies on new therapeutic methods of cardioprotective properties. The aim of the current study...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10111672
更新日期:2018-11-05 00:00:00
abstract::Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumptio...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9050521
更新日期:2017-05-19 00:00:00
abstract::Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subj...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072065
更新日期:2020-07-11 00:00:00
abstract::Policies to promote healthy foods in early care and education (ECE) in the United States exist, but few have been prospectively evaluated. In South Carolina, a statewide program serving low-income children in ECE enacted new policies promoting healthy foods. We conducted an evaluation to measure changes in dietary int...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061753
更新日期:2020-06-11 00:00:00
abstract::Matcha Green Tea Powder contains a variety of active ingredients beneficial to health, such as tea catechins, lutein and vitamin K. It is also known that these ingredients confer benefits upon cognitive functions of elderly people. Therefore, we aimed to investigate the relationship between a daily supplementation of ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123639
更新日期:2020-11-26 00:00:00
abstract::Fruit and vegetables (F&V) are imperative for good health, yet less than one per cent of Australian children consume these food groups in sufficient quantities. As guided by Social Cognitive Theory (SCT), this paper aimed to: (i) understand key informant perspectives of the amount, types and quality of F&V consumed by...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111603
更新日期:2018-11-01 00:00:00
abstract::We have identified a clinical association between self-reported non-celiac wheat sensitivity (NCWS) and Familial Mediterranean Fever (FMF). Objectives: A) To determine whether a 2-week double-blind placebo-controlled (DBPC) cross-over wheat vs. rice challenge exacerbates the clinical manifestations of FMF; B) to evalu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041127
更新日期:2020-04-17 00:00:00
abstract::Chicken extract, which is rich in anserine and carnosine, has been widely taken in Asian countries as a traditional remedy with various aims, including attenuation of psychological fatigue. The effects of consuming BRAND'S Essence of Chicken (EOC) or a placebo on 46 young adults' responses to a standard psychological ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7020887
更新日期:2015-01-29 00:00:00
abstract::The present study compares the bioavailability of vitamin B12 (B12) of dairy products or synthetic B12, using the pig as an experimental model for humans. Eleven pigs were used in a cross-over design to assess the net portal drained viscera (PDV) flux of blood plasma B12 after ingestion of tofu (TF; devoid of B12), Sw...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091134
更新日期:2018-08-21 00:00:00
abstract::Our aim is evaluating the changes in weight and dietary habits in a sample of outpatients with obesity after 1 month of enforced lockdown during the COVID-19 pandemic in Northern Italy. In this observational retrospective study, the patients of our Obesity Unit were invited to answer to a 12-question multiple-choice q...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072016
更新日期:2020-07-07 00:00:00
abstract::Pulses (e.g., lentil, common bean, chickpea, and dry pea) are linked to a myriad of positive human and environmental health impacts, making them an ideal food for wise and conscientious global citizens. In addition, pulses are affordable and shelf-stable. The combination of these factors, an elevated consumer interest...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113500
更新日期:2020-11-14 00:00:00
abstract::Poor diet quality and obesity, especially abdominal obesity, have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available and inexpensive inflammation biomarker. The aim of the present study was to determine the association of dietary patterns and obesity with an inflammato...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030855
更新日期:2020-03-23 00:00:00
abstract::Hand osteoarthritis (OA) is a degenerative joint disease which leads to pain and disability. Recent studies focus on the role of obesity and metabolic syndrome in inducing or worsening joint damage in hand OA patients, suggesting that chronic low-grade systemic inflammation may represent a possible linking factor. The...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12113469
更新日期:2020-11-12 00:00:00
abstract::The effects of different carbohydrate-protein (CHO + Pro) beverages were compared during recovery from cycling exercise. Twelve male cyclists (VO(2peak): 65 ± 7 mL/kg/min) completed ~1 h of high-intensity intervals (EX1). Immediately and 120 min following EX1, subjects consumed one of three calorically-similar beverag...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu4070568
更新日期:2012-07-01 00:00:00
abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5041186
更新日期:2013-04-09 00:00:00
abstract::The current study assesses whether the use of a gluten-free diet (GFD) is sufficient for maintaining correct iron status in children with celiac disease (CD). The study included 101 children. The celiac group (n = 68) included children with CD, with long (> 6 months) (n = 47) or recent (< 6 months) (n = 21) adherence ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030844
更新日期:2020-03-21 00:00:00
abstract::Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on di...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113297
更新日期:2020-10-28 00:00:00
abstract::Age-related macular degeneration and retinitis pigmentosa are leading causes of blindness and share a pathological feature, which is photoreceptor degeneration. To date, the lack of a potential treatment to prevent such diseases has raised great concern. Photoreceptor degeneration can be accelerated by excessive light...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121991
更新日期:2018-12-15 00:00:00
abstract::The aim of this study was to determine whether an association exists between children's and parental dietary patterns (DP), and whether the number of shared meals or soft drink availability during meals strengthens this association. In 2013/2014 the I.Family study cross-sectionally assessed ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9020126
更新日期:2017-02-10 00:00:00
abstract::Dietary supplement use may modify the risk of periodontal disease but effects on wound healing after periodontal procedures are less clear. This study characterized dietary supplement use by male and female patients (n = 376) attending a periodontal clinic-information that is essential for evidence-based intervention ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5041110
更新日期:2013-04-02 00:00:00