Abstract：
:Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects on endothelial function after consumption of Sakurajima radish by humans. Our results show that Sakurajima radish contains approximately 60 times more trigonelline than other radishes and squashes. Additionally, no significant differences were observed between varieties of Sakurajima radish, suggesting that any type of Sakurajima radish can be ingested for trigonelline supplementation. The effects of cooking and processing Sakurajima radish were also evaluated, as were the effects of freezing, and changes in osmotic pressure and pH. A first-in-human trial using Sakurajima radish showed that ingestion of 170 g/day of Sakurajima radish for ten days increased blood trigonelline concentrations and significantly improved flow-mediated dilation, which is a measure of vascular endothelial function. Overall, our findings suggest that the trigonelline contained in Sakurajima radish may contribute to improved human vascular endothelial function. Hence, Sakurajima radish may enhance vascular endothelial function as a functional food.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Sasaki M,Nonoshita Y,Kajiya T,Atsuchi N,Kido M,Chu DC,Juneja LR,Minami Y,Kajiya Kdoi
10.3390/nu12061872subject
Has Abstractpub_date
2020-06-23 00:00:00issue
6issn
2072-6643pii
nu12061872journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are increased in plasma lipids and blood cell membranes in response to supplementation. Whilst arachidonic acid (AA) is correspondingly decreased, the effect on other fatty acids (FA) is less well described and there may be site-specific differences. In respon...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7085285
更新日期：2015-08-03 00:00:00
abstract：:Age-related macular degeneration and retinitis pigmentosa are leading causes of blindness and share a pathological feature, which is photoreceptor degeneration. To date, the lack of a potential treatment to prevent such diseases has raised great concern. Photoreceptor degeneration can be accelerated by excessive light...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10121991
更新日期：2018-12-15 00:00:00
abstract：:Emerging research demonstrates polyphenol-rich diets like the Mediterranean diet may play a role in improving the outcomes of adult cancer therapy. To date, there are no trials assessing the intake or efficacy of polyphenol-rich diets in childhood cancer patients. In this study we collected dietary data on 59 childhoo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112835
更新日期：2019-11-19 00:00:00
abstract：:Selenium is an essential trace element which is incorporated in the form of a rare amino acid, the selenocysteine, into an important group of proteins, the selenoproteins. Among the twenty-five selenoprotein genes identified to date, several have important cellular functions in antioxidant defense, cell signaling and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071524
更新日期：2019-07-04 00:00:00
abstract：:Exercise has beneficial effects on our health by stimulating metabolic activation of skeletal muscle contraction. Caffeine is a powerful metabolic stimulant in the skeletal muscle that has ergogenic effects, including enhanced muscle power output and endurance capacity. In the present study, we aim to characterize the...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081819
更新日期：2019-08-07 00:00:00
abstract：:The objective of this study was to examine the influence of improved information and educational messages on outer packaging of a micronutrient powder (MNP), locally known as “Taburia”, on knowledge and adherence to recommended use. A community-based cluster randomized controlled trial was conducted among ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10060747
更新日期：2018-06-08 00:00:00
abstract：BACKGROUND:Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is hig...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12061743
更新日期：2020-06-10 00:00:00
abstract：:Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the associ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11050966
更新日期：2019-04-27 00:00:00
abstract：:(1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-α, IL-6, IL-1β). However, data are scarce on retinol binding protein 4 (RBP4) in humans. We examined the associations among serum carotenoids, RBP4 and several inflammatory markers in a Chinese population. (2) Methods: This co...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10030260
更新日期：2018-02-25 00:00:00
abstract：:The present study aimed to assess energy intake, nutrient profile and food sources in Spanish children participating in the EsNuPI ("Estudio Nutricional en Población Infantil Española") study. Plausibility of energy intake and adequacy of nutrient intakes to international recommendations were analyzed in a final sampl...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040893
更新日期：2020-03-25 00:00:00
abstract：:In 2016⁻2017, we conducted and published a systematic review on caffeine safety that set out to determine whether conclusions that were presented in the heavily cited Health Canada assessment, remain supported by more recent data. To that end, we reviewed data from 380 studies published between June 2001 and June 2015...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101536
更新日期：2018-10-18 00:00:00
abstract：:It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been asso...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2040408
更新日期：2010-04-01 00:00:00
abstract：:Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index in children, and with f...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112810
更新日期：2019-11-18 00:00:00
abstract：BACKGROUND:Bifidobacterium represents an important early life microbiota member. Specific bifidobacterial components, exopolysaccharides (EPS), positively modulate host responses, with purified EPS also suggested to impact microbe-microbe interactions by acting as a nutrient substrate. Thus, we determined the longitudi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040948
更新日期：2020-03-29 00:00:00
abstract：:Amidst the ongoing societal and economic shifts in the Eastern Mediterranean region (EMR), this study aims at investigating temporal trends in food consumption and nutrient intakes among Lebanese adults, by age and sex. Data were derived from two national cross-sectional surveys conducted in Lebanon during two time pe...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081738
更新日期：2019-07-27 00:00:00
abstract：:Vitamin D and calcium supplementation have been posited to improve body composition and different formulations of calcium may impact bioavailability. However, data are lacking regarding the combinatorial effects of exercise, diet, and calcium and/or vitamin D supplementation on body composition changes in post-menopau...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030713
更新日期：2020-03-07 00:00:00
abstract：:Flavonols and flavanones are polyphenols exerting many healthy biological activities. They are often glycosylated by rutinose, which hampers absorption in the small intestine. Therefore they require the gut microbiota to release the aglycone and enable colonic absorption. The role of the gut microbiota and bifidobacte...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7042788
更新日期：2015-04-14 00:00:00
abstract：:Necrotizing enterocolitis (NEC), the first cause of short bowel syndrome (SBS) in the neonate, is a serious neonatal gastrointestinal disease with an incidence of up to 11% in preterm newborns less than 1500 g of birth weight. The rate of severe NEC requiring surgery remains high, and it is estimated between 20-50%. N...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13020340
更新日期：2021-01-24 00:00:00
abstract：:One of the brief methods enabling the assessment of the zinc intake and identification of individuals characterized by insufficient zinc intake, is zinc-specific food frequency questionnaire. The aim of the study was to assess the validity and reproducibility of the elaborated zinc-specific food frequency questionnair...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010104
更新日期：2018-01-19 00:00:00
abstract：:Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091967
更新日期：2019-08-21 00:00:00
abstract：BACKGROUND:Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS:A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010095
更新日期：2018-01-15 00:00:00
abstract：:Breastfeeding is recommended beyond 12 months of age, but little is known about the contribution of breastmilk and infant formula to the nutritional intake of toddlers as they transition to a family diet in the second year of life. This study is a cross-sectional analysis of data collected from a birth cohort study in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8080501
更新日期：2016-08-16 00:00:00
abstract：:Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D, are commonly investigated using animal models induced by a dietary intervention. In spite of significant research contributions, an...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123650
更新日期：2020-11-27 00:00:00
abstract：:This study aimed to investigate the effect of a high-protein diet on growth, body composition, and protein nutritional status of young rats. Newly-weaned Wistar rats, weighing 45-50 g, were distributed in two experimental groups, according to their diets, which contained 12% (G12) or 26% protein (G26), over a period o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4091328
更新日期：2012-09-01 00:00:00
abstract：:Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In recent decades, there has been an exceptional number of ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010139
更新日期：2020-12-31 00:00:00
abstract：:Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used t...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113245
更新日期：2020-10-23 00:00:00
abstract：:This review discusses the personalised dietary approach with respect to inflammatory bowel disease (IBD). It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. It also discusses food intoler...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11071532
更新日期：2019-07-05 00:00:00
abstract：:Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increase...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10060760
更新日期：2018-06-13 00:00:00
abstract：:A growing literature is dedicated to the understanding of carotenoid beneficial health effects. However, the absorption process of this broad family of molecules is still poorly understood. These highly lipophilic plant metabolites are usually weakly absorbed. It was long believed that β-carotene absorption (the princ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040838
更新日期：2019-04-13 00:00:00
abstract：:Sociodemographic differences in dietary consumption were observed in different populations. The current study aimed to identify sociodemographic and lifestyle determinants of diet quality and to investigate the differences in diet quality between the three main language regions of Switzerland. Using data of the Swiss ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010126
更新日期：2019-01-09 00:00:00
