Abstract：
:Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index in children, and with fasting serum triglyceride levels in healthy elderly subjects. An independent study also reported a correlation between SDC4 and the risk of coronary artery disease in middle-aged patients. Here, we investigated whether deletion of Sdc4 promotes metabolic derangements associated with diet-induced obesity by feeding homozygous male and female Sdc4-deficient (Sdc4-/-) mice and their age-matched wild-type (WT) mice a high-fat diet (HFD). We found that WT and Sdc4-/- mice gained similar weight. However, while no differences were observed in males, HFD-fed female Sdc4-/- mice exhibited a higher percentage of body fat mass than controls and displayed increased levels of plasma total cholesterol, triglyceride, and glucose, as well as reduced whole-body insulin sensitivity. Additionally, they had an increased adipocyte size and macrophage infiltration in the visceral adipose tissue, and higher triglyceride and fatty acid synthase levels in the liver. Together with our previous human genetic findings, these results provide evidence of an evolutionarily conserved role of SDC4 in adiposity and its complications.
journal_name
Nutrientsjournal_title
Nutrientsauthors
De Luca M,Vecchie' D,Athmanathan B,Gopalkrishna S,Valcin JA,Swain TM,Sertie R,Wekesa K,Rowe GC,Bailey SM,Nagareddy PRdoi
10.3390/nu11112810subject
Has Abstractpub_date
2019-11-18 00:00:00issue
11issn
2072-6643pii
nu11112810journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Prenatal iron and folic acid (IFA) supplements are offered free to all pregnant women in Malawi to reduce maternal anemia and improve birth outcomes. We investigated the association between self-reported compliance to IFA intake and risk of low birth weight (LBW). Pregnant women who attended Bwaila Maternity Wing of L...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091275
更新日期：2018-09-10 00:00:00
abstract：:Neurological dementias such as Alzheimer's disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregate...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113480
更新日期：2020-11-13 00:00:00
abstract：:Studies on fermentable oligo-, di-, and monosaccharides as well as polyols (FODMAPs) intake in older adults are lacking. This study investigated the relationship between gastrointestinal (GI) symptoms and FODMAPs in aged care residents. The Gastrointestinal Symptom Rating Score questionnaire modified for patients with...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9101083
更新日期：2017-09-29 00:00:00
abstract：:Responsive feeding is crucial to the formation of life-long healthy eating behavior. Few studies have examined maternal responsive feeding in early infancy among a Chinese population. This prospective study describes maternal responsive feeding and factors associated with maternal responsive feeding, with emphasis on ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061766
更新日期：2020-06-12 00:00:00
abstract：:Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010059
更新日期：2020-12-27 00:00:00
abstract：:While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-a...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11061436
更新日期：2019-06-25 00:00:00
abstract：:Despite several papers having been published on the association between adiposity and the risk of metabolic syndrome (MetS), it is still difficult to determine unambiguously which of the indices of nutritional status is the best to identify MetS. The aim of this study was to analyze the ability of six anthropometric i...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112598
更新日期：2019-10-29 00:00:00
abstract：:Observational studies provide evidence that a higher intake of protein from plant-based foods and certain animal-based foods is associated with a lower risk for type 2 diabetes. However, there are few distinguishable differences between the glucoregulatory qualities of the proteins in plant-based foods, and it is like...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8080446
更新日期：2016-07-23 00:00:00
abstract：:Carrots are consumed worldwide. Several meta-analysis studies on carrot consumption have indicated that carrots play a central role as a protecting vegetable against development of different types of cancers. A cancer-preventive role of carrots is plausible because they are the main dietary source of the bioactive pol...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020332
更新日期：2020-01-27 00:00:00
abstract：:The rising prevalence of overweight and obesity is a global concern, increasing the risk of numerous non-communicable diseases and reducing quality of life. A healthy diet and exercise remain the cornerstone treatments for obesity. However, adherence rates can be low and the effectiveness of these interventions is oft...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12051398
更新日期：2020-05-13 00:00:00
abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer are at risk of prolonged hospital stay for postoperative malnutrition. Postoperative early oral feeing is a part of the "enhanced recovery after surgery protocol" for coping with this risk. However, the usefulness of early oral intake during perioperatively i...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061338
更新日期：2019-06-14 00:00:00
abstract：:In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients receive...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123873
更新日期：2020-12-18 00:00:00
abstract：:Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease the environmental impact of animal agriculture, but also exert biological activities with significant health-beneficial effects. Wheat is the most important food grain source in the world. However, n...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061673
更新日期：2020-06-04 00:00:00
abstract：:Consuming excessive amounts of energy as dietary fat for several days or weeks can impair glycemic control and reduce insulin sensitivity in healthy adults. However, individuals who demonstrate binge eating behavior overconsume for much shorter periods of time; the metabolic consequences of such behavior remain unknow...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu9080818
更新日期：2017-07-29 00:00:00
abstract：:A pregnant woman's diet consists of many products, such as fruits, vegetables, cocoa, tea, chocolate, coffee, herbal and fruit teas, and various commercially available dietary supplements, which contain a high number of biological active plant-derived compounds. Generally, these compounds play beneficial roles in wome...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081958
更新日期：2019-08-20 00:00:00
abstract：:The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9020145
更新日期：2017-02-16 00:00:00
abstract：:Chile has implemented several strategies to decrease the burden of obesity and chronic diseases. The Food Labeling and Advertising Law (Law 20.606) requires a front-of-package "high in" warning label when energy and nutrients of concern (ENC) (total sugar, saturated fats, sodium) exceed established limits. This study ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082371
更新日期：2020-08-08 00:00:00
abstract：:Observational studies have shown that dietary fiber intake is associated with decreased risk of cardiovascular disease. Dietary fiber is a non-digestible form of carbohydrates, due to the lack of the digestive enzyme in humans required to digest fiber. Dietary fibers and lignin are intrinsic to plants and are classifi...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11051155
更新日期：2019-05-23 00:00:00
abstract：:Selenium (Se) is an essential micronutrient known for its antioxidant properties and health benefits, attributed to its presence in selenoproteins as the amino acid, selenocysteine. Selenocysteine lyase (Scly) catalyzes hydrolysis of selenocysteine to selenide and alanine, facilitating re-utilization of Se for de novo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10020159
更新日期：2018-01-31 00:00:00
abstract：:(1) Background: Pregnancy outcomes for both mother and child are affected by many environmental factors. The importance of pregnancy for 'early life programming' is well established and maternal nutrition is an important factor contributing to a favourable environment for developing offspring. We aim to assess whether...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051098
更新日期：2019-05-17 00:00:00
abstract：:Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10010043
更新日期：2018-01-05 00:00:00
abstract：:In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9091017
更新日期：2017-09-14 00:00:00
abstract：:Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020272
更新日期：2019-01-26 00:00:00
abstract：:Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are omega-3 (n-3) fatty acids (FAs) known to influence cardiometabolic markers of health. Evidence suggests that single nucleotide polymorphisms (SNPs) in the fatty acid desaturase 1 and 2 (FADS1/2) gene cluster may influence an individual's response to n-3 FA...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6062290
更新日期：2014-06-16 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of B...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113252
更新日期：2020-10-23 00:00:00
abstract：:Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in h...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5082924
更新日期：2013-07-29 00:00:00
abstract：:The adenylate cyclase 3 (ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10060789
更新日期：2018-06-19 00:00:00
abstract：:Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 time...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11092126
更新日期：2019-09-06 00:00:00
abstract：:Taste is a fundamental determinant of food selection, and inter-individual variations in taste perception may be important risk factors for poor eating habits and obesity. Characterizing differences in taste perception and their influences on dietary intake may lead to an improved understanding of obesity risk and a p...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10080990
更新日期：2018-07-29 00:00:00
abstract：:Many animal studies have been performed with krill oil (KO) and this review aims to summarize their findings and give insight into the mechanism of action of KO. Animal models that have been used in studies with KO include obesity, depression, myocardial infarction, chronic low-grade and ulcerative inflammation and ar...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7053300
更新日期：2015-05-07 00:00:00
