Abstract：
:Carrots are consumed worldwide. Several meta-analysis studies on carrot consumption have indicated that carrots play a central role as a protecting vegetable against development of different types of cancers. A cancer-preventive role of carrots is plausible because they are the main dietary source of the bioactive polyacetylenic oxylipins falcarinol (FaOH) and falcarindiol (FaDOH), which have shown anti-proliferative and anti-inflammatory activity in numerous in vitro studies. In addition, purified FaOH and FaDOH have, in recent studies in colorectal cancer (CRC)-primed rats, demonstrated an anti-neoplastic effect in a dose-dependent manner. The mechanisms of action for this effect appears to be due to inhibition of pro-inflammatory and transcription factor biomarkers for inflammation and cancer. However, studies of the CRC-preventive effect of carrots in a large cohort are still missing. We therefore examined the risk of being diagnosed with CRC as predicted by intake of carrots in a Danish population of 57,053 individuals with a long follow-up. Self-reported intake of raw carrots at a baseline of 2-4 carrots or more each week (>32 g/day) was associated with a 17% decrease in risk of CRC with a mean follow-up of >18 years, compared to individuals with no intake of raw carrots even after extensive model adjustments (HR 0.83 CI 95% 0.71; 0.98). An intake below 2-4 carrots each week (<32 g/day) was not significantly associated with reduced risk of CRC (HR 0.93 CI 95% 0.82; 1.06). The results of this prospective cohort study clearly support the results from studies in cancer-primed rats for CRC and hence a CRC-preventive effect of carrots.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Deding U,Baatrup G,Christensen LP,Kobaek-Larsen Mdoi
10.3390/nu12020332subject
Has Abstractpub_date
2020-01-27 00:00:00issue
2issn
2072-6643pii
nu12020332journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Deoxyschizandrin, a major lignan of Schisandra berries, has been demonstrated to have various biological activities such as antioxidant, hepatoprotective, and antidiabetic effects. However, the anti-cancer effects of deoxyschizandrin are poorly characterized. In the present study, we investigated the anti-cancer effec...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010091
更新日期：2018-01-15 00:00:00
abstract：:ncreasing evidence has suggested an association between dietary magnesium intake and metabolic syndrome. However, previous research examining dietary magnesium intake and metabolic syndrome has produced mixed results. Our objective was to determine the relationship between dietary magnesium intake and metabolic syndro...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu6126005
更新日期：2014-12-22 00:00:00
abstract：:Interventions to promote behaviors to reduce sodium intake require messages tailored to local understandings of the relationship between what we eat and our health. We studied local explanations about hypertension, the relationship between local diet, salt intake, and health status, and participants' opinions about ch...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9070698
更新日期：2017-07-05 00:00:00
abstract：:We aimed to optimize calcium intake among the 2,000+ older women taking part in the Vital D study. Calcium supplementation was not included in the study protocol. Our hypothesis was that annual feedback of calcium intake and informing women of strategies to improve calcium intake can lead to a sustained increase in th...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu20901018
更新日期：2010-09-01 00:00:00
abstract：:Isoflavones are phenolic compounds with a chemical structure similar to that of estradiol. They are present in several vegetables, mainly in legumes such as soy, white and red clover, alfalfa and beans. The most significant food source of isoflavones in humans is soy-derived products. Isoflavones could be used as an a...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123853
更新日期：2020-12-17 00:00:00
abstract：:People seeking asylum in high-income countries are vulnerable to food insecurity due to limited opportunities for social and economic participation. While charity organizations have long sought to provide food aid to those in need, the increasing number of people seeking this assistance requires alternatives. Using a ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10060756
更新日期：2018-06-12 00:00:00
abstract：:Malnutrition among heart-transplant patients may affect survival. The aim was to investigate the survival and nutrition status among male and female heart transplant patients who underwent transplantation, before and 1 year after surgery based on the nutritional risk index (NRI). The medical records of ninety heart-tr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123868
更新日期：2020-12-17 00:00:00
abstract：:Single nutrients or food groups have been associated with physical performance. However, little is known about the association of overall diet quality with hand grip strength (HGS), a predictive parameter in the prognosis of chronic disease morbidity and mortality, or quality of life. This study examined the associati...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071487
更新日期：2019-06-29 00:00:00
abstract：:Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. This study investigated concentrations of fecal and serum bile acids in 36 vegans and 36 omnivores. The reduced rank regression was used to iden...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010047
更新日期：2019-12-23 00:00:00
abstract：:Providing information to consumers through the label is a means for food companies to inform consumers about product's attributes, including the country of origin (COO). In the EU, COO labeling has been made mandatory for several categories of food products, to enable consumers to make informed choices at the point of...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072150
更新日期：2020-07-19 00:00:00
abstract：:The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu6031128
更新日期：2014-03-17 00:00:00
abstract：:Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk o...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6114760
更新日期：2014-10-30 00:00:00
abstract：:The objective of this study was to determine the top frequently reported foods or beverages and the top foods or beverages grouped by broad and specific What We Eat In America (WWEIA) categories for adult age groups of 19 to 35 years, 36 to 55 years, and ≥65 years (n = 16,399) using data drawn from the cross-sectional...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010086
更新日期：2017-01-23 00:00:00
abstract：BACKGROUND:Dyslipidemias are a heterogeneous group of metabolic disorders mainly characterized by an increased risk of atherosclerotic cardiovascular disease (ASCVD) or other conditions, such as acute pancreatitis in hypertriglyceridemia. The aim of this study was to evaluate the effect of diet treatment and nutraceuti...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072056
更新日期：2020-07-10 00:00:00
abstract：:Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2050532
更新日期：2010-05-01 00:00:00
abstract：:Stimulation of the ubiquitin-proteasome pathway-especially E3 ubiquitin ligases Atrogin-1 and MuRF1-is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091040
更新日期：2017-09-20 00:00:00
abstract：:The management of enteral feeds in preterm infants with a hemodynamically significant patent ductus arteriosus (hs-PDA) is a major challenge for neonatologists due to the fear of gastrointestinal (GI) complications. This review aims to analyze the available evidence on the complex relation between the presence and man...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12010083
更新日期：2019-12-27 00:00:00
abstract：:Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild-to-moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated wit...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10030291
更新日期：2018-03-01 00:00:00
abstract：:Home environment and family lifestyle practices have an influence on child obesity risk, thereby making it critical to systematically examine these factors. Thus, parents (n = 489) of preschool children completed a cross-sectional online survey which was the baseline data collection conducted, before randomization, in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060604
更新日期：2017-06-14 00:00:00
abstract：:Physical fitness is a powerful marker of health in youth. Studies in adolescents and adults suggest that higher fat mass is related to worse physical fitness. However, there is limited knowledge whether fat mass and fat-free mass are associated with physical fitness already in preschoolers. Baseline data from the MINI...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu8080473
更新日期：2016-07-30 00:00:00
abstract：:Accumulating epidemiological evidence suggests that anthocyanin intake is associated with reduced risks of cardiometabolic disorders, highlighting the importance of incorporating the phytochemical in our diets. Numerous food-based intervention studies have examined, in controlled meal settings, the role of anthocyanin...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123781
更新日期：2020-12-09 00:00:00
abstract：:Confusion has persisted for decades in the United States (U.S.) over how much plain water to drink, despite national water intake recommendations which are based on high quality scientific evidence. This editorial summarizes the definition, alignment and coordination of evidence that informs the current U.S. adequate ...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu12113359
更新日期：2020-10-31 00:00:00
abstract：:Several recent experimental studies have investigated the effects of caffeine and chlorogenic acid (CGA), representative ingredients of coffee, on nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). However, the results are conflicting, and their effects are yet to be clarified. In the presen...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123886
更新日期：2020-12-18 00:00:00
abstract：:Obesity often has its onset in childhood and can be accompanied by various comorbidities such as functional gastrointestinal disorders and altered gastric myoelectrical activity (GMA). This study investigates whether obesity in childhood and adolescence is already associated with altered GMA, and whether an inpatient ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10060699
更新日期：2018-05-31 00:00:00
abstract：:Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced paracellular permeability across the intestinal epithelium. The complex system of intercellular junctions, including tight junctions (TJs) and adherens junctions (AJs), seals together the epithelial cells to form a continuous layer. T...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111698
更新日期：2018-11-07 00:00:00
abstract：:Docosahexaenoic acid (DHA), a long-chain omega-3 polyunsaturated fatty acid, has been used to treat a range of different conditions, including periodontal disease (PD) and inflammatory bowel disease (IBD). That DHA helps with these oral and gastrointestinal diseases in which inflammation and bacterial dysbiosis play k...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu5083299
更新日期：2013-08-19 00:00:00
abstract：:The phase angle (PhA) seems to be a reliable screening tool for the identification of malnutrition risk in hospitalized children with inflammatory bowel disease (IBD). The aim of the present study was to assess the body composition and nutritional status of hospitalized children and adolescents with IBD by using bioel...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040499
更新日期：2018-04-17 00:00:00
abstract：:Micronutrient deficiencies remain a serious nutritional concern in Bangladesh, especially among rural women of reproductive age (WRA). This study assesses the diet quality of reproductive-aged adolescent girls and adult women (referred to together as WRA in this study), including socio-demographic factors associated w...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13020337
更新日期：2021-01-23 00:00:00
abstract：:Iron deficiency (ID) is the most prevalent nutrient deficiency within the developed world. This is of concern as ID has been shown to affect immunity, thermoregulation, work performance and cognition. Animal flesh foods provide the richest and most bioavailable source of dietary (haem) iron, however, it is unclear whe...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8020089
更新日期：2016-02-16 00:00:00
abstract：:This study aimed to evaluate dietary nutrient intake among Chinese pregnant women by comparison with Chinese Dietary Reference Intakes (DRIs) and to explore the association between dietary nutrients and preterm birth. A case-control design was conducted in Beijing with 130 preterm delivery mothers in case group and 38...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu9030221
更新日期：2017-03-01 00:00:00
