Abstract:
:Docosahexaenoic acid (DHA), a long-chain omega-3 polyunsaturated fatty acid, has been used to treat a range of different conditions, including periodontal disease (PD) and inflammatory bowel disease (IBD). That DHA helps with these oral and gastrointestinal diseases in which inflammation and bacterial dysbiosis play key roles, raises the question of whether DHA may assist in the prevention or treatment of other inflammatory conditions, such as the metabolic syndrome, which have also been linked with inflammation and alterations in normal host microbial populations. Here we review established and investigated associations between DHA, PD, and IBD. We conclude that by beneficially altering cytokine production and macrophage recruitment, the composition of intestinal microbiota and intestinal integrity, lipopolysaccharide- and adipose-induced inflammation, and insulin signaling, DHA may be a key tool in the prevention of metabolic syndrome.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Tabbaa M,Golubic M,Roizen MF,Bernstein AMdoi
10.3390/nu5083299subject
Has Abstractpub_date
2013-08-19 00:00:00pages
3299-310issue
8issn
2072-6643pii
nu5083299journal_volume
5pub_type
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