Abstract:
:Taurine is a ubiquitous sulfur-containing amino acid found in high concentration in most tissues. Because of its involvement in fundamental physiological functions, such as regulating respiratory chain activity, modulating cation transport, controlling inflammation, altering protein phosphorylation and prolonging lifespan, taurine is an important nutrient whose deficiency leads to severe pathology and cell death. However, the mechanism by which taurine deficiency causes cell death is inadequately understood. Therefore, the present study examined the hypothesis that overproduction of reactive oxygen species (ROS) by complex I of the respiratory chain triggers mitochondria-dependent apoptosis in hearts of taurine transporter knockout (TauTKO) mice. In support of the hypothesis, a 60% decrease in mitochondrial taurine content of 3-month-old TauTKO hearts was observed, which was associated with diminished complex I activity and the onset of mitochondrial oxidative stress. Oxidative damage to stressed mitochondria led to activation of a caspase cascade, with stimulation of caspases 9 and 3 prevented by treatment of 3-month-old TauTKO mice with the mitochondria specific antioxidant, MitoTempo. In 12 month-old, but not 3-month-old, TauTKO hearts, caspase 12 activation contributes to cell death, revealing a pathological role for endoplasmic reticulum (ER) stress in taurine deficient, aging mice. Thus, taurine is a cytoprotective nutrient that ensures normal mitochondrial and ER function, which is important for the reduction of risk for apoptosis and premature death.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Jong CJ,Ito T,Prentice H,Wu JY,Schaffer SWdoi
10.3390/nu9080795subject
Has Abstractpub_date
2017-07-25 00:00:00issue
8issn
2072-6643pii
nu9080795journal_volume
9pub_type
杂志文章相关文献
Nutrients文献大全abstract::N-carbamoyl putrescine (NCP), the decarboxylation derivative of citrulline, metabolically related to polyamines, may exert biological effects in mammals. The aim of this study was (i) to evaluate the nutritional properties of NCP in healthy rats and (ii) to determine the effect of NCP administration on muscle metaboli...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112637
更新日期:2019-11-03 00:00:00
abstract::Different contextual factors of a household and a community, such as access to resources and transportation, may influence the level of food insecurity. The objective of this study was to identify how food environmental factors and economic resources were related to food insecurity in Korean older adults residing in d...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101514
更新日期:2018-10-16 00:00:00
abstract::The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112734
更新日期:2019-11-11 00:00:00
abstract::Physical performance and regeneration after exercise is enhanced by the ingestion of proteins and carbohydrates. These nutrients are generally consumed by athletes via whey protein and glucose-based shakes. In this study, effects of protein and carbohydrate on skeletal muscle regeneration, given either by shake or by ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11040744
更新日期:2019-03-30 00:00:00
abstract::A double-blind, placebo-controlled study was performed in a sample of geriatric patients treated with home enteral nutrition (HEN) to analyze the efficacy of a probiotic supplement Proxian®, which contains Lactiplantibacillus plantarum LP01 (LMG P-21021), Lentilactobacillus buchneri Lb26 (DSM 16341), Bifidobacterium a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13020391
更新日期:2021-01-27 00:00:00
abstract::Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12020435
更新日期:2020-02-08 00:00:00
abstract::Sofrito is a Mediterranean tomato-based sauce that typically also contains olive oil, onion, and garlic. The preparation of sofrito modifies the bioactive compounds (carotenoids and polyphenols) in the ingredients to more bioavailable forms, promoting cis-lycopene formation and polyphenol bioaccessibility. To evaluate...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu11040851
更新日期:2019-04-15 00:00:00
abstract::The purpose of this paper was to determine the foods and beverages offered in the city of Lima, Peru, that would be subject to front-of-package warning labels (octagons) according to the thresholds for the two phases (6 and 39 months after the approval) for nutrients of concern (sugar, sodium, saturated fat, and trans...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051508
更新日期:2020-05-22 00:00:00
abstract::Polygonatum sibiricum (PS) rhizome, which contains glyceryl-1-monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11081719
更新日期:2019-07-25 00:00:00
abstract::To address limited food frequency questionnaire (FFQ) capacity in public health monitoring in Malaysia, we aimed to develop a semi-quantitative FFQ for an adult multiethnic population for comprehensive fatty acid (FA) profiling inclusive of saturated (SFA), monounsaturated (MUFA), polyunsaturated fatty acids (PUFA), P...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010120
更新日期:2020-12-31 00:00:00
abstract:BACKGROUND:With the rapid development of Shanghai's economy, diet habits have undergone great changes. The study aimed to examine the situation of out-of-home (OH) eating in Shanghai adults and the nutrition characteristics of eating in different dining places, and to assess the social demographic determinants of eatin...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10070951
更新日期:2018-07-23 00:00:00
abstract::Poor nutritional status is common among human immunodeficiency virus (HIV)-infected patients including vitamin D (vitD₃) deficiency. We conducted a double-blinded, randomized, and placebo-controlled trial in Addis Ababa, Ethiopia, to investigate if daily nutritional supplementation with vitD₃ (5000 IU) and phenylbutyr...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11010133
更新日期:2019-01-10 00:00:00
abstract::The present study aimed to evaluate the effects of paeoniflorin on insulin resistance and hepatic steatosis induced by fructose. Male Sprague-Dawley rats were fed 20% fructose drink for eight weeks. The insulin sensitivity, serum lipid profiles, and hepatic lipids contents were measured. The results showed that paeoni...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10081024
更新日期:2018-08-05 00:00:00
abstract::Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. This study investigated concentrations of fecal and serum bile acids in 36 vegans and 36 omnivores. The reduced rank regression was used to iden...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010047
更新日期:2019-12-23 00:00:00
abstract::Despite several reports on the relationship between metabolic and neurodegenerative diseases, the effect of a high-sugar diet (HSD) on brain function is still unknown. Given the crucial role of oxidative stress in the pathogenesis of these disorders, this study was the first to compare the effect of an HSD on the acti...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12103181
更新日期:2020-10-18 00:00:00
abstract::The COVID-19 pandemic is having major economic and personal consequences for collegiate and professional sports. Sporting events have been canceled or postponed, and even when baseball and basketball seasons resumed in the United States recently, no fans were in attendance. As play resumed, several players developed C...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123741
更新日期:2020-12-04 00:00:00
abstract::The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, high fat, and high fat...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6104610
更新日期:2014-10-22 00:00:00
abstract::The number of people suffering from constant tinnitus is ever-increasing and has spread to all age groups, including adolescents. The etiology of tinnitus is multifactorial, but dietary factors have been rarely investigated. The purpose of this study is to examine the relationship between dietary factors and constant ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113291
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:prediabetes prevention and management are the main methods used to combat the prevalence of diabetes. Exploratory factor analysis is an upcoming method that is successful in identifying dietary patterns that correlate with healthy or unhealthy outcomes. AIM:this study aims to identify dietary patterns in Ta...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113322
更新日期:2020-10-29 00:00:00
abstract::The indications for delaying the start of dialysis have revived interest in low-protein diets (LPDs). In this observational prospective study, we enrolled all patients with chronic kidney disease (CKD) who followed a moderately restricted LPD in 2007-2015 in a nephrology unit in Italy: 449 patients, 847 years of obser...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8120758
更新日期:2016-11-25 00:00:00
abstract::Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa keeps rising regardless of the emerging cutting-edge technologies for treatment and drug designation. There are a number of treatment options which are effective...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030679
更新日期:2020-03-02 00:00:00
abstract::Vitamin D deficiency is a common issue, particularly in obese populations, and is tested by assessing serum 25(OH)D concentrations. This study aimed to identify factors that contribute to the vitamin D status in fifty morbidly obese individuals recruited prior to bariatric surgery. Data collected included serum 25(OH)...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101094
更新日期:2017-10-04 00:00:00
abstract::The study objectives were to examine total and individual lignan intakes and their dietary sources in postmenopausal Polish women and to investigate the relationship between lignan intake and the prevalence of cardiovascular disease (CVD), hypertension, hypercholesterolemia and central obesity. A total of 2599 postmen...
journal_title:Nutrients
pub_type: 杂志文章,多中心研究
doi:10.3390/nu10070865
更新日期:2018-07-04 00:00:00
abstract:BACKGROUND:Several studies demonstrate that the provision of personalized lifestyle advice, based on genetics, can help motivate individuals to engage in greater nutrition and physical activity changes compared to the provision of population-based advice. The theoretical mechanism behind this phenomenon is poorly under...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123768
更新日期:2020-12-08 00:00:00
abstract::1H NMR spectra were recorded of methanolic extracts of seven soybean varieties (Glycine max.), cultivated using traditional and organic farming techniques. It was possible to identify signals belonging to the groups of amino acids, carbohydrates, organic acids and aromatic substances in the spectra. In the aromatic zo...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu2030280
更新日期:2010-03-01 00:00:00
abstract::Bone problems in the population begin to be establish in childhood. The present study aims to assess the usual calcium, phosphorus, magnesium, and vitamin D intakes, along with the food sources of these nutrients, in Spanish children participating in the EsNuPI (Estudio Nutricional en Población Infantil Española) stud...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061787
更新日期:2020-06-16 00:00:00
abstract::The aim of this paper is to analyze the a priori dietary indexes used in the studies that have evaluated the role of the Mediterranean Diet in influencing the risk of developing cardiovascular disease. All the studies show that this dietary pattern protects against cardiovascular disease, but studies show quite differ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7095367
更新日期:2015-09-16 00:00:00
abstract::This study aimed to investigate the effect of a high-protein diet on growth, body composition, and protein nutritional status of young rats. Newly-weaned Wistar rats, weighing 45-50 g, were distributed in two experimental groups, according to their diets, which contained 12% (G12) or 26% protein (G26), over a period o...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu4091328
更新日期:2012-09-01 00:00:00
abstract::Hypoxia induced by low O2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced me...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123627
更新日期:2020-11-25 00:00:00
abstract::Observational studies have suggested inconsistent findings on the relationship between dairy products intake and endometrial cancer risk. This study aimed to conduct a meta-analysis to evaluate this correlation; moreover, databases including PubMed, ISI Web of Science, and Embase were screened for relevant studies up ...
journal_title:Nutrients
pub_type: 杂志文章,meta分析,评审
doi:10.3390/nu10010025
更新日期:2017-12-28 00:00:00