Abstract：
:The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes is effective in the reduction of allergic symptoms but it cannot be envisioned as a treatment. For the treatment and prevention of IgE-mediated cow's milk allergy, it is thought that the induction of a sustained state of immunological tolerance is needed. In this review, we will discuss various approaches aimed at achieving immunological tolerance and their success. Furthermore, we will speculate on the involved immunological mechanism.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Knol EF,de Jong NW,Ulfman LH,Tiemessen MMdoi
10.3390/nu11112734subject
Has Abstractpub_date
2019-11-11 00:00:00issue
11issn
2072-6643pii
nu11112734journal_volume
11pub_type
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