Abstract:
:Polygonatum sibiricum (PS) rhizome, which contains glyceryl-1-monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals with mild insomnia were enrolled in a four-week, randomized, double-blind, placebo-controlled trial of PS rhizome extract (500 mg/day, n = 40, PS group) or placebo (n = 40, placebo group). The primary outcome measure was change in total score on the Athens Insomnia Scale (AIS) to indicate sleep quality. The secondary outcome measures included change in actigraphy data and perfusion levels in the brain regions within the default mode network (DMN), which is known to play a key role in insomnia. The PS group showed greater improvement in the total AIS score with a significant increase in total sleep time, relative to the placebo group. In addition, significant group-by-visit interactions were observed in the perfusion level of the medial prefrontal cortex within the DMN. Findings of the current study provide first evidence that PS rhizome extract could be an effective natural ingredient for improving sleep in mild insomnia using a human model.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Ha E,Hong H,Kim TD,Hong G,Lee S,Kim S,Kim N,Jeon SD,Ahn CW,Kim HJ,Lee YJ,Yoon S,Kim GH,Kim Jdoi
10.3390/nu11081719subject
Has Abstractpub_date
2019-07-25 00:00:00issue
8issn
2072-6643pii
nu11081719journal_volume
11pub_type
杂志文章,随机对照试验相关文献
Nutrients文献大全abstract::Life-course diet patterns may impact risk of disease, but little is known about dietary trends with aging. In a retrospective longitudinal analysis we estimated lifetime intake of animal products and adherence to vegetarian dietary patterns among 51,082 Adventist Health Study-2 (AHS-2) subjects using data from a relia...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101118
更新日期:2017-10-13 00:00:00
abstract::The objective was to determine effects of feed restriction and refeeding on reproductive development and energy balance in pre-pubertal male rats. Sprague Dawley rats (n = 32, 24 days old, ~65 g), were randomly allocated into four treatments (n = 8/treatment): (1) Control (CON, ad libitum feed; (2) Mild Restriction (M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091993
更新日期:2019-08-23 00:00:00
abstract::Epidemiological studies have provided ambiguous evidence on the association between vitamin E and esophageal cancer risk. To resolve this controversy, we performed this meta-analysis. The literature was searched by using Excerpta Medica Database (EMBASE), PubMed, the Web of Science, and the Cochrane Library from the i...
journal_title:Nutrients
pub_type: 杂志文章,meta分析
doi:10.3390/nu10070801
更新日期:2018-06-21 00:00:00
abstract::Ongoing dietary transitions in the Solomon Islands has resulted in an over-reliance on commercially sourced foods, leading to food insecurity, and a subsequent rise in multiple forms of malnutrition. The aim of this study was to investigate the individual dietary diversity and food preferences of the adult population ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071622
更新日期:2019-07-17 00:00:00
abstract::Low energy availability (EA) (e.g., insufficient energy intake (EI) to match energy needs, including exercise energy expenditure) has been identified as a primary contributor to exercise-associated menstrual dysfunction (ExMD) in active women. For health reasons, active women may self-select diets lower in energy dens...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8040230
更新日期:2016-04-19 00:00:00
abstract::Cherries are known for their nutraceutical properties, in particular for their antioxidant ability due to their polyphenol content, which causes a reduction of cardiovascular disease (CVD) risk factors. However, once ingested these molecules are degraded in the Gastrointestinal (GI) tract before reaching the blood, wh...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111598
更新日期:2018-11-01 00:00:00
abstract::Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80%...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091984
更新日期:2019-08-22 00:00:00
abstract::Little is known about iodine nutritional status in island countries in the Pacific Ocean. The primary objective of this study was to report for the first time the iodine nutritional status of people in Nauru. In addition, sources of iodine nutrition (i.e., water and salt) were investigated. A school-based cross-sectio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8090520
更新日期:2016-08-23 00:00:00
abstract::New Zealand has one of the highest rates of Crohn's Disease (CD) in the world, and there is much speculation as to why this might be. A high risk of CD has been associated with deficient or insufficient levels of Vitamin D (Vit D), lifestyle as well as various genetic polymorphisms. In this study we sought to analyse ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5103898
更新日期:2013-09-27 00:00:00
abstract::Vegetarian diets provide an abundance of nutrients when carefully planned. However, vegetarian diets may have lower protein quality compared to omnivorous diets, a reflection of less favorable amino acid profiles and bioavailability. Hence, the current recommended dietary allowance for protein may not be adequate for ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11123016
更新日期:2019-12-10 00:00:00
abstract::As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10050605
更新日期:2018-05-12 00:00:00
abstract::This cross-sectional study investigated the association between eating alone at each meal and health status, including functional capacity among community-dwelling Japanese elderly living with others. A self-administered questionnaire was mailed to all 8004 residents aged 65 or older, residing in the same Japanese tow...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092805
更新日期:2020-09-13 00:00:00
abstract::Vitamin D (VD) plays an essential role in mineral homeostasis and bone remodeling. A number of different VD-related genes (VDRG) are required for the metabolic activation of VD and the subsequent induction of its target genes. They include a set of genes that encode for VD-binding protein, metabolic enzymes, and the V...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12040962
更新日期:2020-03-30 00:00:00
abstract::G protein-coupled receptor 43/free fatty acid receptor 2 (GPR43/FFAR2) is essential for polymorphonuclear (PMN) recruitment. We investigated the expression of GPR43/FFAR2 in the colon from Crohn's disease patients and whether dietary fiber in enteral nutrition increases GPR43+ polymorphonuclear infiltration in mucosa....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075223
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To investigate dietary habits, sleep and psychological well-being of adolescents and medical students during COVID-19 lockdown in Split, Croatia. METHODS:We surveyed 1326 students during 2018 and 2019, and compared their responses with 531 students enrolled in May 2020. Perceived stress, quality of life (QoL...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010097
更新日期:2020-12-30 00:00:00
abstract::In functional food advertising, messages are not always easily understandable for the target audience. Current European legislation, enforced through Regulation 1924/2006, specifies that such messages should be clear and precise so as not to mislead the consumer. The objective of this study was to observe consumers' u...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113312
更新日期:2020-10-29 00:00:00
abstract::The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concent...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8110696
更新日期:2016-11-04 00:00:00
abstract::Gut microbiota metabolization of dietary choline may promote atherosclerosis through trimethylamine (TMA), which is rapidly absorbed and converted in the liver to proatherogenic trimethylamine-N-oxide (TMAO). The aim of this study was to verify whether TMAO urinary levels may be associated with the fecal relative abun...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010062
更新日期:2019-12-25 00:00:00
abstract::The biologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compare...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041140
更新日期:2020-04-19 00:00:00
abstract::This cross-sectional study addressed the relationship between coffee consumption and periodontitis in patients during the maintenance phase of periodontal treatment. A total of 414 periodontitis patients in the maintenance phase of periodontal treatment completed a questionnaire including items related to coffee intak...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6104476
更新日期:2014-10-21 00:00:00
abstract::Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourtee...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12020430
更新日期:2020-02-07 00:00:00
abstract::Litchi is a tasty fruit that is commercially grown for food consumption and nutritional benefits in various parts of the world. Due to its biological activities, the fruit is becoming increasingly known and deserves attention not only for its edible part, the pulp, but also for its peel and seed that contain beneficia...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9090992
更新日期:2017-09-08 00:00:00
abstract::Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoprote...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10091203
更新日期:2018-09-01 00:00:00
abstract::Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life, morbidity and mortality. Despite the new available criteria, its early diagnosis remains difficult, highlighting the necessity of looking for a valid muscle wasting biomarker. Myostatin, a muscle mass negative regulator, i...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12082401
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Nutritional interventions may have positive effects on sarcopenia and body composition. OBJECTIVE:to evaluate the effectiveness of extra virgin olive oil (EVOO) consumption and a healthy traditional Brazilian diet (DieTBra) on improving sarcopenia indicators and reducing total body fat in severe obesity. M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051498
更新日期:2020-05-21 00:00:00
abstract::The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-r...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051000
更新日期:2019-05-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metaboli...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11092022
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:Observationally, sugar-sweetened beverage (SSB) consumption is associated with adiposity in Western children but could be confounded. We examined the association of SSB frequency with adiposity in the non-Western setting of Hong Kong. METHODS:We examined the associations of SSB consumption frequency at 11 a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041015
更新日期:2020-04-07 00:00:00
abstract::Iodine is a microelement that is naturally present in some foods, added to others, and available as a dietary supplement [...]. ...
journal_title:Nutrients
pub_type: 社论
doi:10.3390/nu12051491
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Polyphenol consumption is implicated in gut microbiome composition and improved metabolic outcomes, but it is unclear whether the effect is independent of dietary fiber. METHODS:We investigated the links between (poly)phenol intake, gut microbiome composition (16s RNA) and obesity independently of fiber int...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061871
更新日期:2020-06-23 00:00:00