Abstract：
:Underlying mechanisms associated with the development of abnormal metabolic phenotypes among obese individuals are not yet clear. Our aim is to investigate differences in plasma metabolomics profiles between normal weight (NW) and overweight/obese (Ov/Ob) individuals, with or without metabolic syndrome (MetS). Mass spectrometry-based metabolite profiling was used to compare metabolite levels between each group. Three main principal components factors explaining a maximum of variance were retained. Factor 1's (long chain glycerophospholipids) metabolite profile score was higher among Ov/Ob with MetS than among Ov/Ob and NW participants without MetS. This factor was positively correlated to plasma total cholesterol (total-C) and triglyceride levels in the three groups, to high density lipoprotein -cholesterol (HDL-C) among participants without MetS. Factor 2 (amino acids and short to long chain acylcarnitine) was positively correlated to HDL-C and negatively correlated with insulin levels among NW participants. Factor 3's (medium chain acylcarnitines) metabolite profile scores were higher among NW participants than among Ov/Ob with or without MetS. Factor 3 was negatively associated with glucose levels among the Ov/Ob with MetS. Factor 1 seems to be associated with a deteriorated metabolic profile that corresponds to obesity, whereas Factors 2 and 3 seem to be rather associated with a healthy metabolic profile.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Allam-Ndoul B,Guénard F,Garneau V,Cormier H,Barbier O,Pérusse L,Vohl MCdoi
10.3390/nu8060324subject
Has Abstractpub_date
2016-05-27 00:00:00issue
6issn
2072-6643pii
nu8060324journal_volume
8pub_type
杂志文章相关文献
Nutrients文献大全abstract：:The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081836
更新日期：2019-08-08 00:00:00
abstract：:Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Coch...
journal_title：Nutrients
pub_type： 杂志文章,meta分析,评审
doi：10.3390/nu8120789
更新日期：2016-12-03 00:00:00
abstract：:High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participating in a populatio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12071940
更新日期：2020-06-30 00:00:00
abstract：:Chronic smokers have a greater risk for altered chemosensation, unhealthy dietary patterns, and excessive adiposity. In an observational study of chronic smokers, we modeled relationships between chemosensation, fat/carbohydrate liking, smoking-associated dietary behaviors, and body mass index (BMI). Also tested in th...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020271
更新日期：2019-01-26 00:00:00
abstract：:Purified glucosylceramide from beet extract (beet GlcCer) and beet extract containing an equal amount of GlcCer were administered orally to ultra violet B (UVB)-irradiated mice, and differences in the protective effects against skin barrier dysfunction caused by UVB irradiation were compared. In the beet GlcCer group,...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9111178
更新日期：2017-10-27 00:00:00
abstract：:Peptides from fish may beneficially affect several metabolic outcomes, including gut health and inflammation. The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, hence this study aimed to evaluate the effect of a cod protein hydrolysate (CPH) supplement on ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11071635
更新日期：2019-07-17 00:00:00
abstract：:People seeking asylum in high-income countries are vulnerable to food insecurity due to limited opportunities for social and economic participation. While charity organizations have long sought to provide food aid to those in need, the increasing number of people seeking this assistance requires alternatives. Using a ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10060756
更新日期：2018-06-12 00:00:00
abstract：:Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10081063
更新日期：2018-08-10 00:00:00
abstract：:A dynamic human gastrointestinal (GI) model was used to digest cooked tubers from purple-fleshed Amachi and Leona potato cultivars to study anthocyanin biotransformation in the stomach, small intestine and colonic vessels. Colonic Caco-2 cancer cells and non-tumorigenic colonic CCD-112CoN cells were tested for cytotox...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu9090953
更新日期：2017-08-29 00:00:00
abstract：:Hypoxia induced by low O2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced me...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123627
更新日期：2020-11-25 00:00:00
abstract：:The association of high vitamin A intake and low bone mineral density (BMD) is still controversial. To determine the association of dietary vitamin A intake and serum 25-hydroxyvitamin D (25(OH)D) concentration with BMD, a total of 6481 subjects (2907 men and 3574 women) aged ≥50 years from the Korean National Health ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7031716
更新日期：2015-03-10 00:00:00
abstract：:This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. METHODS:We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies that reported the r...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12113447
更新日期：2020-11-10 00:00:00
abstract：:Whole grain rice is a rich source of fiber, nutrients, and phytochemicals that may promote gastrointestinal health, but such beneficial components are typically removed with the bran during polishing. Soluble feruloylated arabinoxylan oligosaccharides (FAXO) and polyphenols (RBPP) isolated from rice bran are hypothesi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9111237
更新日期：2017-11-12 00:00:00
abstract：:Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder of carbohydrate maldigestion and malabsorption caused by mutations in the sucrase-isomaltase (SI) gene. SI, together with maltase-glucoamylase (MGAM), belongs to the enzyme family of disaccharidases required for breakdown of -glycosidi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102290
更新日期：2019-09-25 00:00:00
abstract：:Neuroinflammation is pathological evidence of Alzheimer's disease (AD) that likely starts as a host defense response to the damaging effects of the β-amyloid (Aβ) deposits in the brain. The activation of microglia may promote the neurodegenerative process through the release of proinflammatory cytokines, such as inter...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010024
更新日期：2017-01-03 00:00:00
abstract：:The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, high fat, and high fat...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6104610
更新日期：2014-10-22 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is one of the leading causes of offspring malformations, in which eye malformation is an important disease. It has raised demand for therapy to improve fetal outcomes. In this study, we used chick embryo to establish a GDM model to study the protective effects of proanthocyanidins o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085299
更新日期：2015-08-07 00:00:00
abstract：:Vegetarian diets have been associated with atherosclerosis protection, with healthier atherosclerosis risk profiles, as well as lower prevalence of, and mortality from, ischemic heart disease and stroke. However, there are few data concerning the possible cardiovascular effects of a vegan diet (with no meat, dairy or ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6083259
更新日期：2014-08-19 00:00:00
abstract：:Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8060338
更新日期：2016-06-02 00:00:00
abstract：:The aim of the present study was to investigate the effects of Atlantic salmon consumption on underlying biological mechanisms associated with anxiety such as heart rate variability (HRV) and heart rate (HR) as well as a measure of self-reported anxiety. Moreover, these biological and self-reported outcome measures we...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu6125405
更新日期：2014-11-26 00:00:00
abstract：:Selenium (Se) is an essential micronutrient known for its antioxidant properties and health benefits, attributed to its presence in selenoproteins as the amino acid, selenocysteine. Selenocysteine lyase (Scly) catalyzes hydrolysis of selenocysteine to selenide and alanine, facilitating re-utilization of Se for de novo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10020159
更新日期：2018-01-31 00:00:00
abstract：BACKGROUND:The main goal of this study was to assess the acute effects of the intake of 9 and 11 mg/kg/ body mass (b.m.) of caffeine (CAF) on maximal strength and muscle endurance in athletes habituated to caffeine. METHODS:The study included 16 healthy strength-trained male athletes (age = 24.2 ± 4.2 years, body mass...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11081912
更新日期：2019-08-15 00:00:00
abstract：:This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case⁻control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies wit...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040750
更新日期：2019-03-30 00:00:00
abstract：:Even though irritable bowel syndrome (IBS) has been known for more than 150 years, it still remains one of the research challenges of the 21st century. According to the current diagnostic Rome IV criteria, IBS is characterized by abdominal pain associated with defecation and/or a change in bowel habit, in the absence ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092162
更新日期：2019-09-09 00:00:00
abstract：:Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin res...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085283
更新日期：2015-08-04 00:00:00
abstract：:Health care-induced diseases constitute a fast-increasing problem. Just one type of these health care-associated infections (HCAI) constitutes the fourth leading cause of death in Western countries. About 25 million individuals worldwide are estimated each year to undergo major surgery, of which approximately 3 millio...
journal_title：Nutrients
pub_type： 历史文章,杂志文章,评审
doi：10.3390/nu5010162
更新日期：2013-01-14 00:00:00
abstract：:Marine n-3 polyunsaturated fatty acids (PUFA) may improve autonomic dysfunction, as indicated by an increase in heart rate variability (HRV) and reduce the risk of sudden cardiac death. Hence, the aim of this study was to investigate the effects of marine n-3 PUFA on 24-h HRV in patients on chronic dialysis, who have ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10091313
更新日期：2018-09-17 00:00:00
abstract：:Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091981
更新日期：2019-08-22 00:00:00
abstract：:Stimulation of the ubiquitin-proteasome pathway-especially E3 ubiquitin ligases Atrogin-1 and MuRF1-is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091040
更新日期：2017-09-20 00:00:00
abstract：:Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status. For this reason, we decided to analyze circulating SELENBP1 concentrations in patients ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092005
更新日期：2019-08-25 00:00:00
