Abstract：
:Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Yang J,Fernández-Galilea M,Martínez-Fernández L,González-Muniesa P,Pérez-Chávez A,Martínez JA,Moreno-Aliaga MJdoi
10.3390/nu11040872subject
Has Abstractpub_date
2019-04-18 00:00:00issue
4issn
2072-6643pii
nu11040872journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Vitamin D status has been implicated in obesity and adipose tissue inflammation. In the present study, we explored the effects of dietary vitamin D supplementation on adipose tissue inflammation and immune cell population, and the effects of in vitro 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) treatment on pro-inflammator...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020364
更新日期：2020-01-30 00:00:00
abstract：:Copper, which can potentially be a highly toxic agent, is an essential nutrient due to its role as a cofactor for cuproenzymes and its participation in signaling pathways. In mammals, the liver is a central organ that controls copper turnover throughout the body, including copper absorption, distribution, and excretio...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10111591
更新日期：2018-10-30 00:00:00
abstract：:Dysmagnesemia is a serious disturbance of microelement homeostasis. The aim of this study was to analyze the distribution of serum magnesium concentrations in hospitalized patients according to gender, age, and result of hospitalization. The study was conducted from February 2018 to January 2019 at the Central Clinica...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061836
更新日期：2020-06-19 00:00:00
abstract：:Recent studies have demonstrated that wheat peptides protected rats against non-steroidal anti-inflammatory drugs-induced small intestinal epithelial cells damage, but the mechanism of action is unclear. In the present study, an indomethacin-induced oxidative stress model was used to investigate the effect of wheat pe...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6020564
更新日期：2014-01-29 00:00:00
abstract：:Hot water was used to obtain Chlorella sorokiniana hot water extract (HWE). Subsequently, this byproduct was freeze-dried, hydrolysed at 50 °C using Protease N to obtain C. sorokiniana protein hydrolysates (PN-1), and then digested with a gastrointestinal enzyme (PN-1G). The inhibitory effects of the HWE and hydrolysa...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101397
更新日期：2018-10-01 00:00:00
abstract：:In adults, fermentation of high amylose maize starch (HAMS), a resistant starch (RS), has a prebiotic effect. Were such a capacity to exist in infants, intake of RS might programme the gut microbiota during a critical developmental period. This study aimed to determine if infant faecal inocula possess the capacity to ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061345
更新日期：2019-06-14 00:00:00
abstract：:Randomized controlled trials on diet and shortening of leukocyte telomere length (LTL) mostly focus on marine-derived n-3 polyunsaturated fatty acids (PUFA). Walnuts are a sustainable source of n-3 PUFA. We investigated whether inclusion of walnuts (15% of energy) in the diet for 2 years would maintain LTL in cognitiv...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10121907
更新日期：2018-12-04 00:00:00
abstract：:Nutrient timing involves manipulation of nutrient consumption at specific times in and around exercise bouts in an effort to improve performance, recovery, and adaptation. Its historical perspective centered on ingestion during exercise and grew to include pre- and post-training periods. As research continued, transla...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12071948
更新日期：2020-06-30 00:00:00
abstract：UNLABELLED:Reduced physical activity and almost unlimited availability of food are major contributors to the development of obesity. With the decline of strenuous work, energy expenditure due to spontaneous physical activity has attracted increasing attention. Our aim was to assess changes in energy expenditure, physic...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7075256
更新日期：2015-07-16 00:00:00
abstract：:Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer's disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7105391
更新日期：2015-09-24 00:00:00
abstract：:Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091967
更新日期：2019-08-21 00:00:00
abstract：:Vitamin A is essential for growth and development. We investigated whether high consumption of energy-dense nutrient-poor foods in the diets of pre-school children is detrimental to diet quality with respect to vitamin A. Data were collected from 755 children at 18-months and 3½-years, from the Avon Longitudinal Study...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5051609
更新日期：2013-05-15 00:00:00
abstract：:Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10081063
更新日期：2018-08-10 00:00:00
abstract：:The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of bot...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030862
更新日期：2020-03-24 00:00:00
abstract：:The aim of the present study was to report the usual nutrient intakes of sixteen micronutrients by schoolchildren, adults and the elderly in Greece and to further explore the role of age, sex and socio-economic status (SES) on meeting the recommended nutrient intakes. Dietary intake, demographic and SES data from thre...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6104073
更新日期：2014-10-03 00:00:00
abstract：:Exercise has beneficial effects on our health by stimulating metabolic activation of skeletal muscle contraction. Caffeine is a powerful metabolic stimulant in the skeletal muscle that has ergogenic effects, including enhanced muscle power output and endurance capacity. In the present study, we aim to characterize the...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081819
更新日期：2019-08-07 00:00:00
abstract：BACKGROUND:Fluid overload and protein-energy wasting (PEW) are common in patients with end-stage renal disease (ESRD) and lead to a poor prognosis. We aimed to evaluate the volume and nutritional status of ESRD patients and to determine the clinical significance of phase angle (PhA). METHODS:This study was a cross-sec...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091331
更新日期：2018-09-19 00:00:00
abstract：:The objective of this study was to determine the top frequently reported foods or beverages and the top foods or beverages grouped by broad and specific What We Eat In America (WWEIA) categories for adult age groups of 19 to 35 years, 36 to 55 years, and ≥65 years (n = 16,399) using data drawn from the cross-sectional...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010086
更新日期：2017-01-23 00:00:00
abstract：:Stimulation of the ubiquitin-proteasome pathway-especially E3 ubiquitin ligases Atrogin-1 and MuRF1-is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091040
更新日期：2017-09-20 00:00:00
abstract：:The methodology used in dietary surveys could, to a large extent, follow the instructions of the European Food Safety Authority (EFSA), where 24-h dietary recall (24HDR) is recommended for (sub) population studies. However, it is necessary to examine the suitability of 24HDR for indicative dietary intake in older adul...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092234
更新日期：2019-09-16 00:00:00
abstract：:The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11112734
更新日期：2019-11-11 00:00:00
abstract：:This study sought to describe and compare adherence to the Mediterranean diet and consumption of local foods from the Huelva region among Spanish university women in relation to menstrual pain and other menstrual characteristics. This cross-sectional study included 311 health science students. The study variables were...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061759
更新日期：2020-06-12 00:00:00
abstract：:This cross-sectional study is aimed at assessing sodium (Na) and potassium (K) content and the molar Na:K ratios of the most commonly available ready-to-eat street foods in Tajikistan and Kyrgyzstan. Four different samples of each of these foods were collected and 62 food categories were evaluated through bromatologic...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010098
更新日期：2018-01-16 00:00:00
abstract：:Discrepancies exist among food processing classification systems and in the relationship between processed food intake and dietary quality of children. This study compared inter-rater reliability, food processing category, and the relationship between processing category and nutrient concentration among three systems ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061344
更新日期：2019-06-14 00:00:00
abstract：:This study evaluated the effect of linseed incorporation in laying hens' feed (alone or along with a tomato-red pepper mix) on laying hens' egg yolk fatty acids profile, as well as on their atherogenic (IA) and thrombogenic (IT) health lipid indexes, and the ratio between the hypocholesterolemic and hypercholesterolem...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040813
更新日期：2019-04-10 00:00:00
abstract：:The association between milk intake and cognitive disorders has been investigated in several epidemiological studies, but the findings are still conflicting. No quantitative assessment has been performed to evaluate the potential relationship of milk intake and cognitive disorders. From the inception to October 2016, ...
journal_title：Nutrients
pub_type： 杂志文章,meta分析,评审
doi：10.3390/nu8120824
更新日期：2016-12-20 00:00:00
abstract：:The Editorial Office of Nutrients would like to report an error in the published paper [1] [...]. ...
journal_title：Nutrients
pub_type： 杂志文章,已发布勘误
doi：10.3390/nu10040467
更新日期：2018-04-10 00:00:00
abstract：:Clean eating is understood in broad terms to be an approach to eating which promotes the exclusion of processed foods. Social media and websites which promote clean eating are becoming increasingly popular as sources of nutrition information. Currently, there is a lack of knowledge regarding women's opinions about cle...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091266
更新日期：2018-09-08 00:00:00
abstract：:Cow's milk allergy (CMA) is an early-onset allergy of which the underlying genetic factors remain largely undiscovered. CMA has been found to co-occur with other allergies and immunological hypersensitivity disorders, suggesting a shared genetic etiology. We aimed to (1) investigate and (2) validate whether CMA childr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111582
更新日期：2018-10-27 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) pandemic resulted in physical isolation measures in many parts of the world. In Australia, nationwide restrictions included staying at home, unless seeking medical care, providing care, purchasing food, undertaking exercise, or attending work in an essential service. All undergr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061865
更新日期：2020-06-23 00:00:00
