当前位置： SCI文献检索 > Nutrients期刊下所有文献 > Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner.

Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner.

Abstract：

:Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm infants. Formula feeding is a risk factor for NEC and osmolality, which is increased by the fortification that is required for adequate growth of the infant, has been suggested as a potential cause. Our laboratory has shown that Paneth cell disruption followed by induction of dysbiosis can induce NEC-like pathology in the absence of feeds. We hypothesized adding formula feeds to the model would exacerbate intestinal injury and inflammation in an osmolality-dependent manner. NEC-like injury was induced in 14-16 day-old C57Bl/6J mice by Paneth cell disruption with dithizone or diphtheria toxin, followed by feeding rodent milk substitute with varying osmolality (250-1491 mOsm/kg H2O). Animal weight, serum cytokines and osmolality, small intestinal injury, and cecal microbial composition were quantified. Paneth cell-disrupted mice fed formula had significant NEC scores compared to controls and no longer required induction of bacterial dysbiosis. Significant increases in serum inflammatory markers, small intestinal damage, and overall mortality were osmolality-dependent and not related to microbial changes. Overall, formula feeding in combination with Paneth cell disruption induced NEC-like injury in an osmolality-dependent manner, emphasizing the importance of vigilance in designing preterm infant feeds.

journal_name

Nutrients

journal_title

Nutrients

authors

Lueschow SR,Kern SL,Gong H,Grobe JL,Segar JL,Carlson SJ,McElroy SJ

doi

10.3390/nu12040900

subject

Has Abstract

pub_date

2020-03-26 00:00:00

issue

4

issn

2072-6643

pii

nu12040900

journal_volume

12

pub_type

杂志文章

相关文献

Nutrients文献大全
  • Food Composition Impacts the Accuracy of Wearable Devices When Estimating Energy Intake from Energy-Dense Food.

    abstract：:The present study aimed to assess the feasibility and reliability of an a3utomatic food intake measurement device in estimating energy intake from energy-dense foods. Eighteen volunteers aged 20-36 years were recruited from the University of Padova. The device used in the present study was the Bite Counter (Bite Techn...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11051170

    authors： Lorenzoni G,Bottigliengo D,Azzolina D,Gregori D

    更新日期：2019-05-24 00:00:00

  • Development of Criteria for a Positive Front-of-Package Food Labeling: The Israeli Case.

    abstract：:Efforts to shape the food environment are aimed at reducing diet-related co-morbidities. Front-of-package labeling (FOPL) may support the consumers to make an informed decision at the point of purchase and encourage industry to reformulate food products. The Israeli Ministry of Health (MOH) implemented a unique FOPL s...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12061875

    authors： Gillon-Keren M,Kaufman-Shriqui V,Goldsmith R,Safra C,Shai I,Fayman G,Berry E,Tirosh A,Dicker D,Froy O,Gordon E,Chavia Ben-Yosef AC,Nitsan L,Altman H,Blaychfeld-Magnazi M,Endevelt R

    更新日期：2020-06-23 00:00:00

  • The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.

    abstract：:Background: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051313

    authors： Macher S,Herster C,Holter M,Moritz M,Matzhold EM,Stojakovic T,Pieber TR,Schlenke P,Drexler C,Amrein K

    更新日期：2020-05-05 00:00:00

  • Multi-Grain Rice Diet Decreases Risk of Breast Cancer in Korean Women: Results from the Health Examinees Study.

    abstract：:Although a number of studies explain the association between dietary patterns, which take into account that foods are eaten in combination, and breast cancer risk, the findings are inconsistent. We examined the association between dietary patterns and multi-grain rice intake, and the risk of breast cancer in a large-s...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12082273

    authors： Shin WK,Lee HW,Shin A,Lee JK,Lee SA,Lee JE,Kang D

    更新日期：2020-07-29 00:00:00

  • An Audit of Australian Bread with a Focus on Loaf Breads and Whole Grain.

    abstract：:Bread is a vehicle for a range of nutrients within the Australian diet, but has been the target of negative press. The aim of this study was to examine bread products, particularly white, whole grain and gluten-free loaves, including nutrients, health claims and Health Star Rating (HSR). An audit of four supermarkets ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10081106

    authors： Grafenauer S,Curtain F

    更新日期：2018-08-16 00:00:00

  • Caregiver's Self-Confidence in Food Resource Management Is Associated with Lower Risk of Household Food Insecurity among SNAP-Ed-Eligible Head Start Families.

    abstract：:Food resource management (FRM) behaviors are key components within nutrition education programs designed to help food insecure households maximize their food dollars. However, little is known about the association between FRM self-confidence and financial practices with household food insecurity (HFI) among families w...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12082304

    authors： Jomaa L,Na M,Eagleton SG,Diab-El-Harake M,Savage JS

    更新日期：2020-07-31 00:00:00

  • Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial.

    abstract：:Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 time...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu11092126

    authors： Hibi M,Hari S,Yamaguchi T,Mitsui Y,Kondo S,Katashima M

    更新日期：2019-09-06 00:00:00

  • Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project.

    abstract：:As malnutrition is common in patients with Alzheimer's disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11051161

    authors： Doorduijn AS,Visser M,van de Rest O,Kester MI,de Leeuw FA,Boesveldt S,Fieldhouse JLP,van den Heuvel EGHM,Teunissen CE,Scheltens P,van der Flier WM,de van der Schueren MAE

    更新日期：2019-05-23 00:00:00

  • Adults and Children in Low-Income Households that Participate in Cost-Offset Community Supported Agriculture Have High Fruit and Vegetable Consumption.

    abstract：:This paper examines fruit and vegetable intake (FVI) in low-income households that participated in a cost-offset (CO), or 50% subsidized, community-supported agriculture (CSA) program. CSA customers paid farms upfront for a share of the harvest, and received produce weekly throughout the growing season. A cohort of ad...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9070726

    authors： Hanson KL,Kolodinsky J,Wang W,Morgan EH,Pitts SBJ,Ammerman AS,Sitaker M,Seguin RA

    更新日期：2017-07-08 00:00:00

  • Human Milk Casein and Whey Protein and Infant Body Composition over the First 12 Months of Lactation.

    abstract：:Human milk (HM) influences infant feeding patterns and body composition (BC). This small proof-of concept longitudinal study investigated relationships between infant/maternal BC and HM casein, whey and total protein during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured at 2 (n = 15)...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10091332

    authors： Gridneva Z,Tie WJ,Rea A,Lai CT,Ward LC,Murray K,Hartmann PE,Geddes DT

    更新日期：2018-09-19 00:00:00

  • The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders.

    abstract：:Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural compone...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11040769

    authors： Ciappolino V,Mazzocchi A,Botturi A,Turolo S,Delvecchio G,Agostoni C,Brambilla P

    更新日期：2019-04-02 00:00:00

  • A Single Day of Excessive Dietary Fat Intake Reduces Whole-Body Insulin Sensitivity: The Metabolic Consequence of Binge Eating.

    abstract：:Consuming excessive amounts of energy as dietary fat for several days or weeks can impair glycemic control and reduce insulin sensitivity in healthy adults. However, individuals who demonstrate binge eating behavior overconsume for much shorter periods of time; the metabolic consequences of such behavior remain unknow...

    journal_title：Nutrients

    pub_type： 临床试验,杂志文章

    doi：10.3390/nu9080818

    authors： Parry SA,Woods RM,Hodson L,Hulston CJ

    更新日期：2017-07-29 00:00:00

  • EEN Yesterday and Today … CDED Today and Tomorrow.

    abstract：:The treatment of Pediatric Crohn's Disease (CD) requires attention both to achieve mucosal healing and to optimize growth, while also maintaining proper bone health. Exclusive Enteral Nutrition (EEN) is recommended as first-line treatment in luminal CD. The therapeutic mechanisms of EEN are being discovered by advance...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12123793

    authors： Herrador-López M,Martín-Masot R,Navas-López VM

    更新日期：2020-12-10 00:00:00

  • Sugar Content in Processed Foods in Spain and a Comparison of Mandatory Nutrition Labelling and Laboratory Values.

    abstract：:To reduce the sugar content of processed foods through reformulation, the first step is to determine the content of the largest sources of sugars in each country's diet. The aim of this work was to describe the sugar content in the most commonly consumed processed foods in Spain and to compare that sugar's labelling a...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12041078

    authors： Yusta-Boyo MJ,Bermejo LM,García-Solano M,López-Sobaler AM,Ortega RM,García-Pérez M,Dal-Re Saavedra MÁ

    更新日期：2020-04-13 00:00:00

  • Fatty Acid Desaturase Involvement in Non-Alcoholic Fatty Liver Disease Rat Models: Oxidative Stress Versus Metalloproteinases.

    abstract：:We investigated changes in fatty acid desaturases, D5D, D6D, D9-16D and D9-18D, and their relationship with oxidative stress, matrix metalloproteinases (MMPs) and serum TNF-alpha in two rat models of non-alcoholic fatty liver disease NAFLD. Eight-week-old male Wistar rats fed for 3 weeks with methionine-choline⁻defici...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11040799

    authors： Palladini G,Di Pasqua LG,Berardo C,Siciliano V,Richelmi P,Mannucci B,Croce AC,Rizzo V,Perlini S,Vairetti M,Ferrigno A

    更新日期：2019-04-08 00:00:00

  • Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review.

    abstract：:This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. METHODS:We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies that reported the r...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12113447

    authors： Gonçalves C,Abreu S

    更新日期：2020-11-10 00:00:00

  • Bone Mineral Density, Mechanical, Microstructural Properties and Mineral Content of the Femur in Growing Rats Fed with Cactus Opuntia ficus indica (L.) Mill. (Cactaceae) Cladodes as Calcium Source in Diet.

    abstract：:Mechanical, microstructural properties, mineral content and bone mineral density (BMD) of the femur were evaluated in growing rats fed with Opuntia ficus indica (L.) Mill. (Cactaceae) cladodes at different maturity stages as calcium source. Male weanling rats were fed with cladodes at early maturity stage (25 and 60 d...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9020108

    authors： Hernández-Becerra E,Gutiérrez-Cortez E,Del Real A,Rojas-Molina A,Rodríguez-García M,Rubio E,Quintero-García M,Rojas-Molina I

    更新日期：2017-02-04 00:00:00

  • Chyme Reinfusion in Intestinal Failure Related to Temporary Double Enterostomies and Enteroatmospheric Fistulas.

    abstract：:Some temporary double enterostomies (DES) or entero-atmospheric fistulas (EAF) have high output and are responsible for Type 2 intestinal failure. Intravenous supplementations (IVS) for parenteral nutrition and hydration compensate for intestinal losses. Chyme reinfusion (CR) artificially restores continuity pending s...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051376

    authors： Picot D,Layec S,Seynhaeve E,Dussaulx L,Trivin F,Carsin-Mahe M

    更新日期：2020-05-11 00:00:00

  • Changes in Fatty Acid Composition of Human Milk in Response to Cold-Like Symptoms in the Lactating Mother and Infant.

    abstract：:Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9091034

    authors： Gardner AS,Rahman IA,Lai CT,Hepworth A,Trengove N,Hartmann PE,Geddes DT

    更新日期：2017-09-19 00:00:00

  • Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats.

    abstract：:Tocotrienols have been reported to improve lipid profiles, reduce atherosclerotic lesions, decrease blood glucose and glycated haemoglobin concentrations, normalise blood pressure in vivo and inhibit adipogenesis in vitro, yet their role in the metabolic syndrome has not been investigated. In this study, we investigat...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu4101527

    authors： Wong WY,Poudyal H,Ward LC,Brown L

    更新日期：2012-10-22 00:00:00

  • Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review.

    abstract：:The search for a quality diet has grown over the past decade. Diet is considered one of the pillars for the prevention and progression of several diseases, among them: diabetes. Type 2 diabetes (T2D) is an epidemic of western countries that increases the vulnerability of other diseases, such as cardiovascular and canc...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12082236

    authors： Martín-Peláez S,Fito M,Castaner O

    更新日期：2020-07-27 00:00:00

  • Are Edentulousness, Oral Health Problems and Poor Health-Related Quality of Life Associated with Malnutrition in Community-Dwelling Elderly (Aged 75 Years and Over)? A Cross-Sectional Study.

    abstract：:As the population ages, the risk of becoming malnourished increases. Research has shown that poor oral health can be a risk factor for malnutrition in institutionalized elderly. However, it remains unclear whether oral health problems, edentulousness and health-related quality of life also pose a risk for malnutrition...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10121965

    authors： Bakker MH,Vissink A,Spoorenberg SLW,Jager-Wittenaar H,Wynia K,Visser A

    更新日期：2018-12-12 00:00:00

  • Evaluating Nutrient-Based Indices against Food- and Diet-Based Indices to Assess the Health Potential of Foods: How Does the Australian Health Star Rating System Perform after Five Years?

    abstract：:Nutrient-based indices are commonly used to assess the health potential of individual foods for nutrition policy actions. This study aimed to evaluate the nutrient profile-informed Australian Health Star Rating (HSR), against NOVA and an index informed by the Australian Dietary Guidelines (ADGs), to determine the exte...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051463

    authors： Dickie S,Woods JL,Baker P,Elizabeth L,Lawrence MA

    更新日期：2020-05-18 00:00:00

  • Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort.

    abstract：:Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. W...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu7115457

    authors： Eguaras S,Toledo E,Hernández-Hernández A,Cervantes S,Martínez-González MA

    更新日期：2015-11-05 00:00:00

  • Mediterranean diet pyramid: a proposal for Italian people.

    abstract：:Bread was a staple in the traditional Mediterranean diet of the early 1960s, as well as nowadays; however, it was a stone ground sourdough bread in Nicotera and probably in the Greek cohorts of the Seven Countries Study. In the present review, the nutritional characteristics of this food are analyzed in relation to it...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu6104302

    authors： D'Alessandro A,De Pergola G

    更新日期：2014-10-16 00:00:00

  • Effects of Rapid Weight Loss on Judo Athletes: A Systematic Review.

    abstract：:Rapid weight loss (RWL) is commonly practiced among judo athletes. Although it helps them to gain the advantage over their lighter opponents, previous studies have shown that RWL can have a negative impact on the athlete's performance and overall well-being. This systematic review aimed to synthesize the evidence that...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12051220

    authors： Lakicevic N,Roklicer R,Bianco A,Mani D,Paoli A,Trivic T,Ostojic SM,Milovancev A,Maksimovic N,Drid P

    更新日期：2020-04-26 00:00:00

  • Associations of Food Outlet Densities with Obesity Measures Identify Fish and Chip Shops as a Uniquely Important Problem.

    abstract：:Increases in the number of food outlets have been proposed as a key factor driving obesity. This study aimed to investigate the association between the densities of food establishments serving meals (excluding supermarkets and grocery stores), with body mass index (BMI), waist to hip ratio (WHR) and percentage of body...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12040890

    authors： Albalawi A,Hambly C,Speakman J

    更新日期：2020-03-25 00:00:00

  • Analysis of Sport Supplement Consumption and Body Composition in Spanish Elite Rowers.

    abstract：:The aim of this study was to analyze the anthropometric characteristics and sport supplement (SS) consumption patterns of heavyweight and lightweight international rowers. Methods: The 13 heavyweights (11 males) and seven lightweights (five males) of the Spanish National Rowing Team were recruited for the study. Body ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12123871

    authors： Domínguez R,López-Domínguez R,López-Samanes Á,Gené P,González-Jurado JA,Sánchez-Oliver AJ

    更新日期：2020-12-18 00:00:00

  • Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities.

    abstract：:Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic eleme...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11020328

    authors： Kocylowski R,Grzesiak M,Gaj Z,Lorenc W,Bakinowska E,Barałkiewicz D,von Kaisenberg CS,Lamers Y,Suliburska J

    更新日期：2019-02-03 00:00:00

  • Flavonoid Intake and Plasma Sex Steroid Hormones, Prolactin, and Sex Hormone-Binding Globulin in Premenopausal Women.

    abstract：BACKGROUND:Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. OBJECTIVE:To examine the relationship bet...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11112669

    authors： Wu Y,Hankinson SE,Smith-Warner SA,Wang M,Eliassen AH

    更新日期：2019-11-05 00:00:00