当前位置： SCI文献检索 > Nutrients期刊下所有文献 > Intravenous Arginine Administration Benefits CD4+ T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis.

Intravenous Arginine Administration Benefits CD4+ T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis.

Abstract：

:This study investigated the effects of a single dose of arginine (Arg) administration at the beginning of sepsis on CD4+ T-cell regulation and liver inflammation in C57BL/6J mice. Mice were divided into normal control (NC), sham (SH), sepsis saline (SS), and sepsis Arg (SA) groups. An inducible nitric oxide (NO) synthase (iNOS) inhibitor was administered to additional sepsis groups to evaluate the role of NO during sepsis. Sepsis was induced using cecal ligation and puncture (CLP). The SS and SA groups received saline or Arg (300 mg/kg body weight) via tail vein 1 h after CLP. Mice were euthanized at 12 and 24 h post-CLP. Blood, para-aortic lymph nodes, and liver tissues were collected for further measurement. The findings showed that sepsis resulted in decreases in blood and para-aortic lymph node CD4+ T-cell percentages, whereas percentages of interleukin (IL)-4- and IL-17-expressing CD4+ T cells were upregulated. Compared to the SS group, Arg administration resulted in maintained circulating and para-aortic lymph node CD4+ T cells, an increased Th1/Th2 ratio, and a reduced Th17/Treg ratio post-CLP. In addition, levels of plasma liver injury markers and expression of inflammatory genes in liver decreased. These results suggest that a single dose of Arg administered after CLP increased Arg availability, sustained CD4+ T-cell populations, elicited more-balanced Th1/Th2/Th17/Treg polarization in the circulation and the para-aortic lymph nodes, and attenuated liver inflammation in sepsis. The favorable effects of Arg were abrogated when an iNOS inhibitor was administered, which indicated that NO may be participated in regulating the homeostasis of Th/Treg cells and subsequent liver inflammation during sepsis.

journal_name

Nutrients

journal_title

Nutrients

authors

Yeh CL,Tanuseputero SA,Wu JM,Tseng YR,Yang PJ,Lee PC,Yeh SL,Lin MT

doi

10.3390/nu12041047

subject

Has Abstract

pub_date

2020-04-10 00:00:00

issue

4

issn

2072-6643

pii

nu12041047

journal_volume

12

pub_type

杂志文章

相关文献

Nutrients文献大全
  • Gluten-Free Diet: Gaps and Needs for a Healthier Diet.

    abstract：:The gluten-free diet (GFD) is currently the only effective treatment in remitting the symptoms of coeliac disease (CD), a chronic systemic autoimmune disorder caused by a permanent intolerance to gluten proteins in genetically susceptible individuals. The diet entails the substitution of gluten-containing products wit...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11010170

    authors： Melini V,Melini F

    更新日期：2019-01-15 00:00:00

  • Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats.

    abstract：:Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in met...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9040323

    authors： Cioffi F,Senese R,Lasala P,Ziello A,Mazzoli A,Crescenzo R,Liverini G,Lanni A,Goglia F,Iossa S

    更新日期：2017-03-24 00:00:00

  • Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy.

    abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementa...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu7125498

    authors： Rybalka E,Timpani CA,Stathis CG,Hayes A,Cooke MB

    更新日期：2015-11-26 00:00:00

  • The Evolving Role of Multivitamin/Multimineral Supplement Use among Adults in the Age of Personalized Nutrition.

    abstract：:Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. T...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu10020248

    authors： Blumberg JB,Bailey RL,Sesso HD,Ulrich CM

    更新日期：2018-02-22 00:00:00

  • Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions.

    abstract：:Accumulated evidence suggests that the cruciferous vegetables-derived compound indole-3-carbinol (I3C) may protect against prostate cancer, but the precise mechanisms underlying its action remain unclear. This study aimed to verify the hypothesis that the beneficial effect of dietary I3C may be due to its modulatory e...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11020467

    authors： Wu Y,Li RW,Huang H,Fletcher A,Yu L,Pham Q,Yu L,He Q,Wang TTY

    更新日期：2019-02-22 00:00:00

  • Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2.

    abstract：:Vitamin C supplementation has been shown to decrease triple-negative breast cancer (TNBC) metastasis. However, the molecular mechanism whereby vitamin C inhibits metastasis remains elusive. It has been postulated that vitamin C reduces the levels of HIF-1α, the master regulator of metastasis, by promoting its hydroxyl...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11122997

    authors： Gan L,Camarena V,Mustafi S,Wang G

    更新日期：2019-12-06 00:00:00

  • Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia.

    abstract：:Postprandial plasma glucose and triglyceride concentrations are predictive of relative cardiovascular disease (CVD) risk, and the pathogenesis of both insulin resistance and atherosclerosis has been attributed to acute states of hyperglycemia and hypertriglyceridemia. Postprandial lipemia and hyperglycemia suppress va...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12123806

    authors： Leary M,Tanaka H

    更新日期：2020-12-11 00:00:00

  • Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice.

    abstract：:Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and pos...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12061777

    authors： Dinel AL,Lucas C,Guillemet D,Layé S,Pallet V,Joffre C

    更新日期：2020-06-15 00:00:00

  • Diet Quality and Nutrient Intake of Urban Overweight and Obese Primarily African American Older Adults with Osteoarthritis.

    abstract：:Diet quality may be a unique target for preventing and managing obesity-related osteoarthritis (OA). Using the Healthy Eating Index-2010 (HEI-2010), this study examined the nutrient intake and diet quality of 400 urban overweight and obese primarily African American older adults with self-reported lower extremity OA. ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10040485

    authors： Vergis S,Schiffer L,White T,McLeod A,Khudeira N,Demott A,Fitzgibbon M,Hughes S,Tussing-Humphreys L

    更新日期：2018-04-13 00:00:00

  • Changes in Fatty Acid Composition of Human Milk in Response to Cold-Like Symptoms in the Lactating Mother and Infant.

    abstract：:Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9091034

    authors： Gardner AS,Rahman IA,Lai CT,Hepworth A,Trengove N,Hartmann PE,Geddes DT

    更新日期：2017-09-19 00:00:00

  • Zinc Content in Breast Milk and Its Association with Maternal Diet.

    abstract：BACKGROUND:Zinc is an indispensable element, being involved in many biological processes. Correspondingly, insufficient zinc intake in early youth can detrimentally affect the function of a growing body. The aim of this study was to determine zinc content in breast milk among lactating women in Latvia and factors (mate...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10101438

    authors： Aumeistere L,Ciproviča I,Zavadska D,Bavrins K,Borisova A

    更新日期：2018-10-05 00:00:00

  • Trends in Food Consumption Patterns of US Infants and Toddlers from Feeding Infants and Toddlers Studies (FITS) in 2002, 2008, 2016.

    abstract：:The Feeding Infants and Toddlers Study (FITS) is the largest survey of dietary intake among infants and young children in the United States. Dietary patterns in early childhood are a key component of prevention of diet-related chronic diseases, yet little is known about how food consumption patterns of infants and you...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11112807

    authors： Duffy EW,Kay MC,Jacquier E,Catellier D,Hampton J,Anater AS,Story M

    更新日期：2019-11-17 00:00:00

  • Therapeutic effect of polysaccharide of large yellow croaker swim bladder on lupus nephritis of mice.

    abstract：:The therapeutic effect of polysaccharide of large yellow croaker swim bladder (PLYCSB) on lupus nephritis has been studied in vivo. A high concentration (50 mg/kg dose) of PLYCSB reduced the levels of serum inflammatory cytokine levels of IL-6, IL-12, TNF-α and IFN-γ compared to a low concentration (25 mg/kg dose) and...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu6031223

    authors： Jiang X,Zhao X,Luo H,Zhu K

    更新日期：2014-03-24 00:00:00

  • Survival and Nutritional Status of Male and Female Heart Transplant Patients Based on the Nutritional Risk Index.

    abstract：:Malnutrition among heart-transplant patients may affect survival. The aim was to investigate the survival and nutrition status among male and female heart transplant patients who underwent transplantation, before and 1 year after surgery based on the nutritional risk index (NRI). The medical records of ninety heart-tr...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12123868

    authors： Almutawa DA,Almuammar M,Elshafie MM,Aljuraiban GS,Alnafisah A,Abulmeaty MMA

    更新日期：2020-12-17 00:00:00

  • The Effects of High Doses of Caffeine on Maximal Strength and Muscular Endurance in Athletes Habituated to Caffeine.

    abstract：BACKGROUND:The main goal of this study was to assess the acute effects of the intake of 9 and 11 mg/kg/ body mass (b.m.) of caffeine (CAF) on maximal strength and muscle endurance in athletes habituated to caffeine. METHODS:The study included 16 healthy strength-trained male athletes (age = 24.2 ± 4.2 years, body mass...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu11081912

    authors： Wilk M,Krzysztofik M,Filip A,Zajac A,Del Coso J

    更新日期：2019-08-15 00:00:00

  • 25-Hydroxy-Vitamin D Concentration Is Not Affected by Severe or Non-Severe Pneumonia, or Inflammation, in Young Children.

    abstract：:Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9010052

    authors： Haugen J,Chandyo RK,Ulak M,Mathisen M,Basnet S,Brokstad KA,Valentiner-Branth P,Shrestha PS,Strand TA

    更新日期：2017-01-17 00:00:00

  • Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation.

    abstract：:Patients with metabolic syndrome are at an increased risk of developing type 2 diabetes and cardiovascular diseases. The principal risk factor for development of metabolic syndrome is obesity, defined as a state of pathological hyperplasia or/and hypertrophy of adipose tissue. The number of mature adipocytes is determ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11102307

    authors： Wu LY,Chen CW,Chen LK,Chou HY,Chang CL,Juan CC

    更新日期：2019-09-28 00:00:00

  • Maternal Iodine Status and Associations with Birth Outcomes in Three Major Cities in the United Kingdom.

    abstract：:Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 54...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11020441

    authors： Snart CJP,Keeble C,Taylor E,Cade JE,Stewart PM,Zimmermann M,Reid S,Threapleton DE,Poston L,Myers JE,Simpson NAB,Greenwood DC,Hardie LJ

    更新日期：2019-02-20 00:00:00

  • Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults.

    abstract：:Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10111607

    authors： León-Mimila P,Villamil-Ramírez H,López-Contreras BE,Morán-Ramos S,Macias-Kauffer LR,Acuña-Alonzo V,Del Río-Navarro BE,Salmerón J,Velazquez-Cruz R,Villarreal-Molina T,Aguilar-Salinas CA,Canizales-Quinteros S

    更新日期：2018-11-01 00:00:00

  • Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores.

    abstract：:For mammals, vitamin A (retinol and metabolites) is an essential micronutrient that is required for the maintenance of life. Mammals cannot synthesize vitamin A but have to obtain it from their diet. Resorbed dietary vitamin A is stored in large quantities in the form of retinyl esters (REs) in cytosolic lipid droplet...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu9010013

    authors： Grumet L,Taschler U,Lass A

    更新日期：2016-12-27 00:00:00

  • Protocol for the Process Evaluation of a Complex, Statewide Intervention to Reduce Salt Intake in Victoria, Australia.

    abstract：:Systematic reviews of trials consistently demonstrate that reducing salt intake lowers blood pressure. However, there is limited evidence on how interventions function in the real world to achieve sustained population-wide salt reduction. Process evaluations are crucial for understanding how and why an intervention re...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10080998

    authors： Trieu K,Jan S,Woodward M,Grimes C,Bolam B,Nowson C,Reimers J,Davidson C,Webster J

    更新日期：2018-07-30 00:00:00

  • Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Paediatric Diseases.

    abstract：:The human intestinal microbiota, establishing a symbiotic relationship with the host, plays a significant role for human health. It is also well known that a disease status is frequently characterized by a dysbiotic condition of the gut microbiota. A probiotic treatment can represent an alternative therapy for enteric...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu10111723

    authors： Bozzi Cionci N,Baffoni L,Gaggìa F,Di Gioia D

    更新日期：2018-11-10 00:00:00

  • Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants.

    abstract：:Unlike milk-based infant formulas, soy-based infant formulas containing supplemental fructooligosaccharides (FOS) have not been clinically evaluated. A randomized, double-blind, 28 day parallel feeding trial compared gastrointestinal (GI) tolerance and hydration in healthy term newborn infants fed either a commerciali...

    journal_title：Nutrients

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.3390/nu7043022

    authors： Lasekan J,Baggs G,Acosta S,Mackey A

    更新日期：2015-04-22 00:00:00

  • Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.

    abstract：:The 5'-3' structure-specific endonuclease ERCC1/XPF (Excision Repair Cross-Complementation Group 1/Xeroderma Pigmentosum group F) plays critical roles in the repair of cisplatin-induced DNA damage. As such, it has been identified as a potential pharmacological target for enhancing clinical response to platinum-based c...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10111644

    authors： Heyza JR,Arora S,Zhang H,Conner KL,Lei W,Floyd AM,Deshmukh RR,Sarver J,Trabbic CJ,Erhardt P,Chan TH,Dou QP,Patrick SM

    更新日期：2018-11-03 00:00:00

  • Optimal Time and Target for Evaluating Energy Delivery after Adjuvant Feeding with Small Bowel Enteral Nutrition in Critically Ill Patients at High Nutrition Risk.

    abstract：:Small bowel enteral nutrition (SBEN) may improve nutrient delivery to critically ill patients intolerant of gastric enteral nutrition. However, the optimal time and target for evaluating SBEN efficacy are unknown. This retrospective cohort study investigates these parameters in 55 critically ill patients at high nutri...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11030645

    authors： Wang WN,Yang MF,Wang CY,Hsu CY,Lee BJ,Fu PK

    更新日期：2019-03-16 00:00:00

  • Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene.

    abstract：:In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless ...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11051093

    authors： Meléndez-Martínez AJ,Stinco CM,Mapelli-Brahm P

    更新日期：2019-05-16 00:00:00

  • In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface.

    abstract：:Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used t...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12113245

    authors： Hong SC,Ha JH,Lee JK,Jung SH,Kim JC

    更新日期：2020-10-23 00:00:00

  • Nutrient Timing: A Garage Door of Opportunity?

    abstract：:Nutrient timing involves manipulation of nutrient consumption at specific times in and around exercise bouts in an effort to improve performance, recovery, and adaptation. Its historical perspective centered on ingestion during exercise and grew to include pre- and post-training periods. As research continued, transla...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12071948

    authors： Arent SM,Cintineo HP,McFadden BA,Chandler AJ,Arent MA

    更新日期：2020-06-30 00:00:00

  • The Impact of Wealth Status on Food Intake Patterns in Filipino School-Aged Children and Adolescents.

    abstract：:Socio-economic status (SES) has an impact on food consumption in developing countries. However, the impact of SES on dietary patterns in Filipino school-aged children is currently unknown. The aim of this study was to fill this knowledge gap, using data from the 2013 National Nutrition Survey. Dietary intake of 11,691...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11122910

    authors： Angeles-Agdeppa I,Lenighan YM,Jacquier EF,Toledo MB,Capanzana MV

    更新日期：2019-12-02 00:00:00

  • Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress.

    abstract：:The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the present study, we discovered that leucine-h...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11092161

    authors： Ano Y,Kita M,Kitaoka S,Furuyashiki T

    更新日期：2019-09-09 00:00:00