当前位置： SCI文献检索 > Nutrients期刊下所有文献 > A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence.

A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence.

Abstract：

:Non-coeliac/non-allergic gluten/wheat sensitivity (NCG/WS) is a gluten-related disorder, the pathogenesis of which remains unclear. Recently, the involvement of an increased intestinal permeability has been recognized in the onset of this clinical condition. However, mechanisms through which it takes place are still unclear. In this review, we attempt to uncover these mechanisms by providing, for the first time, an integrated vision of recent scientific literature, resulting in a new hypothesis about the pathogenic mechanisms involved in NCG/WS. According to this, the root cause of NCG/WS is a particular dysbiotic profile characterized by decreased butyrate-producing-Firmicutes and/or Bifidobacteria, leading to low levels of intestinal butyrate. Beyond a critical threshold of the latter, a chain reaction of events and vicious circles occurs, involving other protagonists such as microbial lipopolysaccharide (LPS), intestinal alkaline phosphatase (IAP) and wheat α-amylase trypsin inhibitors (ATIs). NCG/WS is likely to be a multi-factor-onset disorder, probably transient and preventable, related to quality and balance of the diet, and not to the presence of gluten in itself. If future studies confirm our proposal, this would have important implications both for the definition of the disease, as well as for the prevention and therapeutic-nutritional management of individuals with NCG/WS.

journal_name

Nutrients

journal_title

Nutrients

authors

Leccioli V,Oliveri M,Romeo M,Berretta M,Rossi P

doi

10.3390/nu9111203

subject

Has Abstract

pub_date

2017-11-02 00:00:00

issue

11

issn

2072-6643

pii

nu9111203

journal_volume

9

pub_type

杂志文章,评审

相关文献

Nutrients文献大全
  • β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise.

    abstract：:Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflamma...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051438

    authors： Gálvez I,Martín-Cordero L,Hinchado MD,Ortega E

    更新日期：2020-05-16 00:00:00

  • Differential acute effects of selenomethionine and sodium selenite on the severity of colitis.

    abstract：:The European population is only suboptimally supplied with the essential trace element selenium. Such a selenium status is supposed to worsen colitis while colitis-suppressive effects were observed with adequate or supplemented amounts of both organic selenomethionine (SeMet) and inorganic sodium selenite. In order to...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu7042687

    authors： Hiller F,Oldorff L,Besselt K,Kipp AP

    更新日期：2015-04-10 00:00:00

  • Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2).

    abstract：:Obesity is characterized by an excessive body fat percentage (BF%). Animal and cell studies have shown benefits of vitamin A (VA) on BF% and lipid metabolism, but it is still controversial in humans. Furthermore, although some genetic variants may explain heterogeneity in VA plasma levels, their role in VA metabolic r...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12092588

    authors： Galmés S,Palou A,Serra F

    更新日期：2020-08-26 00:00:00

  • β-Cyclodextrin Does not Alter the Bioaccessibility and the Uptake by Caco-2 Cells of Olive By-Product Phenolic Compounds.

    abstract：:Alperujo-a two-phase olive mill waste that is composed of olive vegetation water and solid skin, pulp, and seed fragments - is a highly valuable olive by-product due to its high content in phenolic compounds. In this study, we assessed whether β-cyclodextrin (β-CD), which is used to extract and protect alpejuro phenol...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10111653

    authors： Malapert A,Tomao V,Margier M,Nowicki M,Gleize B,Dangles O,Reboul E

    更新日期：2018-11-03 00:00:00

  • DNA hypermethylation of the serotonin receptor type-2A gene is associated with a worse response to a weight loss intervention in subjects with metabolic syndrome.

    abstract：:Understanding the regulation of gene activities depending on DNA methylation has been the subject of much recent study. However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain. The aim of...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu6062387

    authors： Perez-Cornago A,Mansego ML,Zulet MA,Martinez JA

    更新日期：2014-06-23 00:00:00

  • Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene.

    abstract：:In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless ...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11051093

    authors： Meléndez-Martínez AJ,Stinco CM,Mapelli-Brahm P

    更新日期：2019-05-16 00:00:00

  • External Validation of Equations to Estimate Resting Energy Expenditure in 2037 Children and Adolescents with and 389 without Obesity: A Cross-Sectional Study.

    abstract：:We performed an external cross-validation study of 10 equations to estimate resting energy expenditure (REE) in 2037 children with and 389 without obesity. Inclusion criteria were Caucasian ethnicity, age ≤ 18 years, and availability of REE. REE was measured using indirect calorimetry. The correct classification fract...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051421

    authors： Bedogni G,Bertoli S,De Amicis R,Foppiani A,De Col A,Tringali G,Marazzi N,De Cosmi V,Agostoni C,Battezzati A,Sartorio A

    更新日期：2020-05-14 00:00:00

  • Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice.

    abstract：:The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051539

    authors： Yang J,Lee J,Kim Y

    更新日期：2020-05-25 00:00:00

  • Functional Relationship between Leptin and Nitric Oxide in Metabolism.

    abstract：:Leptin, the product of the ob gene, was originally described as a satiety factor, playing a crucial role in the control of body weight. Nevertheless, the wide distribution of leptin receptors in peripheral tissues supports that leptin exerts pleiotropic biological effects, consisting of the modulation of numerous proc...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11092129

    authors： Becerril S,Rodríguez A,Catalán V,Ramírez B,Unamuno X,Portincasa P,Gómez-Ambrosi J,Frühbeck G

    更新日期：2019-09-06 00:00:00

  • Thiamine Deficiency in Adolescents with Eating Disorders: A Prospective Cohort Study.

    abstract：BACKGROUND:Pediatric eating disorders (PED) patients are prone to nutritional deficiencies. Thiamine deficiency is well described in other malnutrition states but is not routinely screened for in PED. In the current study we evaluated the prevalence of thiamine deficiency among PED patients on their first admission to ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12051396

    authors： Bahat H,Reisler G,Brandriss N,Bar-Chaim A,Goldman M

    更新日期：2020-05-13 00:00:00

  • Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders.

    abstract：:Celiac disease (CD) is a chronic autoimmune enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. At the time of diagnosis, the frequency of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis in individuals with CD appears to be similar to that of the general p...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12040940

    authors： Valvano M,Longo S,Stefanelli G,Frieri G,Viscido A,Latella G

    更新日期：2020-03-28 00:00:00

  • First Trimester Serum Copper or Zinc Levels, and Risk of Pregnancy-Induced Hypertension.

    abstract：:Early identification of women at risk of developing pregnancy-induced hypertension (PIH) is very important. The involvement of copper (Cu) and zinc (Zn) in the oxidative balance suggests the possibility of their association with this disease, in which oxidative stress plays a key role. However, it has not been establi...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11102479

    authors： Lewandowska M,Sajdak S,Marciniak W,Lubiński J

    更新日期：2019-10-16 00:00:00

  • Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas.

    abstract：:The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of bot...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12030862

    authors： Trzeciak M,Olszewska B,Sakowicz-Burkiewicz M,Sokołowska-Wojdyło M,Jankau J,Nowicki RJ,Pawełczyk T

    更新日期：2020-03-24 00:00:00

  • Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes.

    abstract：:Geriatric patients with hip fractures often experience overlap in problems related to nutrition, including undernutrition, sarcopenia, and frailty. Such problems are powerful predictors of adverse responses, although few healthcare professionals are aware of them and therefore do not implement effective interventions....

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12123743

    authors： Inoue T,Maeda K,Nagano A,Shimizu A,Ueshima J,Murotani K,Sato K,Tsubaki A

    更新日期：2020-12-04 00:00:00

  • Effectiveness of A Multifactorial Intervention in Increasing Adherence to the Mediterranean Diet among Patients with Diabetes Mellitus Type 2: A Controlled and Randomized Study (EMID Study).

    abstract：:The Mediterranean diet (MD) is recognized as one of the healthiest dietary patterns and has benefits such as improving glycaemic control among patients with type 2 diabetes (T2DM). Our aim is to assess the effectiveness of a multifactorial intervention to improve adherence to the MD, diet quality and biomedical parame...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu11010162

    authors： Alonso-Domínguez R,García-Ortiz L,Patino-Alonso MC,Sánchez-Aguadero N,Gómez-Marcos MA,Recio-Rodríguez JI

    更新日期：2019-01-14 00:00:00

  • Dietary Patterns are Associated with Leukocyte LINE-1 Methylation in Women: A Cross-Sectional Study in Southern Italy.

    abstract：:Bioactive food compounds have different effects on global DNA methylation, an epigenetic mechanism associated with chromosomal stability and genome function. Since the diet is characterized by a mixture of foods, we aimed to identify dietary patterns in women, and to evaluate their association with long interspersed n...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11081843

    authors： Barchitta M,Maugeri A,Magnano San Lio R,Favara G,La Rosa MC,La Mastra C,Quattrocchi A,Agodi A

    更新日期：2019-08-09 00:00:00

  • Threshold-Effect Association of Dietary Cholesterol Intake with Dyslipidemia in Chinese Adults: Results from the China Health and Nutrition Survey in 2015.

    abstract：:The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 438...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11122885

    authors： Huang Q,Jiang H,Zhang B,Wang H,Jia X,Huang F,Wang L,Wang Z

    更新日期：2019-11-27 00:00:00

  • Caregivers' Role in the Effectiveness of Two Dutch School-Based Nutrition Education Programmes for Children Aged 7-12 Years Old.

    abstract：:Childhood eating behaviours can track into adulthood. Therefore, programmes that support early healthy eating, including school-based nutrition education programmes, are important. Although school-based programmes may be beneficial in improving nutrition knowledge, impact on actual fruit and vegetable (FV) intake is g...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu13010140

    authors： Verdonschot A,de Vet E,van Seeters N,Warmer J,Collins CE,Bucher T,Haveman-Nies A

    更新日期：2021-01-01 00:00:00

  • Food Composition Impacts the Accuracy of Wearable Devices When Estimating Energy Intake from Energy-Dense Food.

    abstract：:The present study aimed to assess the feasibility and reliability of an a3utomatic food intake measurement device in estimating energy intake from energy-dense foods. Eighteen volunteers aged 20-36 years were recruited from the University of Padova. The device used in the present study was the Bite Counter (Bite Techn...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11051170

    authors： Lorenzoni G,Bottigliengo D,Azzolina D,Gregori D

    更新日期：2019-05-24 00:00:00

  • Purification and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides and the Antihypertensive Effect of Chlorella sorokiniana Protein Hydrolysates.

    abstract：:Hot water was used to obtain Chlorella sorokiniana hot water extract (HWE). Subsequently, this byproduct was freeze-dried, hydrolysed at 50 °C using Protease N to obtain C. sorokiniana protein hydrolysates (PN-1), and then digested with a gastrointestinal enzyme (PN-1G). The inhibitory effects of the HWE and hydrolysa...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10101397

    authors： Lin YH,Chen GW,Yeh CH,Song H,Tsai JS

    更新日期：2018-10-01 00:00:00

  • Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption.

    abstract：:Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength and it is diagnosed by measurements of muscle mass, muscle strength, and physical performance. Sarcopenia affects quality of life and is associated with several adverse health effects. Muscle decl...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12020307

    authors： Rondanelli M,Rigon C,Perna S,Gasparri C,Iannello G,Akber R,Alalwan TA,Freije AM

    更新日期：2020-01-24 00:00:00

  • The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude.

    abstract：:Hypoxia induced by low O2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced me...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12123627

    authors： Dos Santos Quaresma M,Souza W,Lemos VA,Caris AV,Thomatieli-Santos RV

    更新日期：2020-11-25 00:00:00

  • Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study.

    abstract：:Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is as...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12113528

    authors： Del Río-Moreno M,Luque RM,Rangel-Zúñiga OA,Alors-Pérez E,Alcalá-Diaz JF,Roncero-Ramos I,Camargo A,Gahete MD,López-Miranda J,Castaño JP

    更新日期：2020-11-17 00:00:00

  • The Effect of an 8 Week Prescribed Exercise and Low-Carbohydrate Diet on Cardiorespiratory Fitness, Body Composition and Cardiometabolic Risk Factors in Obese Individuals: A Randomised Controlled Trial.

    abstract：BACKGROUND:Low-carbohydrate (LC) diets are an effective method for treating obesity and reducing cardiometabolic risk. However, exposure to LC diets is associated with reductions in muscle mass and increased osteoporosis risk in obese individuals. The combination of exercise with a LC diet appears to attenuate muscle m...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu12020482

    authors： Perissiou M,Borkoles E,Kobayashi K,Polman R

    更新日期：2020-02-14 00:00:00

  • Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models.

    abstract：:Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on ex...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11123067

    authors： Recena Aydos L,Aparecida do Amaral L,Serafim de Souza R,Jacobowski AC,Freitas Dos Santos E,Rodrigues Macedo ML

    更新日期：2019-12-16 00:00:00

  • The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells.

    abstract：:Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the associ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11050966

    authors： Araujo P,Belghit I,Aarsæther N,Espe M,Lucena E,Holen E

    更新日期：2019-04-27 00:00:00

  • Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn's Disease.

    abstract：:G protein-coupled receptor 43/free fatty acid receptor 2 (GPR43/FFAR2) is essential for polymorphonuclear (PMN) recruitment. We investigated the expression of GPR43/FFAR2 in the colon from Crohn's disease patients and whether dietary fiber in enteral nutrition increases GPR43+ polymorphonuclear infiltration in mucosa....

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu7075223

    authors： Zhao M,Zhu W,Gong J,Zuo L,Zhao J,Sun J,Li N,Li J

    更新日期：2015-07-01 00:00:00

  • Nutrition and respiratory health--feature review.

    abstract：:Diet and nutrition may be important modifiable risk factors for the development, progression and management of obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). This review examines the relationship between dietary patterns, nutrient intake and weight status in obstructive lung...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu7031618

    authors： Berthon BS,Wood LG

    更新日期：2015-03-05 00:00:00

  • Probiotics Dietary Supplementation for Modulating Endocrine and Fertility Microbiota Dysbiosis.

    abstract：:Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus Lactobacillus. This work presents the compiled and analysed results from the most up-to-date information from clinical trial...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12030757

    authors： López-Moreno A,Aguilera M

    更新日期：2020-03-13 00:00:00

  • Survival and Nutritional Status of Male and Female Heart Transplant Patients Based on the Nutritional Risk Index.

    abstract：:Malnutrition among heart-transplant patients may affect survival. The aim was to investigate the survival and nutrition status among male and female heart transplant patients who underwent transplantation, before and 1 year after surgery based on the nutritional risk index (NRI). The medical records of ninety heart-tr...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12123868

    authors： Almutawa DA,Almuammar M,Elshafie MM,Aljuraiban GS,Alnafisah A,Abulmeaty MMA

    更新日期：2020-12-17 00:00:00