Abstract：
:Leptin, the product of the ob gene, was originally described as a satiety factor, playing a crucial role in the control of body weight. Nevertheless, the wide distribution of leptin receptors in peripheral tissues supports that leptin exerts pleiotropic biological effects, consisting of the modulation of numerous processes including thermogenesis, reproduction, angiogenesis, hematopoiesis, osteogenesis, neuroendocrine, and immune functions as well as arterial pressure control. Nitric oxide (NO) is a free radical synthesized from L-arginine by the action of the NO synthase (NOS) enzyme. Three NOS isoforms have been identified: the neuronal NOS (nNOS) and endothelial NOS (eNOS) constitutive isoforms, and the inducible NOS (iNOS). NO mediates multiple biological effects in a variety of physiological systems such as energy balance, blood pressure, reproduction, immune response, or reproduction. Leptin and NO on their own participate in multiple common physiological processes, with a functional relationship between both factors having been identified. The present review describes the functional relationship between leptin and NO in different physiological processes.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Becerril S,Rodríguez A,Catalán V,Ramírez B,Unamuno X,Portincasa P,Gómez-Ambrosi J,Frühbeck Gdoi
10.3390/nu11092129subject
Has Abstractpub_date
2019-09-06 00:00:00issue
9issn
2072-6643pii
nu11092129journal_volume
11pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract：:Based on a nationally representative sample of young Mexican women aged 20 to 49 years (n = 3260), we sought to explore whether cardiovascular risk factors and acute myocardial infarction (AMI) were associated with vitamin D deficiency (VDD, defined as 25-OH-D <50 nmol/L). To this end, we obtained sociodemographic, se...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061211
更新日期：2019-05-28 00:00:00
abstract：:Metabolic syndrome (MetS) is a growing problem worldwide in adolescents. This study compared two sample populations of young people in Spain and China, and analyzed the association of birth weight and breastfeeding duration with MetS. A cross-sectional study was conducted in adolescents (10-15 years old); 1150 Chinese...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071568
更新日期：2019-07-11 00:00:00
abstract：:This study aimed to investigate the impact of food insecurity and poor nutrient intake on the psychological health of middle-aged and older adults during the COVID-19 pandemic. A sub-sample of 535 individuals aged 52 years and above, from the earlier cohort and interventional studies (n = 4) from four selected states ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13020353
更新日期：2021-01-25 00:00:00
abstract：:Obesity is associated to chronic low-grade metabolic inflammation and hypovitaminosis D. Among extra-skeletal effects, an important role in inflammation has been described for vitamin D (25(OH)D). Phase angle (PhA) is a bioelectrical impedance analysis (BIA) parameter that represents an indicator of cellular health in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081747
更新日期：2019-07-29 00:00:00
abstract：:Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic de...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6114984
更新日期：2014-11-10 00:00:00
abstract：:Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7125497
更新日期：2015-11-27 00:00:00
abstract：:Nephrolithiasis is a common medical condition influenced by multiple environmental factors, including diet. Since nutritional habits play a relevant role in the genesis and recurrence of kidney stones disease, dietary manipulation has become a fundamental tool for the medical management of nephrolithiasis. Dietary adv...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030779
更新日期：2020-03-15 00:00:00
abstract：:Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. T...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10020248
更新日期：2018-02-22 00:00:00
abstract：:Glaucoma is a multifactorial blinding disease with a major inflammatory component ultimately leading to apoptotic retinal ganglion cell (RGC) death. Pharmacological treatments lowering intraocular pressure can help slow or prevent vision loss although the damage caused by glaucoma cannot be reversed. Recently, nutriti...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11122931
更新日期：2019-12-03 00:00:00
abstract：:The role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), induces cell death by apoptosis in mature ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12051392
更新日期：2020-05-13 00:00:00
abstract：:Obesity, a recognized risk factor for breast cancer in postmenopausal women, is associated with higher mortality rates regardless of menopausal status, which could in part be explained by therapeutic escape. Indeed, adipose microenvironment has been described to influence the efficiency of chemo- and hormonal therapie...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11122839
更新日期：2019-11-20 00:00:00
abstract：:Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the grou...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092112
更新日期：2019-09-05 00:00:00
abstract：:Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflamma...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051438
更新日期：2020-05-16 00:00:00
abstract：:The incidence of prostate cancer has increased in Vietnam, but there have been few studies of the risk factors associated with this change. This retrospective case-control study investigated the relation of the intake of carotenoids and their food sources to prostate cancer risk. A sample of 652 participants (244 inci...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010070
更新日期：2018-01-11 00:00:00
abstract：:Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091967
更新日期：2019-08-21 00:00:00
abstract：:Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030595
更新日期：2019-03-12 00:00:00
abstract：:Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life, morbidity and mortality. Despite the new available criteria, its early diagnosis remains difficult, highlighting the necessity of looking for a valid muscle wasting biomarker. Myostatin, a muscle mass negative regulator, i...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12082401
更新日期：2020-08-11 00:00:00
abstract：:Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strate...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11040894
更新日期：2019-04-20 00:00:00
abstract：:Various aspects of protein intake are thought to be crucial for the prevention of sarcopenia in older adults. Information about the day-to-day variation in these aspects is lacking. Our objective was to examine whether daily protein intake, protein distribution across meals, number of meals providing adequate protein,...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091217
更新日期：2018-09-03 00:00:00
abstract：:Sociodemographic differences in dietary consumption were observed in different populations. The current study aimed to identify sociodemographic and lifestyle determinants of diet quality and to investigate the differences in diet quality between the three main language regions of Switzerland. Using data of the Swiss ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010126
更新日期：2019-01-09 00:00:00
abstract：:The adenylate cyclase 3 (ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10060789
更新日期：2018-06-19 00:00:00
abstract：:Hyperhomocysteinemia (HHcy) is a risk factor for atherosclerosis through mechanisms which are still incompletely defined. One possible mechanism involves the hypomethylation of the nuclear histone proteins to favor the progression of atherosclerosis. In previous cell studies, hypomethylating stress decreased a specifi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082182
更新日期：2020-07-23 00:00:00
abstract：:The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, high fat, and high fat...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6104610
更新日期：2014-10-22 00:00:00
abstract：:Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040715
更新日期：2019-03-27 00:00:00
abstract：:There is concern regarding the amount of fruit and vegetables consumed and high sugar intakes in children's diets. Regional dietary differences in the British Isles could underlie variations in health outcomes, but little is known about these differences. Our aim was to compare diets of children enrolled in observatio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9070724
更新日期：2017-07-08 00:00:00
abstract：:Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010017
更新日期：2018-12-20 00:00:00
abstract：:Life-course diet patterns may impact risk of disease, but little is known about dietary trends with aging. In a retrospective longitudinal analysis we estimated lifetime intake of animal products and adherence to vegetarian dietary patterns among 51,082 Adventist Health Study-2 (AHS-2) subjects using data from a relia...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9101118
更新日期：2017-10-13 00:00:00
abstract：:Skin is a major safeguard tissue in humans. Because biological barrier function is deteriorated by several kinds of stresses including exposure to ultra-violet (UV) rays, the protection and treatment of skin conditions by dietary supplements are important. We therefore evaluated the effects of dietary supplementation ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10070817
更新日期：2018-06-25 00:00:00
abstract：:The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as well as environmental factors, particularly diet, t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092216
更新日期：2019-09-13 00:00:00
abstract：:During the nutritional vulnerable period of 1-3 years of age, nutrient intake is often inadequate due to an unbalanced diet. Young child formula (YCF) has been proposed as a means of improving nutrition in this age group. We compared the food consumption and nutrient intake of 241 YCF consumers (YCF-C) to those of 206...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092213
更新日期：2019-09-13 00:00:00
