Abstract:
:The role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), induces cell death by apoptosis in mature adipocytes. This effect of the hormone is mediated by the cellular Ca2+ signaling pathway: a sustained increase of intracellular (cytosolic) Ca2+ concentration followed by activation of Ca2+-dependent initiators and effectors of apoptosis. In recent animal studies, we demonstrated that low vitamin D status is observed in diet-induced obesity (DIO). High intake of vitamin D3 in DIO decreased the weight of white adipose tissue and improved biomarkers related to adiposity and Ca2+ regulation. The anti-obesity effect of vitamin D (1,25(OH)2D3) in DIO was determined by the induction of Ca2+-mediated apoptosis in mature adipocytes executed by Ca2+-dependent apoptotic proteases (calpains and caspases). Thus, a high intake of vitamin D in obesity increases vitamin D nutritional status and normalizes vitamin D hormonal status that is accompanied by the reduction of adiposity. Overall, our findings imply that vitamin D may contribute to the prevention of obesity and obesity-related diseases and that the mechanism of the anti-obesity effect of 1,25(OH)2D3 includes induction of Ca2+-mediated apoptosis in adipocytes.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Sergeev INdoi
10.3390/nu12051392subject
Has Abstractpub_date
2020-05-13 00:00:00issue
5issn
2072-6643pii
nu12051392journal_volume
12pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract::Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fal...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12102929
更新日期:2020-09-24 00:00:00
abstract::(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of intestinal permeability in patients with ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030699
更新日期:2020-03-05 00:00:00
abstract::Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030518
更新日期:2019-02-28 00:00:00
abstract::The dietary fiber gap that is present in many countries co-exists with a low intake of grain legumes (pulses) that have 2-3 times more dietary fiber than cereal grains that are commonly recommended to increase fiber intake. Given the relationships among dietary fiber, gut health and chronic disease risk, a study was u...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030593
更新日期:2020-02-25 00:00:00
abstract::The objective of this study was to inform consumer-facing dietary guidance by (1) adapting the current University of North Carolina at Chapel Hill (UNC) food processing framework to include a home processing (HP) component and (2) pilot testing the adapted version using a nationally representative sample of foods cons...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082373
更新日期:2020-08-08 00:00:00
abstract::Reduction in cholesterol blood levels represents one of the therapeutic goals to achieve in order to reduce the occurrence of cardiovascular diseases. Commonly, this goal is attempted by promoting healthy lifestyle behaviors and low-fat diets. Recently, several nutraceuticals have been shown to possess cholesterol-low...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010163
更新日期:2019-01-14 00:00:00
abstract::Our group built a genetic risk score (GRS) of the plasma triglyceride (TG) response to an omega-3 (n-3) fatty acid (FA) supplementation in Caucasian Canadians that explained 21.53% of the TG variance. The objective was to refine the GRS by fine mapping and to test its association with the TG response in young Mexican ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040737
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:Celiac disease (CD) is an immunologically-mediated disorder characterized by duodenal mucosa villi atrophy. Iron absorption is usually reduced in celiac patients making every kind of oral iron treatment unhelpful because of malasorption. Feralgine™ is a new product that has been demonstrated to be more bioav...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040887
更新日期:2019-04-20 00:00:00
abstract::The authors wish to make a correction to the published version of their paper [...]. ...
journal_title:Nutrients
pub_type: 已发布勘误
doi:10.3390/nu11081807
更新日期:2019-08-05 00:00:00
abstract::This is the first study to evaluate vitamin K status in relation to dietary intake and phenylalanine dietary compliance in patients with phenylketonuria (PKU). The dietary and PKU formula intake of vitamin K was calculated in 34 PKU patients, with vitamin K status determined by the measurement of prothrombin induced b...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061772
更新日期:2020-06-14 00:00:00
abstract::Iron deficiency is the most common micronutrient deficiency in the world. Women of reproductive age and young children are particularly vulnerable. Iron deficiency in late prenatal and early postnatal periods can lead to long-term neurobehavioral deficits, despite iron treatment. This may occur because screening and t...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10020227
更新日期:2018-02-17 00:00:00
abstract::Our purpose was to study the relationship of adherence to the Mediterranean diet (MedDiet) with urinary factors that favor the formation of renal calcium and uric acid stones in overweight and obese participants who had metabolic syndrome. This cross-sectional study examined 267 participants. A well-known MedDiet scor...
journal_title:Nutrients
pub_type: 杂志文章,多中心研究
doi:10.3390/nu11081708
更新日期:2019-07-24 00:00:00
abstract::Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7125497
更新日期:2015-11-27 00:00:00
abstract::Long term nut consumption is associated with reduced risk of coronary heart disease and better cognitive function. This study examined supplementing habitual diets with almonds or carbohydrate-rich snack foods (providing 15% energy) on biomarkers of cardiovascular and metabolic health, mood and cognitive performance. ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041180
更新日期:2020-04-23 00:00:00
abstract::Little is known about iodine nutritional status in island countries in the Pacific Ocean. The primary objective of this study was to report for the first time the iodine nutritional status of people in Nauru. In addition, sources of iodine nutrition (i.e., water and salt) were investigated. A school-based cross-sectio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8090520
更新日期:2016-08-23 00:00:00
abstract::Senses of smell and taste, saliva flow, and dental status are considered as important factors for the maintenance of a good nutritional status. Salivary secretory rates, chemosensory function, burning mouth sensation, halitosis and dental status were investigated in 58 primary Sjögren's syndrome (pSS) patients, 22 non...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020264
更新日期:2019-01-24 00:00:00
abstract::Celiac disease (CD) is a chronic autoimmune enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. At the time of diagnosis, the frequency of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis in individuals with CD appears to be similar to that of the general p...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040940
更新日期:2020-03-28 00:00:00
abstract::Proper nutrition plays a major role in preventing diseases and, therefore, nutritional interventions constitute crucial strategies in the field of Public Health. Nutrigenomics and nutriproteomics are arising from the integration of nutritional, genomics and proteomics specialties in the era of postgenomics medicine. I...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12020512
更新日期:2020-02-18 00:00:00
abstract::Consumption of low-glycemic index (GI) carbohydrates (CHO) may be superior to high-GI CHO before exercise by increasing fat oxidation and decreasing carbohydrate oxidation. We compared the effects of pre-exercise feeding of a low-GI lentil-based sports nutrition bar with a high-GI bar on metabolism and performance dur...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu12040982
更新日期:2020-04-02 00:00:00
abstract::High physical activity (PA) in patients with anorexia nervosa (AN) is hypothesized to be, at least in part, a consequence of hypoleptinemia. However, most studies on the association of leptin and PA in AN were performed in adolescents or young adults, and PA was generally measured with subjective tools. We aimed to ex...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9111210
更新日期:2017-11-03 00:00:00
abstract::Heating oils and fats for a considerable length of time results in chemical reactions, leading to the aggravation of a free radical processes, which ultimately contributes to atherosclerosis. Our study focused on elucidating the effect of feeding heated oils with or without dietary cholesterol on the development of at...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101527
更新日期:2018-10-17 00:00:00
abstract::This study investigated the gastroprotective efficacy of synthesized scoparone derivatives on experimentally induced gastritis and their toxicological safety. Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats. Am...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7031945
更新日期:2015-03-13 00:00:00
abstract::The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061795
更新日期:2020-06-17 00:00:00
abstract::The present study investigated the effects of breast tumors on the blood and tissue distribution of essential trace mineral selenium (Se), and oxidative stress status of mice. Female 10-week-old BALB/cByJNarl mice were randomly assigned into control (CNL) and breast tumor-bearing (TB) groups. TB mice were injected sub...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5020594
更新日期:2013-02-20 00:00:00
abstract::In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9091017
更新日期:2017-09-14 00:00:00
abstract::Accumulating evidence clarifies that intestinal barrier function, for example, by the mucus layer, antimicrobial peptides, immune systems, and epithelial tight junctions, plays crucial roles in maintaining our health. We reported previously that yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 an...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122998
更新日期:2019-12-07 00:00:00
abstract::The protein fractions of cocoa have been implicated influencing both the bioactive potential and sensory properties of cocoa and cocoa products. The objective of the present review is to show the impact of different stages of cultivation and processing with regard to the changes induced in the protein fractions. Speci...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11020428
更新日期:2019-02-19 00:00:00
abstract::Soyfoods have long been prized among vegetarians for both their high protein content and versatility. Soybeans differ markedly in macronutrient content from other legumes, being much higher in fat and protein, and lower in carbohydrate. In recent years however, soyfoods and specific soybean constituents, especially is...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu2080855
更新日期:2010-08-01 00:00:00
abstract::Obesity is associated with food and eating addiction (FA), but the biobehavioral markers of this condition are poorly understood. To characterize FA, we recruited 18 healthy controls and overweight/obese adults with (n = 31) and without (n = 17) FA (H-C, FAOB, NFAOB, respectively) to assess alpha brain asymmetry at re...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113563
更新日期:2020-11-20 00:00:00
abstract::Our aim is evaluating the changes in weight and dietary habits in a sample of outpatients with obesity after 1 month of enforced lockdown during the COVID-19 pandemic in Northern Italy. In this observational retrospective study, the patients of our Obesity Unit were invited to answer to a 12-question multiple-choice q...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072016
更新日期:2020-07-07 00:00:00