Abstract:
:This study investigated the gastroprotective efficacy of synthesized scoparone derivatives on experimentally induced gastritis and their toxicological safety. Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats. Among these compounds, 5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin were found to have gastroprotective activity greater than the standard drug rebamipide; 6-methoxy-7,8-methylenedioxycoumarin, 6-methoxy-7,8-(1-methoxy)-methylenedioxycoumarin, 6,7-methylenedioxycoumarin, and 6,7-(1-methoxy)-methylenedioxycoumarin were found to be equipotent or less potent that of rebamipide. Pharmacological studies suggest that the presence of a methoxy group at position C-5 or C-8 of the scoparone's phenyl ring significantly improves gastroprotective activity, whereas the presence of a dioxolane ring at C-6, C-7, or C-8 was found to have decreased activity. In order to assess toxicological safety, two of the potent gastroprotective scoparone derivatives-5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin-were examined for their acute toxicity in mice as well as their effect on cytochrome P450 (CYP) enzyme activity. These two compounds showed low acute oral toxicity in adult male and female mice, and caused minimal changes to CYP3A4 and CYP2C9 enzyme activity. These results indicate that compared to other scoparone derivatives, 5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin can improve gastroprotective effects, and they have low toxicity and minimal effects on drug-metabolizing enzymes.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Son DJ,Lee GR,Oh S,Lee SE,Choi WSdoi
10.3390/nu7031945subject
Has Abstractpub_date
2015-03-13 00:00:00pages
1945-64issue
3issn
2072-6643pii
nu7031945journal_volume
7pub_type
杂志文章相关文献
Nutrients文献大全abstract::In a study using a randomized crossover approach, cyclists (n = 20, overnight fasted) engaged in three 75 km time trials while ingesting water (WAT) or carbohydrate (0.2 g/kg every 15 min) from bananas (BAN) or a 6% sugar beverage (SUG). Blood samples were collected pre-exercise and 0 h, 1.5 h, and 21 h post-exercise ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10111658
更新日期:2018-11-04 00:00:00
abstract::Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whos...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061706
更新日期:2020-06-07 00:00:00
abstract::Natural polysaccharides, particularly galactomannans, are potential candidates for treatment of alcoholic liver diseases (ALD). However, applications are restricted due to the physicochemical properties associated with the high molecular weight. In this work, guar gum galactomannans were partially hydrolyzed by β-mann...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11050963
更新日期:2019-04-27 00:00:00
abstract::Despite several reports on the relationship between metabolic and neurodegenerative diseases, the effect of a high-sugar diet (HSD) on brain function is still unknown. Given the crucial role of oxidative stress in the pathogenesis of these disorders, this study was the first to compare the effect of an HSD on the acti...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12103181
更新日期:2020-10-18 00:00:00
abstract::The joint symposium of The Omega-3 Centre and the Australasian Section American Oil Chemists Society; Recent Advances in Omega-3: Health Benefits, Sources, Products and Bioavailability, was held November 7, 2013 in Newcastle, NSW, Australia. Over 115 attendees received new information on a range of health benefits, aq...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6093727
更新日期:2014-09-16 00:00:00
abstract::Hypertension is affected by both genetic and dietary factors. This study aimed to examine the interaction between dietary sodium/potassium intake, sodium-potassium ratios, and FGF5 rs16998073 and link these with increased risk for developing hypertension. Using data from the Health Examinee (HEXA) Study of the Korean ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072121
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:Limited data were available on trends of US dietary nutrients especially for specific subgroups; Methods: Dietary intakes of energy and 36 kinds of nutrients were analyzed in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2016 and by age and sex, socioeconomic status, race/ethnici...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112617
更新日期:2019-11-01 00:00:00
abstract::Carotenoids are diet-dependent milk components that are important for the visual and cognitive development of an infant. This study determined β-carotene, lycopene and lutein + zeaxanthin in breastmilk and its associations with dietary intake from healthy Polish mothers in the first six months of lactation. Concentrat...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010193
更新日期:2019-01-18 00:00:00
abstract::The association of high vitamin A intake and low bone mineral density (BMD) is still controversial. To determine the association of dietary vitamin A intake and serum 25-hydroxyvitamin D (25(OH)D) concentration with BMD, a total of 6481 subjects (2907 men and 3574 women) aged ≥50 years from the Korean National Health ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7031716
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:Nutritional interventions may have positive effects on sarcopenia and body composition. OBJECTIVE:to evaluate the effectiveness of extra virgin olive oil (EVOO) consumption and a healthy traditional Brazilian diet (DieTBra) on improving sarcopenia indicators and reducing total body fat in severe obesity. M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051498
更新日期:2020-05-21 00:00:00
abstract::Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11010025
更新日期:2018-12-22 00:00:00
abstract::An activity-guided search for compounds influencing glucose metabolism in extracts from aronia (Aronia melanocarpa, A.), pomegranate (Punica granatum L., P.), and red grape (Vitis vinifera, RG) was carried out. The three extracts were fractionated by means of membrane chromatography to separate the anthocyanins from o...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051166
更新日期:2019-05-24 00:00:00
abstract::The relationship between fiber intake and telomere length was evaluated using a cross-sectional design and an NHANES sample of 5674 U.S. adults. Another purpose was to test the impact of potential confounders on the association. Fiber consumption was measured using a 24 h recall and telomere length was indexed using t...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10040400
更新日期:2018-03-23 00:00:00
abstract::Peptides from fish may beneficially affect several metabolic outcomes, including gut health and inflammation. The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, hence this study aimed to evaluate the effect of a cod protein hydrolysate (CPH) supplement on ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11071635
更新日期:2019-07-17 00:00:00
abstract::Health claims may contribute to better informed and healthier food choices and to improved industrial competitiveness by marketing foods that support healthier lifestyles in line with consumer preferences. With the more stringent European Union regulation of nutrition and health claims, insights into consumers' health...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5010082
更新日期:2013-01-10 00:00:00
abstract::Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on s...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030595
更新日期:2019-03-12 00:00:00
abstract::The study objectives were to examine total and individual lignan intakes and their dietary sources in postmenopausal Polish women and to investigate the relationship between lignan intake and the prevalence of cardiovascular disease (CVD), hypertension, hypercholesterolemia and central obesity. A total of 2599 postmen...
journal_title:Nutrients
pub_type: 杂志文章,多中心研究
doi:10.3390/nu10070865
更新日期:2018-07-04 00:00:00
abstract::We investigated changes in fatty acid desaturases, D5D, D6D, D9-16D and D9-18D, and their relationship with oxidative stress, matrix metalloproteinases (MMPs) and serum TNF-alpha in two rat models of non-alcoholic fatty liver disease NAFLD. Eight-week-old male Wistar rats fed for 3 weeks with methionine-choline⁻defici...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040799
更新日期:2019-04-08 00:00:00
abstract::Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic de...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6114984
更新日期:2014-11-10 00:00:00
abstract::Exposure to environmental factors in early life can influence developmental processes and long-term health in humans. Early life nutrition and maternal diet are well-known examples of conditions shown to influence the risk of developing metabolic diseases, including type 2 diabetes mellitus and cardiovascular diseases...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7115467
更新日期:2015-11-17 00:00:00
abstract::A number of previous investigations have been designed to determine the effect of acute caffeine intake on the rate of fat oxidation during exercise. However, these investigations have shown contradictory results due to the differences in the exercise protocols used or the co-ingestion of caffeine with other substance...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123603
更新日期:2020-11-24 00:00:00
abstract::Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus Lactobacillus. This work presents the compiled and analysed results from the most up-to-date information from clinical trial...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030757
更新日期:2020-03-13 00:00:00
abstract::Accumulating epidemiological evidence suggests that anthocyanin intake is associated with reduced risks of cardiometabolic disorders, highlighting the importance of incorporating the phytochemical in our diets. Numerous food-based intervention studies have examined, in controlled meal settings, the role of anthocyanin...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123781
更新日期:2020-12-09 00:00:00
abstract::Polyphenols are found ubiquitously in plants and their regular consumption has been associated with a reduced risk of a number of chronic diseases, including cancer, cardiovascular disease (CVD) and neurodegenerative disorders. Rather than exerting direct antioxidant effects, the mechanisms by which polyphenols expres...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu2111106
更新日期:2010-11-01 00:00:00
abstract::Home environment and family lifestyle practices have an influence on child obesity risk, thereby making it critical to systematically examine these factors. Thus, parents (n = 489) of preschool children completed a cross-sectional online survey which was the baseline data collection conducted, before randomization, in...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9060604
更新日期:2017-06-14 00:00:00
abstract::One of the deadliest cancers among women is a breast cancer. Research has shown that two natural substances occurring in propolis, caffeic acid (CA) and caffeic acid phenethyl ester (CAPE), have significant anticancer effects. The purpose of our in vitro study was to compare cytotoxic activity and migration rate inhib...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101144
更新日期:2017-10-19 00:00:00
abstract::Gluten-free diets are increasingly chosen in the Western world, even in the absence of a diagnosis of celiac disease. Around 10% of people worldwide self-report gluten-related complaints, including intestinal and extra-intestinal symptoms. In most cases, these subjects would be labeled as patients suffering from irrit...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123735
更新日期:2020-12-04 00:00:00
abstract::Helicobacter pylori (H. pylori) may be involved in diabetes and other insulin-related processes. This study aimed to investigate the associations between H. pylori infection and the risks of type 2 diabetes, impaired glucose tolerance (IGT), diabetic nephropathy, and poor glycemic control. We retrospectively evaluated...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081874
更新日期:2019-08-12 00:00:00
abstract::The objective of this cross-sectional study was to evaluate the relationship between micronutrient status and obesity, lipids, insulin resistance and chronic inflammation in children. Weight, height, waist circumference and body composition (dual-energy X-ray absorptiometry (DEXA)) were determined in 197 school-aged c...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5125012
更新日期:2013-12-10 00:00:00
abstract::This cross-sectional study is aimed at assessing sodium (Na) and potassium (K) content and the molar Na:K ratios of the most commonly available ready-to-eat street foods in Tajikistan and Kyrgyzstan. Four different samples of each of these foods were collected and 62 food categories were evaluated through bromatologic...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010098
更新日期:2018-01-16 00:00:00