Abstract：
:Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate⁻SUCNR1 signaling in gut immune functions.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Connors J,Dawe N,Van Limbergen Jdoi
10.3390/nu11010025subject
Has Abstractpub_date
2018-12-22 00:00:00issue
1issn
2072-6643pii
nu11010025journal_volume
11pub_type
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