Adipose Tissue Lipophilic Index and Risk of Ischemic Stroke-A Danish Case-Cohort Study.

Abstract:

:Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemic stroke and its subtypes. A case-cohort study was conducted based on the Danish cohort study Diet, Cancer, and Health, which includes 57,053 subjects aged 50⁻64 years at enrolment. A subcohort (n = 3500) was randomly drawn from the whole cohort. All ischemic stroke cases were validated and categorized into subtypes. The lipophilic index was calculated based on fatty acid profiles in adipose tissue. Subjects were divided into quintiles and a weighted Cox proportional hazards regression model was used to calculate hazard ratios. After appropriate exclusions, a subcohort of 3194 subjects and 1752 cases of ischemic stroke were included. When comparing the fifth quintile of the lipophilic index with the first quintile, the hazard ratio for ischemic stroke was 0.92 (95% confidence interval 0.75, 1.13) and the trend across quintiles was not statistically significant (p = 0.1727). In conclusion, no association was found between the lipophilic index and ischemic stroke or its subtypes.

journal_name

Nutrients

journal_title

Nutrients

authors

Tram L,Krogh Venø S,Dahm CC,H Thomsen B,Berg Johansen M,Overvad K,Berg Schmidt E

doi

10.3390/nu10111570

subject

Has Abstract

pub_date

2018-10-23 00:00:00

issue

11

issn

2072-6643

pii

nu10111570

journal_volume

10

pub_type

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