Abstract:
:Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in post-transcriptional gene silencing by inducing mRNA degradation or translational repression by binding to a target messenger RNA. They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials).
journal_name
Nutrientsjournal_title
Nutrientsauthors
Quintanilha BJ,Reis BZ,Duarte GBS,Cozzolino SMF,Rogero MMdoi
10.3390/nu9111168subject
Has Abstractpub_date
2017-10-27 00:00:00issue
11issn
2072-6643pii
nu9111168journal_volume
9pub_type
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