Abstract:
BACKGROUND AND AIM:Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena(®) ELFA(®)955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements. METHOD:A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement. RESULT:Chronic WGOE supplementation did not affect any measures of cognition. CONCLUSION:It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition. It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Wong RH,Howe PR,Bryan J,Coates AM,Buckley JD,Berry NMdoi
10.3390/nu4050331subject
Has Abstractpub_date
2012-05-01 00:00:00pages
331-42issue
5issn
2072-6643pii
nu4050331journal_volume
4pub_type
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