Abstract：
:Cow's milk proteins cause allergic symptoms in 2% to 3% of all infants. In these individuals, the physiological mechanism of tolerance is broken with subsequent possible sensitization to antigens, which can lead eventually to allergic responses. The present review aims to provide an overview of different aspects of immune modulation by dietary intervention in cow's milk allergy (CMA). It focuses on pathogenetic mechanisms of different CMA related disorders, e.g., gastroesophageal reflux and eosinophilic esophagitis, highlighting the role of dietary management on innate and adaptive immune systems. The traditional dietary management of CMA has greatly changed in the last years, moving from a passive approach, consisting of an elimination diet to relieve symptoms, to a "proactive" one, meaning the possibility to actively modulate the immune system. Thus, new insights into the role of hydrolysates and baked milk in immunomodulation are addressed here. Additionally, nutritional components, such as pre- and probiotics, may target the immune system via microbiota, offering a possible road map for new CMA prevention and treatment strategies.
journal_name
Nutrientsjournal_title
Nutrientsauthors
D'Auria E,Salvatore S,Pozzi E,Mantegazza C,Sartorio MUA,Pensabene L,Baldassarre ME,Agosti M,Vandenplas Y,Zuccotti Gdoi
10.3390/nu11061399subject
Has Abstractpub_date
2019-06-21 00:00:00issue
6issn
2072-6643pii
nu11061399journal_volume
11pub_type
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