Abstract:
:Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15´-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14´-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response element (RARE)-mediated signalling in DR5/RARE-reporter mice and potently increase retinoid-reporter target gene expression in ATA14CA-supplemented mice and treated MM6 cells. Further metabolism to all-trans-13,14-dihydroretinoic acid (ATDHRA) may be the key for its potent effects on retinoid target gene activation in ATA14CA-treated MM6 cells and in liver of supplemented mice. We conclude that besides RAs, there are alternative ways to activate RAR-response pathways in the mammalian organism. ATA14CA alone and in combination with its metabolite ATDHRA may be an alternative pathway for potent RAR-mediated signalling.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Aydemir G,Domínguez M,de Lera AR,Mihaly J,Törőcsik D,Rühl Rdoi
10.3390/nu11092084subject
Has Abstractpub_date
2019-09-04 00:00:00issue
9issn
2072-6643pii
nu11092084journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract::Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as w...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092661
更新日期:2020-08-31 00:00:00
abstract::Male C57BL/6J mice were used to determine the possible therapeutic effects of our previously described tart cherry extract in a chronic obesity mouse model on metabolic parameters, glucose tolerance, inflammatory mediators, and antioxidant capacity. The control group received standard mouse chow, and the high fat cont...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091966
更新日期:2019-08-21 00:00:00
abstract::High sodium intake is estimated to cause approximately 3 million deaths per year worldwide. The estimated average sodium intake of 3.95 g/day far exceeds the recommended intake. Population sodium reduction should be a global priority, while simultaneously ensuring universal salt iodization. This article identifies hig...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092543
更新日期:2020-08-22 00:00:00
abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5041186
更新日期:2013-04-09 00:00:00
abstract::Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061588
更新日期:2020-05-28 00:00:00
abstract::Normal-weight obesity (NWO) has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in early adulthood. The aim of this study was to investigate the associations between NWO and cardiometabolic risk factors in a large population of Colombian youn...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041106
更新日期:2020-04-16 00:00:00
abstract::Preserving the efficacy of probiotic bacteria exhibits paramount challenges that need to be addressed during the development of functional food products. Several factors have been claimed to be responsible for reducing the viability of probiotics including matrix acidity, level of oxygen in products, presence of other...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11071591
更新日期:2019-07-13 00:00:00
abstract::Sialic acid (SA) is an integral component of gangliosides and signaling molecules in the brain and its dietary intake may support cognitive development. We previously reported that feeding sialyllactose, a milk oligosaccharide that contains SA, alters SA content and diffusivity in the pig brain. The present research s...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10040395
更新日期:2018-03-23 00:00:00
abstract::This study aimed to observe the relationship between iodine nutrition status (dietary iodine intake and estimated iodine intake based on urinary iodine concentration (UIC)) and thyroid disease-related hormones. This study involved 6090 subjects >19 years old with valid UIC, assessed between 2013 and 2015 by the Korean...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112757
更新日期:2019-11-13 00:00:00
abstract::Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10010043
更新日期:2018-01-05 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease, sometimes ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Various hits including excessive hepatic steatosis, oxidative stress, apoptosis, and inflammation, contribute to NASH development. Gallic ac...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051479
更新日期:2020-05-20 00:00:00
abstract::The popularity of yogurt has increased among consumers due to its perceived health benefits. This study examined the cross-sectional association between yogurt consumption and nutrient intake/adequacy, dietary quality, and body weight in children and adults. National Health and Nutrition Examination Survey 2001-2016 d...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113435
更新日期:2020-11-09 00:00:00
abstract::Previous studies demonstrated that hyperglycemic glucose concentrations are observed in children that are overweight or have obesity. The aim of this study was to evaluate the effect of a 12 month lifestyle intervention on free-living glycemic profiles in children that were overweight or had obesity, and the associati...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051228
更新日期:2020-04-26 00:00:00
abstract::The relative impacts on food purchases of many alternative front-of-pack nutritional labelling systems were tested, with various methods-from opinion pool to nationwide experiments. Clearly, some systems induce better purchasing responses, having better nutritional impacts on food baskets. Nonetheless, we still ignore...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092870
更新日期:2020-09-19 00:00:00
abstract::Gravieras are 'gruyere' type hard cheeses with a variety of different products and the second highest consumption in Greece. In this study, we present a dietary intake assessment and a nutritional characterization of pre-packed graviera products sold in the Greek market using Nutri-Score Front of Pack Label (FoPL). Th...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13020295
更新日期:2021-01-20 00:00:00
abstract::Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasmino...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7125512
更新日期:2015-12-02 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic processes that lead to abnormally high levels of blood glucose. Preceding the development of T2DM is insulin resistance (IR), a disorder associated with suppressed or delayed responses to insulin. The effects of this response are pred...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11020408
更新日期:2019-02-15 00:00:00
abstract::Hypertension and arterial stiffening are independent predictors of cardiovascular mortality. Flavonoids may exert some vascular protection. We investigated the effects of black tea on blood pressure (BP) and wave reflections before and after fat load in hypertensives. According to a randomized, double-blind, controlle...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7021037
更新日期:2015-02-04 00:00:00
abstract::Epidemiological and experimental studies reveal that Western dietary patterns contribute to chronic kidney disease, whereas dietary restriction (DR) or dietary polyphenols such as green tea polyphenols (GTPs) can ameliorate the progression of kidney injury. This study aimed to investigate the renal protective effects ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9050497
更新日期:2017-05-14 00:00:00
abstract:BACKGROUND:The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease. METHODS:We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challeng...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112551
更新日期:2019-10-23 00:00:00
abstract::The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111785
更新日期:2018-11-16 00:00:00
abstract::Iron is an essential mineral nutrient for all living organisms, involved in a plurality of biological processes. Its deficit is the cause of the most common form of anemia in the world: iron deficiency anemia (IDA). This paper reviews iron content in various parts of 1228 plant species and its absorption from herbal p...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7125535
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:Several studies demonstrate that the provision of personalized lifestyle advice, based on genetics, can help motivate individuals to engage in greater nutrition and physical activity changes compared to the provision of population-based advice. The theoretical mechanism behind this phenomenon is poorly under...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123768
更新日期:2020-12-08 00:00:00
abstract::Lower vitamin D status at birth and during infancy has been associated with increased incidence of eczema and food allergies. The aim of this study was to investigate the effect of early infancy vitamin D supplementation on allergic disease outcomes in infants at "hereditary risk" of allergic disease, but who had suff...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061747
更新日期:2020-06-11 00:00:00
abstract::Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 54...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020441
更新日期:2019-02-20 00:00:00
abstract::The Mediterranean diet (MD) is linked to decreased risk of chronic disease, such as cardiovascular disease, obesity, hypertension, diabetes mellitus and cognitive disease. Given the health promoting aspects of this diet, we conducted a secondary analysis of data from the National Nutrition and Physical Activity Survey...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051251
更新日期:2020-04-28 00:00:00
abstract::Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourtee...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12020430
更新日期:2020-02-07 00:00:00
abstract::Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variab...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020298
更新日期:2019-01-30 00:00:00
abstract::How moderate white wine consumption modulates inflammatory cells infiltration of the ischemic myocardium following permanent coronary ligation was the key question addressed in this study. Male Sprague-Dawley rats were given either a combination of different white wines or water only for 28 days. Three peri-infarct/bo...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081890
更新日期:2019-08-14 00:00:00
abstract::Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030518
更新日期:2019-02-28 00:00:00