Abstract：
:Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (p = 0.047), Type 2 diabetes (p = 0.026), and metabolic risk (p = 0.021). The study shows that genetic variation can influence inflammation and omega-3 response, and that the LGI-Ob score could be a useful tool to classify subjects at inflammatory risk and more prone to suffer metabolic syndrome and associated metabolic disturbances.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Galmés S,Cifre M,Palou A,Oliver P,Serra Fdoi
10.3390/nu11020298subject
Has Abstractpub_date
2019-01-30 00:00:00issue
2issn
2072-6643pii
nu11020298journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Although a number of studies explain the association between dietary patterns, which take into account that foods are eaten in combination, and breast cancer risk, the findings are inconsistent. We examined the association between dietary patterns and multi-grain rice intake, and the risk of breast cancer in a large-s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082273
更新日期：2020-07-29 00:00:00
abstract：:The purpose of this study was to explore the effect of the frequency of participation in horticultural activity types on psychological well-being and fruit and vegetable intake. The study sought to understand the mediating effect of psychological well-being between the frequency of types of horticultural activities an...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113296
更新日期：2020-10-28 00:00:00
abstract：:High sugar-sweetened beverage (SSB) consumption has been linked with obesity. The present study examined the associations between adolescent SSB intake and body mass index (BMI), waist circumference (WC), and overweight status in early adulthood, and modelled the association of alternative beverage substitution with B...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11122928
更新日期：2019-12-03 00:00:00
abstract：:Hearing loss (HL) is a major public health problem. Nutritional factors can affect a variety of diseases, such as HL, in humans. Thus far, several studies have evaluated the association between nutrition and hearing. These studies found that the incidence of HL was increased with the lack of single micro-nutrients suc...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11020307
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Cardiovascular diseases are the main cause of deaths in the United Arab Emirates and reducing dietary salt intake is recommended to improve the population's health. METHODS:a cross-sectional survey was given to 401 students from the University of Sharjah to investigate knowledge, attitudes, and practices re...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11050941
更新日期：2019-04-26 00:00:00
abstract：:Nutrient timing involves manipulation of nutrient consumption at specific times in and around exercise bouts in an effort to improve performance, recovery, and adaptation. Its historical perspective centered on ingestion during exercise and grew to include pre- and post-training periods. As research continued, transla...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12071948
更新日期：2020-06-30 00:00:00
abstract：:Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 time...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11092126
更新日期：2019-09-06 00:00:00
abstract：:Noncommunicable diseases (NCDs) are considered to be the leading cause of death worldwide. Inadequate fruit and vegetable intake have been recognized as a risk factor for almost all NCDs (type 2 diabetes mellitus, cancer, and cardiovascular and neurodegenerative diseases). The main aim of this review is to examine the...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11102381
更新日期：2019-10-06 00:00:00
abstract：:This study aims to evaluate whether incorporating gender differences in portion sizes as part of quantifying a food frequency questionnaire influences the association of total energy intake with mortality. The analysis included 156,434 participants (70,142 men and 86,292 women) in the Multiethnic Cohort Study, aged 45...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102914
更新日期：2020-09-23 00:00:00
abstract：:Serum amyloid A (SAA) was recently associated with metabolic endotoxemia, obesity and insulin resistance. Concurrently, insufficient sleep adversely affects metabolic health and is an independent predisposing factor for obesity and insulin resistance. In this study we investigated whether sleep loss modulates SAA prod...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9030311
更新日期：2017-03-21 00:00:00
abstract：:Patients with irritable bowel syndrome (IBS) exhibit low-grade inflammation and increased gut permeability. Dietary sugar has been shown to contribute to low-grade inflammation and increased gut permeability, and to correlate with gastrointestinal (GI) symptoms. The aim of the present study was to examine the effect o...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11071662
更新日期：2019-07-20 00:00:00
abstract：:Patients suffering from Crohn's disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimul...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010216
更新日期：2021-01-13 00:00:00
abstract：:A target-based approach has been used to develop novel drugs in many therapeutic fields. In the final stage of intracellular signaling, transcription factor-DNA interactions are central to most biological processes and therefore represent a large and important class of targets for human therapeutics. Thus, we focused ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7115445
更新日期：2015-10-30 00:00:00
abstract：:Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091981
更新日期：2019-08-22 00:00:00
abstract：:Dear Editor, We read with interest the recently published original article entitled "Beverage Consumption Habits and Association with TotalWater and Energy Intakes in the Spanish Population: Findings of the ANIBES Study" by Nissensohn et al. [1] in Nutrients.[...]. ...
journal_title：Nutrients
pub_type： 信件
doi：10.3390/nu8080453
更新日期：2016-07-27 00:00:00
abstract：:The aim was to investigate the influence of a carbohydrate (CHO) mouth rinse on the vastus lateralis (VL) and rectus femoris (RF) electromyographic activity (EMG) and time to exhaustion (TE) during moderate (MIE) and high-intensity cycling exercise (HIE). Thirteen participants cycled at 80% of their respiratory compen...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8030049
更新日期：2016-03-09 00:00:00
abstract：:Cancer is the main cause of mortality and morbidity worldwide. Although a large variety of therapeutic approaches have been developed and translated into clinical protocols, the toxic side effects of cancer treatments negatively impact patients, allowing cancer to grow. Brassica metabolites are emerging as new weapons...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030868
更新日期：2020-03-24 00:00:00
abstract：:Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020454
更新日期：2019-02-22 00:00:00
abstract：:Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. T...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10020248
更新日期：2018-02-22 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of pathological hepatic conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which may predispose to liver cirrhosis and hepatocellular carcinoma (HCC). Due to the epidemic obesity, NAFLD is representing a global health i...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11112642
更新日期：2019-11-04 00:00:00
abstract：:Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in met...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9040323
更新日期：2017-03-24 00:00:00
abstract：:Rheumatoid arthritis (RA) is a debilitating, chronic, inflammatory, autoimmune disease associated with cachexia. The substitutive therapy of gut hormone ghrelin has been pointed at as a potential countermeasure for the management of metabolic and inflammatory complications in RA. The recent discovery of liver-expresse...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu12041006
更新日期：2020-04-06 00:00:00
abstract：:Gynostemma pentaphyllum is widely used in Asia as a herbal medicine to treat type 2 diabetes, dyslipidemia, and inflammation. Here, we investigated the anti-obesity effect and underlying mechanism of G. pentaphyllum extract (GPE) enriched in gypenoside L, gypenoside LI, and ginsenoside Rg3 and obtained using a novel e...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102475
更新日期：2019-10-15 00:00:00
abstract：:The imbalance of gut microbiota is known to be associated with inflammatory bowel disease, but it remains unknown whether dysbiosis is a cause or consequence of chronic gut inflammation. In order to investigate the effects of gut inflammation on microbiota and metabolome, the sequential changes in gut microbiota and m...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu9121329
更新日期：2017-12-06 00:00:00
abstract：:Many celiac disease patients tolerate oats, but limited data are available on its long-term consumption. This was evaluated in the present study, focusing on small-bowel mucosal histology and gastrointestinal symptoms in celiac adults maintaining a strict gluten-free diet with or without oats. Altogether 106 long-term...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5114380
更新日期：2013-11-06 00:00:00
abstract：:Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030595
更新日期：2019-03-12 00:00:00
abstract：:Given the complexity of oxygen-induced retinopathy (OIR), we tested the hypothesis that combination therapies and modes of administration would synergistically optimize efficacy for prevention of OIR. Newborn rats were exposed to neonatal intermittent hypoxia (IH) from the first day of life (P0) until P14 during which...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12071980
更新日期：2020-07-03 00:00:00
abstract：:Ingestion of pure fructose stimulates de novo lipogenesis and gluconeogenesis. This may however not be relevant to typical nutritional situations, where fructose is invariably ingested with glucose. We therefore assessed the metabolic fate of fructose incorporated in a mixed meal without or with glucose in eight healt...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu6072632
更新日期：2014-07-15 00:00:00
abstract：:Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency durin...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9020159
更新日期：2017-02-20 00:00:00
abstract：:Restricting animal-based products from diet may exert beneficial effects on weight status; however, less is known about such a diet and emotional health. Moreover, personality traits, for example high neuroticism, may contribute to restrictive eating habits and potentially confound diet-health associations. We aim to ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051492
更新日期：2020-05-20 00:00:00
