Abstract：
:Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Cañete A,Cano E,Muñoz-Chápuli R,Carmona Rdoi
10.3390/nu9020159subject
Has Abstractpub_date
2017-02-20 00:00:00issue
2issn
2072-6643pii
nu9020159journal_volume
9pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract：:Oxylipins are metabolized from dietary ω3 and ω6 polyunsaturated fatty acids and are involved in an inflammatory response. Adipose tissue inflammatory background is a key factor of metabolic disorders and it is accepted that dietary fatty acids, in terms of quality and quantity, modulate oxylipin synthesis in this tis...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020438
更新日期：2019-02-20 00:00:00
abstract：:Endotoxin-induced acute liver injury is mediated by an excessive inflammatory response, hepatocellular oxidative stress, and apoptosis. Traditional medicinal plants have been used to treat various disorders. Platycodon grandifloras (PG) has been shown to be beneficial in relieving cough and asthma and to have anti-tum...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092802
更新日期：2020-09-13 00:00:00
abstract：:A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to ...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11040708
更新日期：2019-03-27 00:00:00
abstract：:Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101430
更新日期：2018-10-04 00:00:00
abstract：:Both type 2 prediabetes/diabetes (T2DM) and new-onset prediabetes/diabetes after acute pancreatitis (NODAP) are characterized by impaired tissue sensitivity to insulin action. Although the outcomes of NODAP and T2DM are different, it is unknown whether drivers of insulin resistance are different in the two types of di...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092883
更新日期：2020-09-21 00:00:00
abstract：:No previous reviews or meta-analyses have specifically assessed the effects of increased fruit and vegetable (FV) intake on weight loss with a primary focus on women. Several studies show differences between men and women in how increased FV intake affects their weight loss and maintenance, risk of becoming overweight...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12071919
更新日期：2020-06-29 00:00:00
abstract：BACKGROUND:this study examined the effects of caffeine supplementation on anaerobic performance, neuromuscular efficiency and upper and lower extremities fatigue in Olympic-level boxers. METHODS:Eight male athletes, members of the Spanish National Olympic Team, were enrolled in the study. In a randomized double-blind,...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11092120
更新日期：2019-09-05 00:00:00
abstract：:Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whos...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061706
更新日期：2020-06-07 00:00:00
abstract：INTRODUCTION:The influence of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation on health outcomes has been studied extensively with randomized controlled trials (RCT). In many research fields, difficulties with recruitment, adherence and high drop-out rates have been reported. However, what is un...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9050474
更新日期：2017-05-10 00:00:00
abstract：:People living in non-Mediterranean West Balkan countries have diets with a low n-3 polyunsaturated fatty acid (PUFA) content. Walnuts, a traditional Serbian food, could be an excellent source of n-3 PUFA. The first sub-study evaluated the fatty acid and mineral content of Serbian walnuts, demonstrating that walnuts ha...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu12010192
更新日期：2020-01-10 00:00:00
abstract：BACKGROUND:Choice of food is an imperative aspect of quality of life for residents in Residential Aged Care Homes (RACHs), where overall choice and control is diminished upon entering a home to receive care. The purpose of this study was to examine the current strategies of menu planning in a range of RACHs in Australi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7095354
更新日期：2015-09-09 00:00:00
abstract：:Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune syste...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12103039
更新日期：2020-10-03 00:00:00
abstract：:Trimethylamine-N-oxide (TMAO) is a small organic molecule, derived from the intestinal and hepatic metabolism of dietary choline and carnitine. Although the involvement of TMAO in the framework of many chronic diseases has been recently described, no evidence on its putative role in the central nervous system has been...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9101053
更新日期：2017-09-22 00:00:00
abstract：:Mobile applications may improve dietary reporting among young adults due to their high accessibility and embedded camera function. This pilot study aimed to (i) evaluate users' acceptability and compliance in reporting dietary intake using a newly developed food diary mobile application (food app); and (ii) identify i...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010062
更新日期：2017-01-13 00:00:00
abstract：:This study aimed to compare calculated nutrient intakes from two different food composition databases using data from the European prospective investigation into cancer and nutrition (EPIC) cohort. Dietary intake data of the EPIC cohort was recently matched to 150 food components from the U.S. nutrient database (USNDB...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102906
更新日期：2020-09-23 00:00:00
abstract：:Evidence from numerous observational and clinical studies suggest that polyphenolic phytochemicals such as phenolic acids in olive oil, flavonols in tea, chocolate and grapes, and isoflavones in soy products reduce the risk of breast cancer. A dietary food pattern naturally rich in polyphenols is the Mediterranean die...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8090547
更新日期：2016-09-06 00:00:00
abstract：:A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 38...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11030561
更新日期：2019-03-06 00:00:00
abstract：:Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used t...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113245
更新日期：2020-10-23 00:00:00
abstract：:Increased prevalence of metabolic syndrome (MetS) has become a global major public health problem. Chronic low-grade inflammation associated with diet was found to play an import role in the development of MetS, although further studies are needed. The main purpose of this study was to explore the association between ...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu10070831
更新日期：2018-06-27 00:00:00
abstract：:Keratoconjunctivitis sicca (KCS) or dry eye is a disease characterized by ocular surface symptoms. This study aimed to investigate the effectiveness of oral choline alfoscerate (CA) administration as a treatment for KCS. The medical records of dry eye patients who were refractory to topical eyedrops and then took oral...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051526
更新日期：2020-05-23 00:00:00
abstract：:Poor food literacy behaviours may contribute to food insecurity in developed countries. The aim of this research was to describe the apparent prevalence of food insecurity in adults at enrolment in a food literacy program and to examine the relationship between food insecurity and a range of independent variables. Ind...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020445
更新日期：2019-02-20 00:00:00
abstract：:Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on ex...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11123067
更新日期：2019-12-16 00:00:00
abstract：:Increasing fish consumption is recommended for intake of omega-3 (n-3) fatty acids and to confer benefits for the risk reduction of cardiovascular disease (CVD). Most Americans are not achieving intake levels that comply with current recommendations. It is the goal of this review to provide an overview of the issues a...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu5041081
更新日期：2013-03-28 00:00:00
abstract：:The composition and functioning of the gut microbiota, the complex population of microorganisms residing in the intestine, is strongly affected by endogenous and exogenous factors, among which diet is key. Important perturbations of the microbiota have been observed to contribute to disease risk, as in the case of neu...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12113319
更新日期：2020-10-29 00:00:00
abstract：:In this report, we present a detailed comparison of the lipid composition of human milk (HM) and formula milk (FM) targeting different lactation stages and infant age range. We studied HM samples collected from 26 Polish mothers from colostrum to 19 months of lactation, along with FM from seven brands available on the...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072165
更新日期：2020-07-21 00:00:00
abstract：:Cancer is the main cause of mortality and morbidity worldwide. Although a large variety of therapeutic approaches have been developed and translated into clinical protocols, the toxic side effects of cancer treatments negatively impact patients, allowing cancer to grow. Brassica metabolites are emerging as new weapons...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030868
更新日期：2020-03-24 00:00:00
abstract：:Cherries are known for their nutraceutical properties, in particular for their antioxidant ability due to their polyphenol content, which causes a reduction of cardiovascular disease (CVD) risk factors. However, once ingested these molecules are degraded in the Gastrointestinal (GI) tract before reaching the blood, wh...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111598
更新日期：2018-11-01 00:00:00
abstract：:Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010059
更新日期：2020-12-27 00:00:00
abstract：:The chemopreventive and anticancer effects of resveratrol (RSV) are widely reported in the literature. Specifically, mechanisms involving epigenetic regulation are promising targets to regulate tumor development. Bromodomains act as epigenetic readers by recognizing lysine acetylation on histone tails and boosting gen...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9111172
更新日期：2017-10-27 00:00:00
abstract：:People seeking asylum in high-income countries are vulnerable to food insecurity due to limited opportunities for social and economic participation. While charity organizations have long sought to provide food aid to those in need, the increasing number of people seeking this assistance requires alternatives. Using a ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10060756
更新日期：2018-06-12 00:00:00
