Abstract:
:Gastroesophageal reflux disease (GERD) affects approximately 20% of Australians. Patients suffer a burning sensation known as heartburn due to the movement of acidic stomach content into the esophagus. There is anecdotal evidence of the effectiveness of prebiotic sugarcane flour in controlling symptoms of GERD. This pilot study aimed to investigate the effectiveness of a prebiotic sugarcane flour in alleviating symptoms in medically-diagnosed GERD patients. This pilot study was a single center, double-blinded, placebo-controlled randomized trial conducted on 43 eligible participants. The intervention group (n = 22) were randomized to receive 3 g of sugarcane flour per day, and the control group (n = 21) received 3 g of cellulose placebo per day. Symptoms of gastroesophageal reflux disease were assessed before and after three weeks treatment using the validated Gastroesophageal Reflux Disease-Health Related Quality of Life questionnaire (GERD-HRQL). After three weeks there were significant differences in symptoms for heartburn, regurgitation, and total symptoms scores (p < 0.05) between the sugarcane flour and placebo. Mean GERD-HRQL scores increased in the placebo group for regurgitation (mean increase 1.7; 95% CI 0.23 to 3.2; p = 0.015) and total symptom scores (2.9; 95% CI 0.26 to 5.7; p = 0.033). In contrast, there were significant reductions in heartburn (mean decrease -2.2; 95% CI -4.2 to -0.14; p = 0.037) and total symptom scores (-3.7; 95% CI -7.2 to -0.11; p = 0.044) in the intervention group. This pilot study has shown significant positive effects of sugarcane flour in the reduction of GERD symptoms, and a larger randomized controlled trial is warranted.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Beckett JM,Singh NK,Phillips J,Kalpurath K,Taylor K,Stanley RA,Eri RDdoi
10.3390/nu12061813subject
Has Abstractpub_date
2020-06-18 00:00:00issue
6issn
2072-6643pii
nu12061813journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract::Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in met...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9040323
更新日期:2017-03-24 00:00:00
abstract::The objective of the study was to investigate the potential association of human milk leptin concentrations with child body mass index (BMI) and BMI trajectory patterns up to two years of age among children in the Ulm SPATZ Health Study. Leptin concentration was measured in skimmed human milk by ELISA (R&D System). Ch...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081883
更新日期:2019-08-13 00:00:00
abstract::Discrepancies exist among food processing classification systems and in the relationship between processed food intake and dietary quality of children. This study compared inter-rater reliability, food processing category, and the relationship between processing category and nutrient concentration among three systems ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061344
更新日期:2019-06-14 00:00:00
abstract::Childhood obesity is a global problem with many contributing factors including dietary energy density (DED). This paper aims to investigate potential predictors of DED among preschool aged children in Victoria, Australia. Secondary analysis of longitudinal data for 209 mother-child pairs from the Melbourne Infant Feed...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10020178
更新日期:2018-02-06 00:00:00
abstract::Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu2050532
更新日期:2010-05-01 00:00:00
abstract::Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm infants. Formula feeding is a risk factor for NEC and osmolality, which is increased by the fortification that is required for adequate growth of the infant, has been suggested as a potential cause. Our laboratory has sho...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040900
更新日期:2020-03-26 00:00:00
abstract::Sedentary habits during childhood are associated with adverse health outcomes. The aim of this work was to cluster lifestyle behaviors and metabolic biomarkers to establish different patterns in children. Their physical and sedentary activities were evaluated by accelerometry, and questionnaires that included lifestyl...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051288
更新日期:2020-05-01 00:00:00
abstract::Vitamin D deficiency is a common issue, particularly in obese populations, and is tested by assessing serum 25(OH)D concentrations. This study aimed to identify factors that contribute to the vitamin D status in fifty morbidly obese individuals recruited prior to bariatric surgery. Data collected included serum 25(OH)...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101094
更新日期:2017-10-04 00:00:00
abstract::Patients with irritable bowel syndrome (IBS) exhibit low-grade inflammation and increased gut permeability. Dietary sugar has been shown to contribute to low-grade inflammation and increased gut permeability, and to correlate with gastrointestinal (GI) symptoms. The aim of the present study was to examine the effect o...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11071662
更新日期:2019-07-20 00:00:00
abstract::The major part of iron present in plant foods such as cereals is largely unavailable for direct absorption in humans due to complexation with the negatively charged phosphate groups of phytate (myo-inositol (1,2,3,4,5,6)-hexakisphosphate). Human biology has not evolved an efficient mechanism to naturally release iron ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu5083074
更新日期:2013-08-02 00:00:00
abstract::Chile has implemented several strategies to decrease the burden of obesity and chronic diseases. The Food Labeling and Advertising Law (Law 20.606) requires a front-of-package "high in" warning label when energy and nutrients of concern (ENC) (total sugar, saturated fats, sodium) exceed established limits. This study ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082371
更新日期:2020-08-08 00:00:00
abstract:BACKGROUND:Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxici...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9060625
更新日期:2017-06-17 00:00:00
abstract::The present study evaluated the reliability of equations using spot urine (SU) samples in the estimation of 24-hour urine sodium excretion (24-HUNa). Equations estimating 24-HUNa from SU samples were derived from first-morning SU of 101 participants (52.4 ± 11.1 years, range 24-70 years). Equations developed by us and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6062360
更新日期:2014-06-20 00:00:00
abstract::Mechanistic data have revealed a key role for selenium (Se) and selenoproteins in biological pathways known to be altered in multifactorial diseases, such as cellular maintenance, response to oxidative stress and correct protein folding. Although epidemiological studies indicate that low Se intake is linked to increas...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7053621
更新日期:2015-05-15 00:00:00
abstract::Accumulating evidence clarifies that intestinal barrier function, for example, by the mucus layer, antimicrobial peptides, immune systems, and epithelial tight junctions, plays crucial roles in maintaining our health. We reported previously that yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 an...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122998
更新日期:2019-12-07 00:00:00
abstract::Dietary restraint is a commonly reported practice observed among young females. The practice remains controversial and can be interpreted as a beneficial self-regulating behavior or the opposite, an eating disorder that may have a detrimental effect on health. The aim of this short report was to investigate if dietary...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8120796
更新日期:2016-12-19 00:00:00
abstract::Plants belonging to the genus Opuntia spp. are the most abundant of the Cactaceae family, grown throughout America and the Mediterranean central area. Its fruit, known as cactus pear or prickly pear, is an oval berry grouped in different colors. Some studies have shown its antioxidant activities which may help in prev...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5104145
更新日期:2013-10-18 00:00:00
abstract::Gluten cross-contamination in gluten-free food may jeopardize treatment of celiac patients. Considering the deficit of appropriate instruments to enable the implementation of safe production practices for gluten-free food, this study aimed to evaluate the application of a check-list elaborated for gluten cross-contami...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091274
更新日期:2018-09-10 00:00:00
abstract::The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise can attenuate the loss of muscle mass during severe energy deficit (5500 kcal/day). Overweight men...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11112824
更新日期:2019-11-19 00:00:00
abstract:BACKGROUND:The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease. METHODS:We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challeng...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112551
更新日期:2019-10-23 00:00:00
abstract::Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7125497
更新日期:2015-11-27 00:00:00
abstract:BACKGROUND:The prevalence of anorexia nervosa among males is increasing but few data are available in the literature. This cross sectional study aims to evaluate resting energy expenditure (REE) and phase angle as a marker of qualitative changes of fat free mass (FFM) in three leanness groups as compared with control s...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030502
更新日期:2019-02-27 00:00:00
abstract::Infancy and childhood are periods of physical and cognitive development that are vulnerable to disruption by dehydration; however, the effects of dehydration on cognitive development during the periods have not yet been fully elucidated. Thus, the present study used a murine model to examine the effects of sustained d...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12030670
更新日期:2020-02-29 00:00:00
abstract::Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were larg...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030495
更新日期:2019-02-27 00:00:00
abstract::Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa keeps rising regardless of the emerging cutting-edge technologies for treatment and drug designation. There are a number of treatment options which are effective...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030679
更新日期:2020-03-02 00:00:00
abstract::Glycyrrhetinic acid (GA), a bioactive component in the human diet, has been reported to improve hyperglycemia, dyslipidemia, insulin resistance and obesity in rats with metabolic syndrome. However, GA-specific target proteins and the mechanisms involved in the downstream signaling and cross-talk to improve insulin sen...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030604
更新日期:2019-03-12 00:00:00
abstract::Socio-economic status (SES) has an impact on food consumption in developing countries. However, the impact of SES on dietary patterns in Filipino school-aged children is currently unknown. The aim of this study was to fill this knowledge gap, using data from the 2013 National Nutrition Survey. Dietary intake of 11,691...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122910
更新日期:2019-12-02 00:00:00
abstract::Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030518
更新日期:2019-02-28 00:00:00
abstract::This cross-sectional study investigated the association between eating alone at each meal and health status, including functional capacity among community-dwelling Japanese elderly living with others. A self-administered questionnaire was mailed to all 8004 residents aged 65 or older, residing in the same Japanese tow...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092805
更新日期:2020-09-13 00:00:00
abstract::Vegetarian diets have gained popularity in sports. However, few data exist on the status of micronutrients and related biomarkers for vegetarian and vegan athletes. The aim of this cross-sectional study was to compare the micronutrient status of omnivorous (OMN, n = 27), lacto-ovo-vegetarian (LOV, n = 26), and vegan (...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051146
更新日期:2019-05-22 00:00:00