Abstract:
:Glial activation and neuroinflammation play significant roles in apoptosis as well as in the development of cognitive and memory deficits. Neuroinflammation is also a critical feature in the pathogenesis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. Previously, hesperetin has been shown to be an effective antioxidant and anti-inflammatory agent. In the present study, in vivo and in vitro analyses were performed to evaluate the neuroprotective effects of hesperetin in lipopolysaccharide (LPS)-induced neuroinflammation, oxidative stress, neuronal apoptosis and memory impairments. Based on our findings, LPS treatment resulted in microglial activation and astrocytosis and elevated the expression of inflammatory mediators such as phosphorylated-Nuclear factor-κB (p-NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in the cortical and hippocampal regions and in BV2 cells. However, hesperetin cotreatment markedly reduced the expression of inflammatory cytokines by ameliorating Toll-like receptor-4 (TLR4)-mediated ionized calcium-binding adapter molecule 1/glial fibrillary acidic protein (Iba-1/GFAP) expression. Similarly, hesperetin attenuated LPS-induced generation of reactive oxygen species/lipid per oxidation (ROS/LPO) and improved the antioxidant protein level such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Haem-oxygenase (HO-1) in the mouse brain. Additionally, hesperetin ameliorated cytotoxicity and ROS/LPO induced by LPS in HT-22 cells. Moreover, hesperetin rescued LPS-induced neuronal apoptosis by reducing the expression of phosphorylated-c-Jun N-terminal kinases (p-JNK), B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and Caspase-3 protein and promoting the Bcl-2 protein level. Furthermore, hesperetin enhanced synaptic integrity, cognition, and memory processes by enhancing the phosphorylated-cAMP response element binding protein (p-CREB), postsynaptic density protein-95 (PSD-95), and Syntaxin. Overall, our preclinical study suggests that hesperetin conferred neuroprotection by regulating the TLR4/NF-κB signaling pathway against the detrimental effects of LPS.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Muhammad T,Ikram M,Ullah R,Rehman SU,Kim MOdoi
10.3390/nu11030648subject
Has Abstractpub_date
2019-03-17 00:00:00issue
3issn
2072-6643pii
nu11030648journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract::The adenylate cyclase 3 (ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10060789
更新日期:2018-06-19 00:00:00
abstract::Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and pos...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061777
更新日期:2020-06-15 00:00:00
abstract::Selenium, an essential trace element known mainly for its antioxidant properties, is critical for proper brain function and regulation of energy metabolism. Whole-body knockout of the selenium recycling enzyme, selenocysteine lyase (Scly), increases susceptibility to metabolic syndrome and diet-induced obesity in mice...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071693
更新日期:2019-07-23 00:00:00
abstract::Normal-weight obesity (NWO) has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in early adulthood. The aim of this study was to investigate the associations between NWO and cardiometabolic risk factors in a large population of Colombian youn...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041106
更新日期:2020-04-16 00:00:00
abstract::Alu hypomethylation promotes genomic instability and is associated with aging and age-related diseases. Dietary factors affect global DNA methylation, leading to changes in genomic stability and gene expression with an impact on longevity and the risk of disease. This preliminary study aims to investigate the relation...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122986
更新日期:2019-12-06 00:00:00
abstract::Melanoidins are the final Maillard reaction products (protein-carbohydrate complexes) produced in food by prolonged and intense heating. We assessed the impact of the consumption of melanoidins from barley malts on gut microbiota. Seventy-five mice were assigned into five groups, where the control group consumed a non...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010241
更新日期:2020-01-17 00:00:00
abstract::The home food environment (HFE) is an important factor in the development of food preferences and habits in young children, and the availability of foods within the home reflects dietary intake in both adults and children. Therefore, it is important to consider the holistic quality of the HFE. The purpose of this stud...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020372
更新日期:2019-02-12 00:00:00
abstract::The COVID-19 pandemic is having major economic and personal consequences for collegiate and professional sports. Sporting events have been canceled or postponed, and even when baseball and basketball seasons resumed in the United States recently, no fans were in attendance. As play resumed, several players developed C...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123741
更新日期:2020-12-04 00:00:00
abstract::A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerabili...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu9060629
更新日期:2017-06-19 00:00:00
abstract::Drug resistance is a major problem in the treatment of non-small-cell lung cancer (NSCLC). In this study, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to identify the differentially expressed genes in Adriamycin (ADR)-resistant NSCLC A549/ADR cells compared with parental A549 cells. Am...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121829
更新日期:2018-11-26 00:00:00
abstract::Chicken extract, which is rich in anserine and carnosine, has been widely taken in Asian countries as a traditional remedy with various aims, including attenuation of psychological fatigue. The effects of consuming BRAND'S Essence of Chicken (EOC) or a placebo on 46 young adults' responses to a standard psychological ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7020887
更新日期:2015-01-29 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with "moderate" hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. SUBJECTS/METHODS:We performed ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5051531
更新日期:2013-05-08 00:00:00
abstract::We aimed to assess the association between oral health, in terms of its impact on quality of life, and diet quality expressed as adherence to dietary guidelines. We analyzed cross-sectional data from the French NutriNet-Santé general population-based e-cohort (N = 18,263 adults; mean age = 56.5 ± 13.8 ye...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10050527
更新日期:2018-04-24 00:00:00
abstract::Dietary intake of vitamin A (VA) and carotenes has shown beneficial effects for decreasing the risk of some types of cancer, but findings on the risk of primary liver cancer (PLC) are inconsistent. This case-control study explored the associations between the dietary intake of VA and carotenes and the risk of PLC. We ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100624
更新日期:2016-10-11 00:00:00
abstract::Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish intake on the subsequent risk of a hip fracture because of the low number of studies on this topic. A...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10070873
更新日期:2018-07-06 00:00:00
abstract::Insufficient dietary intake, micronutrient deficiencies, and infection may result in malnutrition. In Zambia, an estimated 14% of women are vitamin A-deficient, ~50% are anemic, 10% are underweight, and 23% are overweight/obese. A cross-sectional survey determined food and nutrient intakes of randomly selected Zambian...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020288
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Chronic kidney disease and inflammation promote loss of Klotho expression. Given the well-established anti-inflammatory effects of omega-3 fatty acids, we aimed to investigate the effect of fish oil supplementation in a model of CKD. METHODS:Male C57BL/6 mice received supplementation with an adenine-enriche...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091283
更新日期:2018-09-11 00:00:00
abstract::In this study, we investigated the beneficial effects of milk biofortified with antioxidants on the health of children. Two experiments were conducted: experiment one evaluated the milk of 24 Jersey dairy cows (450 ± 25 kg of body weight (BW); 60 ± 30 days in milk dry matter intake (DIM)) given different diet treatmen...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11061218
更新日期:2019-05-29 00:00:00
abstract::Despite the life stage of menopause being identified as a high risk for weight gain, there are few obesity prevention interventions for this target group, and no evidence on maintenance of intervention effects after intervention support is withdrawn. In the 40-Something Randomized Controlled Trial (RCT) (ACTRN12611000...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu11051100
更新日期:2019-05-17 00:00:00
abstract::Most human selenium containing proteins contain selenium in the form of the amino acid selenocysteine, which is encoded in the corresponding mRNA as a UGA codon. Only a few non-selenocysteine containing selenoproteins are present and the nature of the association with selenium is not well understood. This review focus...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7053938
更新日期:2015-05-22 00:00:00
abstract::Disturbed eating behaviours have been widely reported in psychotic disorders since the early 19th century. There is also evidence that antipsychotic (AP) treatment may induce binge eating or other related compulsive eating behaviours. It is therefore possible that abnormal eating patterns may contribute to the signifi...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123883
更新日期:2020-12-18 00:00:00
abstract::Micronutrient deficiencies remain a serious nutritional concern in Bangladesh, especially among rural women of reproductive age (WRA). This study assesses the diet quality of reproductive-aged adolescent girls and adult women (referred to together as WRA in this study), including socio-demographic factors associated w...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13020337
更新日期:2021-01-23 00:00:00
abstract::Increases in the number of food outlets have been proposed as a key factor driving obesity. This study aimed to investigate the association between the densities of food establishments serving meals (excluding supermarkets and grocery stores), with body mass index (BMI), waist to hip ratio (WHR) and percentage of body...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040890
更新日期:2020-03-25 00:00:00
abstract::Obesity and type 2 diabetes have both rapidly increased during the last decades and are continuing to increase at an alarming rate worldwide. Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies document...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11071506
更新日期:2019-07-01 00:00:00
abstract::Influenza virus type A (IAV) is a seasonal acute respiratory disease virus with severe symptoms, and an effective preventive measure is required. Despite many reports describing the potentially protective effects of lactic acid bacteria, few studies have investigated the effects of nutritional supplement combinations....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12102925
更新日期:2020-09-24 00:00:00
abstract::Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11092228
更新日期:2019-09-16 00:00:00
abstract::It has been reported that maternal nutrition determines the offspring's susceptibility to chronic diseases including cancer. Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring. Dams were fed a casein (CAS) diet...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12020571
更新日期:2020-02-22 00:00:00
abstract::l-carnitine (LC) is a co-factor in fatty acid metabolism; its role with respect to aortic stiffness (AS) associated with chronic kidney disease (CKD) was unclear. Our aim was to investigate associations between serum LC levels and AS in patients with non-dialysis CKD stage 3-5. The AS patients were those with carotid-...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12102918
更新日期:2020-09-24 00:00:00
abstract::Human milk (HM) influences infant feeding patterns and body composition (BC). This small proof-of concept longitudinal study investigated relationships between infant/maternal BC and HM casein, whey and total protein during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured at 2 (n = 15)...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091332
更新日期:2018-09-19 00:00:00
abstract::Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal defic...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6093818
更新日期:2014-09-19 00:00:00