Does vitamin C deficiency affect cognitive development and function?

Abstract:

:Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

journal_name

Nutrients

journal_title

Nutrients

authors

Hansen SN,Tveden-Nyborg P,Lykkesfeldt J

doi

10.3390/nu6093818

subject

Has Abstract

pub_date

2014-09-19 00:00:00

pages

3818-46

issue

9

issn

2072-6643

pii

nu6093818

journal_volume

6

pub_type

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