Abstract:
:Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Hansen SN,Tveden-Nyborg P,Lykkesfeldt Jdoi
10.3390/nu6093818subject
Has Abstractpub_date
2014-09-19 00:00:00pages
3818-46issue
9issn
2072-6643pii
nu6093818journal_volume
6pub_type
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