Abstract:
BACKGROUND:Patients with esophageal cancer (EC) have high rates of malnutrition due to tumor location and treatment-related toxicity. Various strategies are used to improve nutritional status in patients with EC including oral and enteral support. METHODS:We conducted a retrospective analysis to determine the impact of malnutrition and prophylactic feeding jejunostomy tube (FJT) placement on toxicity and outcomes in patients with localized EC who were treated with neoadjuvant chemoradiation therapy (nCRT) followed by esophagectomy. RESULTS:We identified 125 patients who were treated with nCRT between 2002 and 2014. Weight loss and hypoalbuminemia occurred frequently during nCRT and were associated with multiple adverse toxicity outcomes including hematologic toxicity, nonhematologic toxicity, grade ≥3 toxicity, and hospitalizations. After adjusting for relevant covariates including the specific nCRT chemotherapy regimen received and the onset of toxicity, there were no significant associations between hypoalbuminemia, weight loss, or FJT placement and relapse-free survival (RFS) or overall survival (OS). FJT placement was associated with less weight loss during nCRT (p = 0.003) but was not associated with reduced toxicity or improved survival. CONCLUSIONS:Weight and albumin loss during nCRT for EC are important factors relating to treatment toxicity but not RFS or OS. While pretreatment FJT placement may reduce weight loss, it may not impact treatment tolerance or survival.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Jain R,Shaikh T,Yee JL,Au C,Denlinger CS,Handorf E,Meyer JE,Dotan Edoi
10.3390/nu12103177subject
Has Abstractpub_date
2020-10-17 00:00:00issue
10issn
2072-6643pii
nu12103177journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract::Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12010054
更新日期:2019-12-24 00:00:00
abstract::Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. The aim of this study was to explore how these proteins enter saliva and their r...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123838
更新日期:2020-12-16 00:00:00
abstract::Optimising the diet and weight of women prior to and during pregnancy is of paramount importance to both maternal and offspring health. In women who become pregnant after bariatric surgery, evidence suggests a better overall obstetric outcome in comparison to women with severe obesity managed conservatively. Historica...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11092116
更新日期:2019-09-05 00:00:00
abstract::Large portions of high energy dense (HED) snacks are offered to children from a young age and are pervasive in our food environment. This study aimed to explore the feasibility, acceptability, and preliminary efficacy of two strategies of snack portion control: reduction and replacement. Forty-six mother-child dyads a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101493
更新日期:2018-10-12 00:00:00
abstract::Dietary habits in adolescence persist into adulthood; thus, it is important to identify the factors that influence adolescent diet and establish a healthy diet. This study aimed to examine the association between mothers' nutrition knowledge and their children's nutrient intake inadequacy among Japanese junior high sc...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092801
更新日期:2020-09-13 00:00:00
abstract::A cross-sectional survey of 2819 adults aged 20 years and above was undertaken in 2002 in Jiangsu Province. Zinc intake was assessed using a consecutive 3-day 24-h dietary recall method. Insufficient and excess intake was determined according to the Chinese Dietary Recommended Intakes. Four distinct dietary patterns w...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu4060517
更新日期:2012-06-01 00:00:00
abstract::Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes. Previous research from our group indicates that a high-fat and rapid-digesting carbohydrate diet during pregnancy promotes a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12020528
更新日期:2020-02-19 00:00:00
abstract::The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 438...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122885
更新日期:2019-11-27 00:00:00
abstract::This study investigated effects of patchouli essential oil (PEO) inhalation on metabolic parameters. First, to characterize aromatic compounds in PEO, solid-phase microextraction-gas chromatography/mass spectrometric detection was employed in which 19 aromatic compounds were identified. In GC-olfactometry analysis, li...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072077
更新日期:2020-07-13 00:00:00
abstract::Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80%...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091984
更新日期:2019-08-22 00:00:00
abstract::Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of the survival motor neuron protein (SMN) re...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123842
更新日期:2020-12-16 00:00:00
abstract::The aim of the study was to assess the amount of orally administered carbohydrates needed to maintain euglycemia during moderate-intensity exercise in individuals with type 1 diabetes. Nine participants with type 1 diabetes (four women, age 32.1 ± 9.0 years, BMI 25.5 ± 3.9 kg/m2, HbA1c 55 ± 7 mmol/mol (7.2 ± 0.6%)) on...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11061287
更新日期:2019-06-06 00:00:00
abstract::The marketing of unhealthy commodities through traditional media is known to impact consumers' product attitudes and behaviors. Less is known about the impacts of digital marketing (online promotional activities), especially among young people who have a strong online presence. This review systematically assesses the ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10020148
更新日期:2018-01-29 00:00:00
abstract::Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092862
更新日期:2020-09-18 00:00:00
abstract::The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112676
更新日期:2019-11-05 00:00:00
abstract:BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071555
更新日期:2019-07-10 00:00:00
abstract::Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal defic...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6093818
更新日期:2014-09-19 00:00:00
abstract::There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD). However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear. This study examined whether the effects of isomaltodextrin on gut mi...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072088
更新日期:2020-07-15 00:00:00
abstract::Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus (CRV) possess a high phenolic compound content with excellent antioxidant activity. Dietary antioxidants can reduce exercise-induced oxidative stress. Consumption of large amounts of phenolic compounds is positively correlated with reduction in exercise-indu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081715
更新日期:2019-07-25 00:00:00
abstract::Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081871
更新日期:2019-08-12 00:00:00
abstract::Breastfeeding is a gold standard of feeding of newborns and infants. Tandem breastfeeding (TBF) is feeding two children of different ages at the same time. The knowledge about the composition of human milk in prolonged lactation is still scarce. Milk from tandem breastfeeding women and after weaning was examined. Milk...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010277
更新日期:2021-01-19 00:00:00
abstract::Parents' stress is independently associated with increased child adiposity, but parents' stress may also interfere with childhood obesity prevention programs. The disruptions to the family dynamic caused by participating in a behaviour change intervention may exacerbate parent stress and undermine overall intervention...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061835
更新日期:2020-06-19 00:00:00
abstract::In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11051093
更新日期:2019-05-16 00:00:00
abstract::Many infant formulas are fortified with iron at 8-14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron conten...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010003
更新日期:2020-12-22 00:00:00
abstract::The COVID-19 pandemic has disrupted many aspects of daily life. The purpose of this study was to identify how health behaviors, level of stress, financial and food security have been impacted by the pandemic among Canadian families with young children. Parents (mothers, n = 235 and fathers, n = 126) from 254 families ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082352
更新日期:2020-08-07 00:00:00
abstract::Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm infants. Formula feeding is a risk factor for NEC and osmolality, which is increased by the fortification that is required for adequate growth of the infant, has been suggested as a potential cause. Our laboratory has sho...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040900
更新日期:2020-03-26 00:00:00
abstract::The major part of iron present in plant foods such as cereals is largely unavailable for direct absorption in humans due to complexation with the negatively charged phosphate groups of phytate (myo-inositol (1,2,3,4,5,6)-hexakisphosphate). Human biology has not evolved an efficient mechanism to naturally release iron ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu5083074
更新日期:2013-08-02 00:00:00
abstract::The ketogenic diet has long been recommended in patients with neurological disorders, and its protective effects on the cardiovascular system are of growing research interest. This study aimed to investigate the effects of two-week of low-calorie ketogenic nutrition drinks in obese adults. Subjects were randomized to ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10121895
更新日期:2018-12-03 00:00:00
abstract::Plants belonging to the genus Opuntia spp. are the most abundant of the Cactaceae family, grown throughout America and the Mediterranean central area. Its fruit, known as cactus pear or prickly pear, is an oval berry grouped in different colors. Some studies have shown its antioxidant activities which may help in prev...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5104145
更新日期:2013-10-18 00:00:00
abstract::The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111785
更新日期:2018-11-16 00:00:00